Thermo-reversible self-assembled novel gellan gum hydrogels containing amino acid biogelators with antibacterial activity

Exploring gellan gum-based hydrogels for regenerating human embryonic stem cells in age-related macular degeneration therapy: A literature review

“…Materials such as silk fibroin, chitin, and pectin do not exhibit thermo-reversible behaviour. [ 34 , 42 ] Tunability Easily tunable through adjustments in concentration, crosslinking density, and composition. Enables precise control over hydrogel properties.…”

“…For instance, Silk Fibroin necessitates electrospinning, while chitosan may require precipitation for gel formation and Poly (lactic-co-glycolic acid) fabrication involves emulsion and solvent casting techniques. [ [40] , [41] , [42] , [43] , [44] ] Biocompatibility Natural origin minimizes the risk of cytotoxicity and immunogenicity In general, natural biomaterials tend to be more compatible than synthetic counterparts; however, biomaterials such as sodium alginate may necessitate surface modification for enhanced compatibility. [ 34 , 45 ] Biodegradability Biodegradable, gradually replaced by new tissue and supports tissue regeneration.…”

“… It varies; for instance, some materials like Polyethylene Glycol (PEG) may necessitate enzymatic degradation. [ [40] , [41] , [42] , [43] , [44] , [45] ] Biofunctionalization Can be functionalized with bioactive molecules. Tailors hydrogel for specific cellular responses Direct biofunctionalization of synthetic polymers like Poly (lactic-co-glycolic acid) compared to naturally derived polymers like gellan gum, silk fibroin, and chitosan may present challenges [ 34 , 46 ] Sterilizability Compatible with various sterilization methods.…”

“…Synthetic polymers like Polyethylene Glycol exhibit variability in stability. [ [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] ] …”

Innovative Use of an Injectable, Self-Healing Drug-Loaded Pectin-Based Hydrogel for Micro- and Supermicro-Vascular Anastomoses

“…The creep test caused a time-dependent increase in strain, comprising elastic and viscous contributions. For illustrative purposes, the creep phase in Figure S15 is divided into three main zones, each exhibiting distinct components: (a) instantaneous elastic deformation, (b) delayed elastic deformation, and (c) viscous (Newtonian) flow elements of strain 15,16 . The elastic behavior of the sample can be attributed to the stretching of linkages between structural units.…”