Thermo-sensitive hydrogel on anodized titanium surface to regulate immune response

Li, Baoe; Zhang, Lei; Wang, Donghui; Liu, Xuanyong; Li, Haipeng; Liang, Chunyong; Zhao, Xiangen

doi:10.1016/j.surfcoat.2020.126624

Cited by 13 publications

(7 citation statements)

References 38 publications

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“…The drug-loaded TRHs can be also used as coating materials in bone tissue engineering for reducing the bacteria-associated infection. Recently, a TRH composed of hydroxypropyl methylcellulose (HMPC), chitosan (CS), and glycerin (Gly) was synthesized and denoted as CGHH [ 68 ]. Optical microscope photographs of the hydrogel in Figure 5 A shows that CGHH was a smooth film without any cracks at 37 °C.…”

Section: Temperature-responsive Hydrogels (Trhs)mentioning

confidence: 99%

“… ( A ) Optical microscopic images of the hydrogel at 37 °C (sol state) and 40 °C (gel state); ( B(i) ) schematic illustration of the CGHH@NT sample; ( B(ii) ) SEM image of the NT sample; ( B(iii) ) SEM image of the CGHH@NT sample; ( C(i) ) HPMC release profile; ( C(ii) ) CS release profile; ( C(iii) ) Gly release profile; and ( D ) schematic illustration of the thermo-sensitive immunoregulation of the CGHH@NT sample. Reprinted with permission from [ 68 ]. …”

Section: Figurementioning

confidence: 99%

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Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

167

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Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

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Section: Temperature-responsive Hydrogels (Trhs)mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

167

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“…The use of TiO 2 NT on Ti implants is a superb surface engineering technique and drug therapies can be enabled by using such technologies, which are capable of achieving excellent results [ 66 , 67 ]. The glycerin (Gly)-loaded thermo-sensitive chitosan (CS)/hydroxypropyl methylcellulose (HPMC) on the anodized Ti surface has been used as coating material, called CS-Gly-HPMC hydrogel (CGHH@NT), for reducing the bacteria-associated infection after implantation ( Figure 3 ) [ 68 ]. The finding of the study demonstrated the ability of Gly to inhibit the inflammatory response, induce macrophages to polarize towards an anti-inflammatory M2 phenotype, and generate anti-inflammatory cytokines, which enhance tissue regeneration.…”

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

“… ( a ( i )) schematic illustration of the CGHH@NT sample; ( a ( ii )) SEM image of the NT sample; ( a ( iii )) SEM image of the CGHH@NT sample, ( b ) schematic illustration of the thermo-sensitive immunoregulation of the CGHH@NT sample: (1) bacterial infection; (2) macrophages recruitment; (3) local temperature increase; (4) phase transformation of CGHH@NT from sol state to gel state, leading to the release of Gly, (5) macrophages were polarizing toward M1 phenotype, and played their roles in bacteria killing, (6) local temperature decrease resulting in the phase of CGHH@NT reverse transforming to a sol state and releasing HPMC and CS, (7) macrophages were induced to a M2 phenotype, (8) tissue healing were promoted. Reprinted with permission from the reference [ 68 ]. …”

Section: Figurementioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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“…György et al [174] evaluated a new thermoresponsive copolymer, poly(N, N-diethyl acrylamide co-glycidyl methacrylate) (P[DEAAm-co-GMA]) and revealed that not only the polymer composites but enzymes nanoparticles also showed a stimuli response against temperature. Alvi et al [175] answered the issue regarding the drawbacks associated with the local anesthetics by utilizing the chitosan and β-glycerophosphate as a sensitive hydrogel with a phase transition at 37 C. Similarly, other studies are performed on various polymer nanocomposites to examine their thermal properties and stimuli responses like titanium carbide TiC reinforced poly(vinyl chloride)/ poly(ε-caprolactone), [176] anodized titanium surface, [177] ethylene glycol (EG)/propylene glycol (PG)/ methacrylates. [178]…”

Section: Temperature Activementioning

confidence: 99%

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

2022

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The latest developments in smart systems for improved human lives with advanced biomedical devices have evolved out of multi‐disciplinary scientific studies, including medicine, biology, material sciences, design, manufacturing, artificial intelligence, microelectronics, and so forth. The growth of such intelligent systems is primarily possible with innovative materials, which demonstrate the response to various external stimuli like temperature, heat, moisture, light, electromagnetic field, and chemical alteration. Such materials have been recently fabricated using different additive manufacturing techniques to devise personalized unique, complex, and novel structures that can adjust to external conditions over time and are specifically attributed to 4D printing. Novel materials that can further improve such systems continued to be explored and employed. This review paper investigates the additive manufacturing of functional polymer nanocomposites, which offer compliant structures with flexible manufacturing processes with high strength, low cost, and long‐term stability. This study aims to deliver a comprehensive and deep understanding of the latest developments in materials, design, manufacturing, fundamental mechanisms involved, and future possibilities in this area of research.

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Thermo-sensitive hydrogel on anodized titanium surface to regulate immune response

Cited by 13 publications

References 38 publications

Smart Hydrogels for Advanced Drug Delivery Systems

Smart Hydrogels for Advanced Drug Delivery Systems

Recent Advancements in Metallic Drug-Eluting Implants

Additive manufacturing of smart polymeric composites: Literature review and future perspectives

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