Thermo-responsiveness and biocompatibility of star-shaped poly[2-(dimethylamino)ethyl methacrylate]-b-poly(sulfobetaine methacrylate) grafted on a β-cyclodextrin core

Zhang, Mingming; Shen, Wei; Xiong, Qingqing; Wang, Hongwei; Zhou, Zhimin; Chen, Wenjuan; Zhang, Qiqing

doi:10.1039/c5ra02115d

Cited by 32 publications

(24 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering these techniques, star‐shaped macromolecules can be synthesized via core‐first method using naturally occurring cores. This approach uses a multi‐functional molecule to initiate polymerization, where the number of arms can be determined from the functionality of the initiator resulting in well‐defined structures …”

Section: Introductionmentioning

confidence: 99%

Tannic Acid‐Inspired Star‐Like Macromolecules via Temporally Controlled Multi‐Step Potential Electrolysis

Zaborniak

Chmielarz

Wolski

et al. 2019

Macro Chemistry & Physics

View full text Add to dashboard Cite

Inspired by tea stains, a plant polyphenolic‐based macroinitiator is prepared for the first time by partial modification of tannic acid (TA) with 2‐bromoisobutyryl bromide. In accordance with the “grafting from” methodology, a naturally occurring star‐like polymer with a polar gallotannin core and a hydrophobic poly(n‐butyl acrylate) side arms is synthesized via a simplified electrochemically mediated ATRP (seATRP), utilizing multiple‐step potential electrolysis. To investigate the kinetics of the electrochemical catalytic process triggered by reduction of Cu(II) or Fe(III) catalytic complex in the presence of the multifunctional initiator, cyclic voltammetry measurements are conducted. The naturally derived tannin macromolecule shows narrow MWDs (Đ = 1.57). Moreover, solvolysis of the star polymer to cleave the side arms and characterize them indicates that all chains grow to the same length (homopolymers with Mw/Mn <1.17), which confirms the well‐controlled seATRP. The structure of the obtained TA‐based systems is characterized microscopically (AFM) and spectroscopically (1H NMR, FT‐IR). Atomic force microscopy measurements precisely determine the diameters of the obtained star polymers (19.7 ± 3.3 nm). These new star polymers may find biomedical applications as drug delivery systems and antifouling or antimicrobial coatings.

show abstract

Section: Introductionmentioning

confidence: 99%

Tannic Acid‐Inspired Star‐Like Macromolecules via Temporally Controlled Multi‐Step Potential Electrolysis

Zaborniak

Chmielarz

Wolski

et al. 2019

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…This method has been applied to hydrophobic (meth) acrylates [14,15,[19][20][21][22][23][24][25][26], and hydrophilic (meth)acrylates and (meth)acrylamides [14, 16-18, 25, 27-31] for the synthesis of well-defined polymeric architec-tures. Star-shaped cationic polymers, consisting of multiple arms linked to a central β-cyclodextrin (β-CD) core, have recently attracted much attention, because of their dense branched architecture with moderate flexibility, tunable properties like solubility, chemically crosslinked structure, temperature or pH sensitivity, which could be manipulated by the parameters such as the block composition, MW, and arm number [32][33][34][35][36][37][38][39][40][41][42][43][44]. Amphiphilic star copolymers composed of poly(2-dimethylaminoethyl methacrylate)-block-poly(n-butyl acrylate) (PDMAEMA-b-PBA) arms covalently linked to a β-CD core are especially interesting, because they can be used in biomedical applications, including drug delivery and tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of cationic star polymers by simplified electrochemically mediated ATRP

Chmielarz¹

2016

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract. Cyclodextrin-based cationic star polymers were synthesized using β-cyclodextrin (β-CD) core, and 2-(dimethylamino)ethyl methacrylate (DMAEMA) as hydrophilic arms. Star-shaped polymers were prepared via a simplified electrochemically mediated ATRP (seATRP) under potentiostatic and galvanostatic conditions. The polymerization results showed molecular weight (MW) evolution close to theoretical values, and maintained narrow molecular weight distribution (MWD) of obtained stars. The rate of the polymerizations was controlled by applying more positive potential values thereby suppressing star-star coupling reactions. Successful chain extension of the ω-functional arms with a hydrophobic n-butyl acrylate (BA) formed star block copolymers and confirmed the living nature of the β-CD-PDMAEMA star polymers prepared by seATRP. Novelty of this work is that the β-CD-PDMAEMA-b-PBA cationic star block copolymers were synthesized for the first time via seATRP procedure, utilizing only 40 ppm of catalyst complex. The results from 1 H NMR spectral studies support the formation of cationic star (co)polymers.

show abstract

“…This phenomenon is also illustrated by Zhang et al on a star-shaped copolymer consisting of a zwitterionic as well as a cationic block grafted on a hydrophobic cyclodextrine core [ 321 ]. Due to the UCST behavior of the zwitterionic polymer, an increase in temperature causes the zwitterionic block to collapse around the cationic segment, which results in the formation of an outer corona of sticky patches.…”

Section: Reviewmentioning

confidence: 71%

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Flemming¹,

Münch²,

Fery³

et al. 2021

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

In the last decades, numerous stimuli-responsive polymers have been developed and investigated regarding their switching properties. In particular, thermoresponsive polymers, which form a miscibility gap with the ambient solvent with a lower or upper critical demixing point depending on the temperature, have been intensively studied in solution. For the application of such polymers in novel sensors, drug delivery systems or as multifunctional coatings, they typically have to be transferred into specific arrangements, such as micelles, polymer films or grafted nanoparticles. However, it turns out that the thermodynamic concept for the phase transition of free polymer chains fails, when thermoresponsive polymers are assembled into such sterically confined architectures. Whereas many published studies focus on synthetic aspects as well as individual applications of thermoresponsive polymers, the underlying structure–property relationships governing the thermoresponse of sterically constrained assemblies, are still poorly understood. Furthermore, the clear majority of publications deals with polymers that exhibit a lower critical solution temperature (LCST) behavior, with PNIPAAM as their main representative. In contrast, for polymer arrangements with an upper critical solution temperature (UCST), there is only limited knowledge about preparation, application and precise physical understanding of the phase transition. This review article provides an overview about the current knowledge of thermoresponsive polymers with limited mobility focusing on UCST behavior and the possibilities for influencing their thermoresponsive switching characteristics. It comprises star polymers, micelles as well as polymer chains grafted to flat substrates and particulate inorganic surfaces. The elaboration of the physicochemical interplay between the architecture of the polymer assembly and the resulting thermoresponsive switching behavior will be in the foreground of this consideration.

show abstract

Thermo-responsiveness and biocompatibility of star-shaped poly[2-(dimethylamino)ethyl methacrylate]-b-poly(sulfobetaine methacrylate) grafted on a β-cyclodextrin core

Abstract: CDPDS star polymers exhibit tunable UCST behavior by varying arm density, solution pH and NaCl concentration, and can be good candidates used in biomedical relevant fields as well.

Cited by 32 publications

References 46 publications

Tannic Acid‐Inspired Star‐Like Macromolecules via Temporally Controlled Multi‐Step Potential Electrolysis

Tannic Acid‐Inspired Star‐Like Macromolecules via Temporally Controlled Multi‐Step Potential Electrolysis

Synthesis of cationic star polymers by simplified electrochemically mediated ATRP

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Contact Info

Product

Resources

About