Thermochemistry of the Acid-Base Interactions in Aqueous Solutions of Isonicotinic and Picolinic Acids

Lytkin, A. I.; Badelin, V. G.; Krutova, O. N.; Tyunina, E. Yu.; Крутов, П. Д.

doi:10.1134/s1070363219110124

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…where α 1 and α 2 are the fractions of particles H 2 L + and L − , respectively, and and are the enthalpies of stepwise dissociation of the acid, determined earlier at our laboratory (2.31 ± 0.25 and 12.52 ± 0.36 kJ/mol, respectively [18]).…”

Section: Resultsmentioning

confidence: 99%

Standard Enthalpies of Formation of Isonicotinic Acid and Products of Its Dissociation in an Aqueous Solution

Lytkin

Chernikov

Krutova

et al. 2020

Russ. J. Phys. Chem.

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Section: Resultsmentioning

confidence: 99%

Standard Enthalpies of Formation of Isonicotinic Acid and Products of Its Dissociation in an Aqueous Solution

Lytkin

Chernikov

Krutova

et al. 2020

Russ. J. Phys. Chem.

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Rapid Synthesis of Schiff Bases via Pyridine‐2‐Carboxylic Acid as an Effective Catalyst

Vankar,

Makwana,

Sharma

2024

ChemistrySelect

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This work focuses on the rapid synthesis of Schiff bases with green protocols, where P2CA (Pyridine‐2‐carboxylic acid) is utilized as a catalyst. The condensation reaction of aldehydes and anilines, facilitated by P2CA, resulted in the production of Schiff bases in good to excellent yield within a remarkably short time of up to 15 min. The electronic effect of the various substituents on aldehyde and aniline, in combination with the catalytic effect of P2CA, accelerated the reactions under mild conditions. The reusability of the catalyst was thoroughly examined, and the catalyst was characterized over every cycle. Importantly, this approach is not only green and sustainable, but also cost‐effective, harmless, and environmentally friendly, thanks to the affordability and benign nature of P2CA.

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Ga(III) pyridinecarboxylate complexes: potential analogues of the second generation of therapeutic Ga(III) complexes?

Rendošová¹,

Gyepes²,

Sovová³

et al. 2023

J Biol Inorg Chem

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A series of novel Ga(III)—pyridine carboxylates ([Ga(Pic)3]·H2O (GaPic; HPic = picolinic acid), H3O[Ga(Dpic)2]·H2O (GaDpic; H2Dpic = dipicolinic acid), [Ga(Chel)(H2O)(OH)]2·4H2O (GaChel; H2Chel = chelidamic acid) and [Ga(Cldpic)(H2O)(OH)]2 (GaCldpic; H2Cldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis and X-ray diffraction confirmed complexes molecular structure, inter and intramolecular interactions and their influence to spectral and thermal properties. Moreover, complex species speciation was described in Ga(III)-HPic and Ga(III)-H2Dpic systems by potentiometry and 1H NMR spectroscopy and mononuclear complex species were determined; [Ga(Pic)2]+ (logβ021 = 16.23(6)), [Ga(Pic)3] (logβ031 = 20.86(2)), [Ga(Dpic)2]− (logβ021 = 15.42(9)) and [Ga(Dpic)2(OH)]2− (logβ-121 = 11.08(4)). To confirm the complexes stability in 1% DMSO (primary solvent for biological testing), timescale 1H NMR spectra were measured (immediately after dissolution up to 96 h). Antimicrobial activity evaluated by IC50 (0.05 mM) is significant for GaDpic and GaCldpic against difficult to treat and multi-resistant P. aeruginosa. On the other hand, the GaPic complex is most effective against Jurkat, MDA-MB-231 and A2058 cancer cell lines and significantly also decreases the HepG2 cancer cells viability at 75 and 100 μM concentrations in a relatively short time (up to 48 h). In addition, fluorescence measurements have been used to elucidate bovine serum albumin binding activity between ligands, Ga(III) complexes and bovine serum albumin. Graphical abstract

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Thermochemistry of the Acid-Base Interactions in Aqueous Solutions of Isonicotinic and Picolinic Acids

Cited by 10 publications

References 21 publications

Standard Enthalpies of Formation of Isonicotinic Acid and Products of Its Dissociation in an Aqueous Solution

Standard Enthalpies of Formation of Isonicotinic Acid and Products of Its Dissociation in an Aqueous Solution

Rapid Synthesis of Schiff Bases via Pyridine‐2‐Carboxylic Acid as an Effective Catalyst

Ga(III) pyridinecarboxylate complexes: potential analogues of the second generation of therapeutic Ga(III) complexes?

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