Thermo-responsive behaviors and bioactivities of hydroxybutyl chitosans prepared in alkali/urea aqueous solutions

Cai, Yan; Cao, Jinfeng; Xu, Chi; Zhou, Jinping

doi:10.1016/j.carbpol.2019.03.044

Cited by 27 publications

(33 citation statements)

References 51 publications

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“…The substitution reaction was also confirmed by 1 H NMR. As shown in Figure 2 , new peaks were observed in HBCOS at 0.8–1.5 ppm with the ratio of the integrated area being 3:2, which were not present in COS. Those peaks were attributed to the methyl and methylene of the hydroxybutyl groups ( Cai et al, 2019 ). These results indicated that hydroxybutyl groups was introduced to the COS chains.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, the DS of HBCOSs showed a negative correlation with the cloud point. This can be explained by the enhancement of the hydrophobic interactions among the hydroxybutyl groups with increases in DS ( Cai et al, 2019 ). The increase in the transmission intensity upon cooling indicated that the thermoresponsive behaviors of all HBCOS samples were reversible, which were not affected by the DS.…”

Section: Resultsmentioning

confidence: 99%

“…1 H NMR spectra of HBCOSs and COS were recorded on a Bruker AVANCE III 600 MHz (Bruker, Germany) at 25°C to measure the DS. The DS of HBCOSs was calculated using the following equation ( Cai et al, 2019 ):

…”

Section: Methodsmentioning

confidence: 99%

“…However, a complicated preparation, including purification with acid and freeze (below −10°C)–thawing process (under high alkaline/urea conditions), is required to dissolve these polysaccharides in NaOH prior to carrying out further alkylation modifications ( Qi et al, 2012 ; Bi et al, 2017 ). Furthermore, the high alkalinity of the reaction system results in the degradation of the polysaccharide chains ( Sun et al, 2017 ; Cai et al, 2019 ). Thus, the poor solubility of natural macromolecules in alkaline condition limits their alkylation modification.…”

Section: Introductionmentioning

confidence: 99%

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Tunable Thermo-Responsive Properties of Hydroxybutyl Chitosan Oligosaccharide

Chen

Zhang

et al. 2022

Front. Chem.

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In this study, a simple method was used to synthesize novel thermosensitive hydroxybutyl chitosan oligosaccharide (HBCOS) by introducing hydroxybutyl groups to C6–OH of chitosan oligosaccharide (COS) chain. The variation in light scattering demonstrated that HBCOS had good thermosensitive properties and the particle size of HBCOS changed from 2.21–3.58 to 281.23–4,162.40 nm as the temperature increased to a critical temperature (LCST). The LCST of HBCOS (10 mg/ml) decreased from 56.25°C to 40.2°C as the degrees of substitution (DSs) increased from 2.96 to 4.66. The LCST of HBCOS with a DS of 4.66 decreased to 33.5°C and 30°C as the HBCOS and NaCl concentrations increased to 50 mg/ml and 4% (w/v), respectively. Variable-temperature FTIR spectroscopy confirmed that dehydration of hydrophobic chains and the transition of hydrogen bonds were the driving forces for the phase transition of HBCOS. Moreover, HBCOS was not cytotoxic at different concentrations. This work generated a novel thermosensitive HBCOS with tunable thermoresponsive properties and excellent biocompatibility, which may be a potential nanocarrier for the biomedical application.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tunable Thermo-Responsive Properties of Hydroxybutyl Chitosan Oligosaccharide

Chen

Zhang

et al. 2022

Front. Chem.

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“…Carboxymethyl chitosan, another water‐soluble chitosan derivative, was successfully synthesized by the reaction between ‐OH or ‐NH 2 of chitosan and monochloroacetic acid under alkaline condition 12 . Moreover, hydroxybutyl chitosan was obtained by grafting of hydroxybutyl groups to the ‐OH at C 6 position and ‐NH 2 at C 2 position in the chitosan molecule to improve its hydrophobicity, leading to thermoresponsive behaviors 13 . These provide advantages of optimal hydrophilicity for chitosan and show promise in drug delivery applications.…”

Section: Preparation Of Chitosan Nanoparticlesmentioning

confidence: 99%

Chitosan‐based self‐assembled nanomaterials: Their application in drug delivery

Liu

Sun

Wang

et al. 2020

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Nanoparticles have long been one of the most popular delivery systems for enhancing the stability of therapeutic agents, providing targeted drug transportation, sustaining drug concentration at sites of action, and promoting therapeutic efficacy. Chitosan‐based nanoparticles have been widely explored as drug delivery systems due to the unique biological properties, such as easy to chemical modifications, biocompatibility, mucoadhesive feature, and absorption enhancement. In this review, we outline the biological properties and stimuli‐sensitive strategies of chitosan‐based self‐assembled nanoparticles as well as the recent developments in various applications in drug delivery, including cancer treatment, oral administration, skin regeneration, nasal/ocular mucosal administration, and pulmonary drug delivery. Chitosan‐based nanoparticles exhibit excellent features as drug delivery systems due to the outstanding biological properties. As the suitable vehicles for drug administration, chitosan‐based nanoparticles facilitate and improve drug bioavailability in all cases.

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Recent developments of polysaccharide‐based double‐network hydrogels

Zhang

Shi

Zhou

2022

Journal of Polymer Science

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Polysaccharides possessing distinctive properties, such as biocompatibility, biodegradability, and nontoxicity, are promising matrices for hydrogels. However, the polysaccharides‐based hydrogels have poor mechanical properties, which is a major limitation for their applications. In recent years, researches on double‐network (DN) hydrogels with outstanding mechanical properties have gained increasing attention. Therefore, the main research orientation is to combine the benefits of both materials and broaden their applications in various fields. This paper reviews the recent progress of polysaccharide‐based DN (PDN) hydrogels that show great advantages in mechanical, physiochemical properties, biocompatibility, biodegradability and so on. The preparation, structure, and unique properties of different PDN hydrogels are discussed in detail. Moreover, we summarize the applications of PDN hydrogels in biomedical and energy storage and conversion fields. This research progress is breaking through the limitations of PDN hydrogels and opening a new avenue for their future development.

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Thermo-responsive behaviors and bioactivities of hydroxybutyl chitosans prepared in alkali/urea aqueous solutions

Cited by 27 publications

References 51 publications

Tunable Thermo-Responsive Properties of Hydroxybutyl Chitosan Oligosaccharide

Tunable Thermo-Responsive Properties of Hydroxybutyl Chitosan Oligosaccharide

Chitosan‐based self‐assembled nanomaterials: Their application in drug delivery

Recent developments of polysaccharide‐based double‐network hydrogels

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