Thermoanalytical investigation of drug–excipient interaction

Drebushchak, V. A.; Шахтшнейдер, Т. П.; Apenina, Svetlana A.; Медведева, А. С.; Сафронова, Л. П.; Болдырев, В. В.

doi:10.1007/s10973-005-7440-y

Cited by 33 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In turn, investigations of chemical reactions in molecular solids that occur during mechanical action, including the interactions between drug and excipient is of great interest for pharmacy [3,4], because control of these reactions allows to increase stability and bioavailability of drugs. * corresponding author; e-mail: shah@solid.nsc.ru Different methods such as vibration spectroscopic methods, thermal analysis studies, nuclear magnetic resonance spectroscopy and some others are widely used to characterize these interactions [3][4][5][6][7]. To the best of our knowledge, X-ray photoelectron spectroscopy (XPS) has never been used before for characterization of drug-excipient systems.…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

et al. 2011

View full text Add to dashboard Cite

The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms. It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The amorphous SDs of poorly water-soluble APIs can be obtained with a number of techniques, such as mechanical activation (ball milling), cryogenic co-grinding and quench cooling of a melt [5][6][7][8][9] . Cryogenic co-grinding is a promising technique for both size reduction and obtaining amorphous form of APIs 6,10-12 .…”

Section: Introductionmentioning

confidence: 99%

“…For highly permeable and low soluble drugs, the limiting factor for oral absorption is the dissolution rate of drug and formulation. Amorphous state of PRX has been obtained by mechanical activation, cryogenic grinding, electrospinning and quench cooling of a melt 7,11,14 . Recently, Kogermann et al reported that the amorphous state of PRX can be obtained by ball-milling at low temperature but the major limitation is that amorphous PRX is very unstable 15 .…”

Section: Introductionmentioning

confidence: 99%

Towards improved solubility of poorly water-soluble drugs: cryogenic co-grinding of piroxicam with carrier polymers

Penkina

Semjonov

Hakola

et al. 2015

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

Amorphous solid dispersions (SDs) open up exciting opportunities in formulating poorly watersoluble active pharmaceutical ingredients (APIs). In the present study, novel catalytic pretreated softwood cellulose (CPSC) and polyvinylpyrrolidone (PVP) were investigated as carrier polymers for preparing and stabilizing cryogenic co-ground SDs of poorly water-soluble piroxicam (PRX). CPSC was isolated from pine wood (Pinus sylvestris). Raman and Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) were used for characterizing the solid-state changes and drug-polymer interactions. Highresolution scanning electron microscope (SEM) was used to analyze the particle size and surface morphology of starting materials and final cryogenic co-ground SDs. In addition, the molecular aspects of drug-polymer interactions and stabilization mechanisms are presented. The results showed that the carrier polymer influenced both the degree of amorphization of PRX and stabilization against crystallization. The cryogenic co-ground SDs prepared from PVP showed an enhanced dissolution rate of PRX, while the corresponding SDs prepared from CPSC exhibited a clear sustained release behavior. In conclusion, cryogenic co-grinding provides a versatile method for preparing amorphous SDs of poorly water-soluble APIs. The solid-state stability and dissolution behavior of such co-ground SDs are to a great extent dependent on the carrier polymer used.

show abstract

“…Thermal analysis is one of the most frequently used instrumental techniques on pharmaceutical researches to solve technological problems [9][10][11][12]. The thermal analysis methods are widely used for the study of the stability and decomposition of the substances used in medicine [13][14][15][16][17][18][19][20][21][22][23][24][25]. The evaluation of the stability of a drug in solid form is realized especially by analysing its decomposition in isothermal and non-isothermal conditions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and thermal study of new N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones of Mannich base type

Krzyżak

Szczęśniak-Sięga

Szkatuła

et al. 2011

J Therm Anal Calorim

View full text Add to dashboard Cite

The new derivatives of 3,4-pyridinedicarboximide were synthesised. Experimental measurements were carried out using 1 H NMR spectra, IR spectra, elemental analyses and differential scanning calorimetry. The purpose of this study was to study the thermal stability of these four new compounds and to establish a solid-state polymorphism. Measurements were carried out for samples obtained from ethanol and n-hexane and after a long-time storage.

show abstract

Thermoanalytical investigation of drug–excipient interaction

Cited by 33 publications

References 20 publications

Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

Towards improved solubility of poorly water-soluble drugs: cryogenic co-grinding of piroxicam with carrier polymers

Synthesis and thermal study of new N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones of Mannich base type

Contact Info

Product

Resources

About