Thermo thickening behavior of MPEG-b-PCL grafted Poly(acrylic acid): A molecular insight

Investigation of domain structures in monomethoxy poly(ethylene glycol)‐b‐poly(caprolactone) grafted poly(acrylic acid) by NMR diffusion studies

“…The variation of viscosity as a function of temperature carried out by temperature ramp measurements shows that the critical temperature above which thermo-thickening (anomalous rise in viscosity) occurs shifts to lower temperatures as the solution concentration increases. 21 The temperature-dependent viscosity measurements of the PAA-g-(MPEG-b-PCL) samples, during a full H-C cycle, shows an irreversible increase in viscosity at concentrations above the critical association concentration (Fig. 1).…”

“…The polymers differ in the extent of grafting on the PAA backbone with PAA-g-(MPEG-b-PCL)-1.0 and PAA-g-(MPEGb-PCL)-1.5 representing 1.0 mol% and 1.5 mol% grafting respectively. 21 Viscosity measurements of aqueous solutions of the polymers at 298 K as a function of concentration revealed an anomalous increase in viscosity at concentrations above 5 and 9 mg mL −1 for PAA-g-(MPEG-b-PCL)-1.5 and PAA-g-(MPEG-b-PCL)-1.0 respectively (Fig. S1).…”

“…We recently reported unusual thermo‐irreversible gelation on heating an aqueous solution of monomethoxy poly(ethylene glycol)‐ b ‐poly(caprolactone) (MPEG‐ b ‐PCL) grafted poly(acrylic acid) 21 . Heating leads to increased hydrophobic interactions among the side chains, thus forming highly stable physically crosslinked networks resulting in an irreversible sol‐to‐gel transition.…”

Redox-Sensitive Polymer Micelles Based on CD44 and Folic Acid Receptor for Intracellular Drug Delivery and Drug Controlled Release in Cancer Therapy

“…14−16 Stimuliresponsive amphiphilic block copolymer micelles are highly suitable as drug carriers on account of their unique selfassembly properties. 1,17,18 These micelles can be specifically designed to respond to various stimuli such as pH, 19−21 temperature, 22,23 light, 24,25 and redox. 26−28 However, the complex physiological environment limits the efficacy of single stimulus-responsive systems, resulting in poor drug delivery and increased side effects.…”

“…An ideal drug delivery system should be able to release the drug in a sustained manner and at the target site, reduce drug toxicity, and improve drug stability in circulation. − Stimuli-responsive amphiphilic block copolymer micelles are highly suitable as drug carriers on account of their unique self-assembly properties. ,, These micelles can be specifically designed to respond to various stimuli such as pH, − temperature, , light, , and redox. − However, the complex physiological environment limits the efficacy of single stimulus-responsive systems, resulting in poor drug delivery and increased side effects. To obviate these limitations, researchers have developed multiple stimuli-responsive micellar carriers using functional polymers based on the lower pH and higher levels of reactive oxygen species (ROS) in the tumors relative to normal tissues.…”