Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers

Hsu, Shan‐hui; Chen, Christopher; Hung, Kun Che; Tsai, Yi Chun; Li, Suming

doi:10.3390/polym8070252

Cited by 23 publications

(15 citation statements)

References 25 publications

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“…This shape/volume-changing property is useful for building actuators in soft robot and drug delivery systems. For example, thermo-responsive hydrogels, when combined with polymers, act as good drug delivery systems [59,60,61,62]. For example, a thermo-sensitive hydrogel, poly( N -isopropylacrylamide) (pNIPAM), was used to design a clamping mechanism in an inchworm-like robot by creating a difference in frictional force as a result of the hydrophilic (soft) and hydrophobic (tough) nature when heated below/above the LCST [63].…”

Section: Hydrogel-based Soft Actuatorsmentioning

confidence: 99%

Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges

2018

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There are numerous developments taking place in the field of biorobotics, and one such recent breakthrough is the implementation of soft robots-a pathway to mimic nature's organic parts for research purposes and in minimally invasive surgeries as a result of their shape-morphing and adaptable features. Hydrogels (biocompatible, biodegradable materials that are used in designing soft robots and sensor integration), have come into demand because of their beneficial properties, such as high water content, flexibility, and multi-faceted advantages particularly in targeted drug delivery, surgery and biorobotics. We illustrate in this review article the different types of biomedical sensors and actuators for which a hydrogel acts as an active primary material, and we elucidate their limitations and the future scope of this material in the nexus of similar biomedical avenues.

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Section: Hydrogel-based Soft Actuatorsmentioning

confidence: 99%

Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges

2018

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“…PU hydrogels are attractive materials that find multiple applications in the biomedical sector, [ 43,44 ] like for tissue engineering, [ 45,46 ] drug delivery, [ 47–50 ] antibiofouling, [ 51,52 ] or for robust and smart hydrophilic materials. [ 53,54 ] Although there are many reports on PU hydrogels, examples of analogue material made of PHU are rare.…”

Section: Introductionmentioning

confidence: 99%

Water‐Borne Isocyanate‐Free Polyurethane Hydrogels with Adaptable Functionality and Behavior

Bourguignon

Thomassin

Grignard

et al. 2020

Macromol. Rapid Commun.

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Polyurethane hydrogels are attractive materials finding multiple applications in various sectors of prime importance; however, they are still prepared by the toxic isocyanate chemistry. Herein the facile and direct preparation in water at room temperature of a large palette of anionic, cationic, or neutral polyurethane hydrogels by a non‐isocyanate route from readily available diamines and new hydrosoluble polymers bearing cyclic carbonates is reported. The latter are synthesized by free radical polymerization of glycerin carbonated methacrylate with water‐soluble comonomers. The hydrogel formation is studied at different pH and its influence on the gel time and storage modulus is investigated. Reinforced hydrogels are also constructed by adding CaCl2 to the formulation that in‐situ generates CaCO3 particles. Thermoresponsive hydrogels are also prepared from new thermoresponsive cyclic carbonate bearing polymers. This work demonstrates that a multitude of non‐isocyanate polyurethane hydrogels are easily accessible under mild conditions without any catalyst, opening new perspectives in the field.

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“…Segmented polyurethane (SPU) is widely used in biomedical fields, such as cardiovascular devices, artificial organs, and tissue engineering scaffolds, due to its long-term bio-stability, excellent mechanical properties, and relatively superior biocompatibility [1,2,3,4,5,6]. However, when SPU is used as long-term blood-contacting materials, the surface of SPU films will result in significant adsorption of proteins, and induce platelet adhesion by activating the coagulation pathway, eventually leading to the formation of microscopic thrombi [7,8].…”

Section: Introductionmentioning

confidence: 99%

A Mild Method for Surface-Grafting PEG Onto Segmented Poly(Ester-Urethane) Film with High Grafting Density for Biomedical Purpose

et al. 2018

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In the paper, poly(ethylene glycol) (PEG) was grafted on the surface of poly(ester-urethane) (SPEU) film with high grafting density for biomedical purposes. The PEG-surface-grafted SPEU (SPEU-PEG) was prepared by a three-step chemical treatment under mild-reaction conditions. Firstly, the SPEU film surface was treated with 1,6-hexanediisocyanate to introduce -NCO groups on the surface with high density (5.28 × 10−7 mol/cm2) by allophanate reaction; subsequently, the -NCO groups attached to SPEU surface were coupled with one of -NH2 groups of tris(2-aminoethyl)amine via condensation reaction to immobilize -NH2 on the surface; finally, PEG with different molecular weight was grafted on the SPEU surface through Michael addition between terminal C = C bond of monoallyloxy PEG and -NH2 group on the film surface. The chemical structure and modified surface were characterized by FT-IR, 1H NMR, X-ray photoelectron spectroscopy (XPS), and water contact angle. The SPEU-PEGs displaying much lower water contact angles (23.9–21.8°) than SPEU (80.5°) indicated that the hydrophilic PEG chains improved the surface hydrophilicity significantly. The SPEU-PEG films possessed outstanding mechanical properties with strain at break of 866–884% and ultimate stress of 35.5–36.4 MPa, which were slightly lower than those of parent film, verifying that the chemical treatments had minimum deterioration on the mechanical properties of the substrate. The bovine serum albumin adsorption and platelet adhesion tests revealed that SPEU-PEGs had improved resistance to protein adsorption (3.02–2.78 μg/cm2) and possessed good resistance to platelet adhesion (781–697 per mm2), indicating good surface hemocompatibility. In addition, due to the high grafting density, the molecular weight of surface-grafted PEG had marginal effect on the surface hydrophilicity and hemocompatibility.

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Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers

Cited by 23 publications

References 25 publications

Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges

Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges

Water‐Borne Isocyanate‐Free Polyurethane Hydrogels with Adaptable Functionality and Behavior

A Mild Method for Surface-Grafting PEG Onto Segmented Poly(Ester-Urethane) Film with High Grafting Density for Biomedical Purpose

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