Thermo/pH dual-stimuli-responsive drug delivery for chemo-/photothermal therapy monitored by cell imaging

Shu, Yang; Song, Rusheng; Zheng, Anqi; Huang, Jing‐Li; Chen, Mingli; Wang, Jianhua

doi:10.1016/j.talanta.2018.01.018

Cited by 56 publications

(22 citation statements)

References 35 publications

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“…In addition, breast cancer therapy that relies on a single chemotherapy agent fails to achieve satisfactory therapeutic efficacy. Therefore, current progress in chemotherapy has gradually turned to combinational therapy, which can integrate the advantages of other treatments, such as photothermal therapy (PTT), gene therapy, and immunotherapy, for a favorable therapeutic outcome …”

Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water‐responsive phospholipid‐calcium‐carbonate hybrid nanoparticle (PL/ACC‐DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near‐infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer. PL/ACC‐DOX&ICG exhibits satisfactory stability against various aqueous environments with minimal drug leakage and can readily decompose to facilitate quick drug release into cancer cells. In vivo biodistribution studies, PL/ACC‐DOX&ICG demonstrated strong tumor‐homing properties. Interestingly, the in vitro cellular uptake and intratumoral penetration depth of PL/ACC‐DOX&ICG are significantly enhanced under NIR laser irradiation, owing to ICG‐induced hyperthermia, which not only enhances cell permeability and fluidity but also disrupts the dense tumor extracellular matrix. Compared to chemotherapy or photothermal therapy alone, chemophotothermal combination therapy synergistically induces apoptosis and death in 4T1 cells. Moreover, compared with the phosphate buffer saline group, the combined treatment suppress primary tumor growth at a rate of approximately 94.88% and decrease the number of metastatic nodules by about 93.6%. Therefore, PL/ACC‐DOX&ICG may be a promising nanoplatform for breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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“…The polymer remains fully solvated below the LCST, but higher temperatures result in the polymer rapidly collapsing into a hypercoiled state. As the LCST is within the standard physiological temperature conditions, copolymers are often included with PNIPAM to increase its LCST to the range of 40-45 • C [142][143][144]. MSNs using grafted PNIPAM copolymers demonstrated phototheragnostic potential with fluorescence and photoacoustic functionality.…”

Section: External Stimulimentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

et al. 2021

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Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were extensively investigated as a novel approach to improve clinical outcomes. Boasting an impressive array of formulations and modifications, MSNs demonstrate significant in vivo efficacy when used to identify or treat myriad malignant diseases in preclinical models. As MSNs continue transitioning into clinical trials, a thorough understanding of the characteristics of effective MSNs is necessary. This review highlights recent discoveries and advances in MSN understanding and technology. Specific focus is given to cancer theragnostic approaches using MSNs. Characteristics of MSNs such as size, shape, and surface properties are discussed in relation to effective nanomedicine practice and projected clinical efficacy. Additionally, tumor-targeting options used with MSNs are presented with extensive discussion on active-targeting molecules. Methods for decreasing MSN toxicity, improving site-specific delivery, and controlling release of loaded molecules are further explained. Challenges facing the field and translation to clinical environments are presented alongside potential avenues for continuing investigations.

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“…In recent years, MSNs have emerged as powerful candidates for DDSs and they have been widely used for the codelivery of PA and chemotherapy drugs as a combination therapy (Shu et al, 2018 ; Tian et al, 2018 ). Copper sulfide nanoparticles (CuS NPs) (Chen F. et al, 2015 ; Zhang et al, 2015a , b ; Zhang Y. et al, 2015 ; Peng et al, 2017 ; Wang F. et al, 2018 ; Li et al, 2020 ), polydopamine (PDA) (Zhang et al, 2018 ; Chen C. et al, 2019 ), gold nanorods (AuNR) (Zhang et al, 2012 ; Liu et al, 2015 ; Huang et al, 2017 ; Ramasamy et al, 2018 ; Sun X. et al, 2018 ; Wang Y. et al, 2019 ), gold shells (Rahman et al, 2017 ), reduced graphene oxide (rGO) (Liu et al, 2019 ), GO (Tang et al, 2015 ; Tran et al, 2018 ) and carbon dots (CDs) (Singh et al, 2016 ; Zhang et al, 2020b ) are common PAs introduced in the PTT-chemotherapy systems.…”

Section: Chemotherapy and Phototherapymentioning

confidence: 99%

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

Gao

Shen

et al. 2020

Front. Chem.

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Chemotherapy is an important anti-tumor treatment in clinic to date, however, the effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic toxicity, and multidrug resistance. In recent years, mesoporous silica nanoparticles (MSNs) have become exciting drug delivery systems (DDS) due to their unique advantages, such as easy large-scale production, adjustable uniform pore size, large surface area and pore volumes. While mesoporous silica-based DDS can improve chemotherapy to a certain extent, when used in combination with other cancer therapies MSN based chemotherapy exhibits a synergistic effect, greatly improving therapeutic outcomes. In this review, we discuss the applications of MSN DDS for a diverse range of chemotherapeutic combination anti-tumor therapies, including phototherapy, gene therapy, immunotherapy and other less common modalities. Furthermore, we focus on the characteristics of each nanomaterial and the synergistic advantages of the combination therapies. Lastly, we examine the challenges and future prospects of MSN based chemotherapeutic combination therapies.

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Thermo/pH dual-stimuli-responsive drug delivery for chemo-/photothermal therapy monitored by cell imaging

Cited by 56 publications

References 35 publications

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

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