Thermo-responsive hydrogels for cancer local therapy: Challenges and state-of-art

Rafael, Diana; Melendres, Maria Mercè Roca; Andrade, Fernanda; Montero, Sara; Martinez-Trucharte, Francesc; Vilar-Hernández, Mireia; Durán-Lara, Esteban F.; Abasolo, Ibane

doi:10.1016/j.ijpharm.2021.120954

Cited by 52 publications

(30 citation statements)

References 82 publications

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“…Hydrogels can be used to help give localized controlled release of cancer drugs to desired locations without the adverse off-target effects. Thermo-responsive drug delivery hydrogel systems have been seen to work well as they change states at different temperatures to help with the loading and release of cancer drugs [95]. An example of the thermo-responsive hydrogel was chitosan/Disulfiram (DSF)-loaded hydrogel which released the anticancer drug DSF.…”

Section: Cancer Therapymentioning

confidence: 99%

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Mahmood

Patel

Hickson

et al. 2022

IJMS

126

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Hydrogels from biopolymers are readily synthesized, can possess various characteristics for different applications, and have been widely used in biomedicine to help with patient treatments and outcomes. Polysaccharides, polypeptides, and nucleic acids can be produced into hydrogels, each for unique purposes depending on their qualities. Examples of polypeptide hydrogels include collagen, gelatin, and elastin, and polysaccharide hydrogels include alginate, cellulose, and glycosaminoglycan. Many different theories have been formulated to research hydrogels, which include Flory-Rehner theory, Rubber Elasticity Theory, and the calculation of porosity and pore size. All these theories take into consideration enthalpy, entropy, and other thermodynamic variables so that the structure and pore sizes of hydrogels can be formulated. Hydrogels can be fabricated in a straightforward process using a homogeneous mixture of different chemicals, depending on the intended purpose of the gel. Different types of hydrogels exist which include pH-sensitive gels, thermogels, electro-sensitive gels, and light-sensitive gels and each has its unique biomedical applications including structural capabilities, regenerative repair, or drug delivery. Major biopolymer-based hydrogels used for cell delivery include encapsulated skeletal muscle cells, osteochondral muscle cells, and stem cells being delivered to desired locations for tissue regeneration. Some examples of hydrogels used for drug and biomolecule delivery include insulin encapsulated hydrogels and hydrogels that encompass cancer drugs for desired controlled release. This review summarizes these newly developed biopolymer-based hydrogel materials that have been mainly made since 2015 and have shown to work and present more avenues for advanced medical applications.

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Section: Cancer Therapymentioning

confidence: 99%

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Mahmood

Patel

Hickson

et al. 2022

IJMS

126

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Section: Routes Of Drugs Administrationmentioning

confidence: 99%

“…These systems ensure a controlled and sustained drug release, significantly decreasing their frequency of administration. Besides, NLH systems can maintain the therapeutic levels of drugs, thus increasing their efficacy [39]. Peng et al (2013) proposed poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHB-HHx) NPs incorporated in a thermosensitive hydrogel for an ultralong sustained release of insulin for diabetes management [40].…”

Section: Routes Of Drugs Administrationmentioning

confidence: 99%

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

et al. 2022

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Clinically available medications face several hurdles that limit their therapeutic activity, including restricted access to the target tissues due to biological barriers, low bioavailability, and poor pharmacokinetic properties. Drug delivery systems (DDS), such as nanoparticles (NPs) and hydrogels, have been widely employed to address these issues. Furthermore, the DDS improves drugs’ therapeutic efficacy while reducing undesired side effects caused by the unspecific distribution over the different tissues. The integration of NPs into hydrogels has emerged to improve their performance when compared with each DDS individually. The combination of both DDS enhances the ability to deliver drugs in a localized and targeted manner, paired with a controlled and sustained drug release, resulting in increased drug therapeutic effectiveness. With the incorporation of the NPs into hydrogels, it is possible to apply the DDS locally and then provide a sustained release of the NPs in the site of action, allowing the drug uptake in the required location. Additionally, most of the materials used to produce the hydrogels and NPs present low toxicity. This article provides a systematic review of the polymeric NPs-loaded hydrogels developed for various biomedical applications, focusing on studies that present in vivo data.

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“…Several drug-delivery systems, such as drug depots [230][231][232], hydrogels [233][234][235][236], microspheres [237,238], or nanocarriers (NCs) [239,240], have been developed and investigated. For intra-tumoral drug delivery and for bypassing physiological barriers, local drug-loaded depots and hydrogels have allowed the long-term delivery of treatment at the site of action [234,241].…”

Section: Simulated Metronomic Therapies: Nanocarriers For Cancer Therapymentioning

confidence: 99%

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment

Muñoz

Girotti

Hileeto

et al. 2021

Cancers

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The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary tumors and metastases. These factors determine cellular co-evolution in time and space, contribute to tumor progression, and could counteract therapeutic effects. Additionally, cancer therapies can induce cellular and molecular responses in the tumor and host that allow them to escape therapy and promote tumor progression. In this study, we describe the vascular network, tumor-infiltrated immune cells, and cancer-associated fibroblasts as sources of heterogeneity and plasticity in the tumor microenvironment, and their influence on cancer progression. We also discuss tumor and host responses to the chemotherapy regimen, at the maximum tolerated dose, mainly targeting cancer cells, and a multimodal metronomic chemotherapy approach targeting both cancer cells and their microenvironment. In a combination therapy context, metronomic chemotherapy exhibits antimetastatic efficacy with low toxicity but is not exempt from resistance mechanisms. As such, a better understanding of the interactions between the components of the tumor microenvironment could improve the selection of drug combinations and schedules, as well as the use of nano-therapeutic agents against certain malignancies.

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Thermo-responsive hydrogels for cancer local therapy: Challenges and state-of-art

Cited by 52 publications

References 82 publications

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment

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