As a process for producing seamless tubes, the tandem skew rolling (TSR) process was proposed. In order to study deformation characteristics and mechanism on tubes obtained by the TSR process, a numerical simulation of the process was analyzed using Deform-3D software. Simulation results demonstrated the distribution of stress, strain, velocity, and temperature of a seamless tube in the stable stage during the TSR process. Actual experiments of carbon steel 1045, high strength steel 42CrMo, and magnesium alloy AZ31 were carried out in a TSR testing mill. The results demonstrated that the TSR process is qualified for producing tubes of high quality, with an accuracy of ±0.2 mm in wall thickness and ±0.35 mm in diameter. This process is suitable for manufacturing seamless tubes that are difficult to deform or that have been deformed in a narrow range of temperature.