Thermochemotherapy Meets Tissue Engineering for Rheumatoid Arthritis Treatment (Adv. Funct. Mater. 40/2021)

Gang, Fangli; Zhang, Qin; Jiang, Le; Xiao, Yi; Xu, Nan; Wang, Yanling; Xiao, Yao; Li, Aijuan; Liu, Ziyu; Liu, Bo; Wu, Yanglin; X, Su; Perkins, Alexander Go; Wu, Qiong; Zhang, Jiwen; Lin, Jun; Sun, Xiaodan

doi:10.1002/adfm.202170295

Cited by 24 publications

(33 citation statements)

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“…Despite recent advances in understanding its pathogenesis, with many genetic susceptibility risk alleles identified, the etiology of RA remains elusive. [ 4–7 ] There is increasing evidence that the gut‐immune axis exerts a vital role in regulating RA. [ 8,9 ] The abundance of a variety of pathogenic bacteria, including Prevotella and segmental filamentous bacteria, is related to the severity of RA.…”

Section: Introductionmentioning

confidence: 99%

ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ‐Glutamylcysteine Level

Liu

Zhang

et al. 2022

Advanced Science

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Rheumatoid arthritis (RA) is an essential cause of labor loss and disability for people worldwide. Acanthopanax senticosus polysaccharide (ASPS) is one of the most important active components from A. senticosus , which exhibits various pharmacological activities such as antioxidation and immunomodulation. However, no studies have reported the application of ASPS in treating RA. This study aims to investigate the therapeutic effect of ASPS on RA and reveal its underlying mechanism. The potential therapeutic effect of ASPS against RA is initially verified in this study using the collagen‐induced arthritis model. Moreover, the protective benefits of ASPS are transmitted through the fecal microbiota and blocked by simultaneous antibiotic cocktail treatment, indicating that gut microbiota may be correlated with ASPS. The 16S rRNA sequencing using feces samples and untargeted UPLC‐MS metabolomics using serum samples further reveal that ASPS reprograms the arthritic progression triggered dysbiosis, enhances the expression of γ ‐glutamylcysteine (GGC) synthetase, and enriches the serum concentration of GGC. Furthermore, metabolites GGC is found to be able to effectively interrupt NLRP3 inflammasome activation via inhibiting ASC nucleation and therefore attenuate inflammatory arthritis. Taken together, this work highlights ASPS's therapeutic potential against RA, which mainly exhibits its effects via modulating gut microbiota and regulating GGC production.

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Section: Introductionmentioning

confidence: 99%

ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ‐Glutamylcysteine Level

Liu

Zhang

et al. 2022

Advanced Science

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“…[ 28 ] Considering that the elastic modulus of the peripheral nerve is around hundreds kPa, [ 28 ] hydrogel scaffolds should be adjusted to match natural nerve tissue. Based on previous work on hydrogels, [ 25,29 ] we improved the design of the immunohydrogels to possess neuro‐like biomechanical properties. The hydrogel sample (width* a marked length = 1 cm* 1 cm) can be stretched nearly 4 times, and a 20% deformation occurs when the stretching force is unloaded ( Figure a), indicating a good elastic restoration feature.…”

Section: Resultsmentioning

confidence: 99%

Biomechanically‐Adapted Immunohydrogels Reconstructing Myelin Sheath for Peripheral Nerve Regeneration

Wang

Yan

Liu

et al. 2022

Adv Healthcare Materials

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Myelin sheath reconstruction plays an important role in peripheral nerve regeneration. But the hindered reconstruction of myelin sheath, due to the inadequate repair phenotypes of macrophages and Schwann cells after peripheral nerve injury, often causes poor functional nerve recovery. Here, biomechanically-adapted immunohydrogels are prepared as the FK506-loaded platforms and nerve tissue engineering scaffolds to reconstruct myelin sheath for peripheral nerve regeneration. By immunofluorescent staining, an increase in the proportion of F4/80 + markers reveals that the biomechanically-adapted scaffolds facilitate recruitment of macrophages. Furthermore, the high Interleukin 10 (IL-10) mRNA expression level suggests the anti-inflammation learning effects of FK506 in vitro, which is further confirmed by a high CD206/TNF-𝜶 ratio in the FK506 Gel group in vivo. The immune learning effects are positively related to the increase in compactness and thickness of myelin sheath, indicating the synergy of structural reconstruction of myelin sheath and M2 phenotype polarization of macrophages. All these data indicate that the biomechanically-adapted immunohydrogels enhance recruitment of macrophages, educate M2 polarization of macrophages and promote a neuroprotective environment, which in consequence reconstructs myelin sheath for peripheral nerve regeneration.

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“…Recently, Gang et al successfully combined thermochemotherapy with tissue engineering to eliminate inflammation and regenerate RA-induced cartilage defects [ 125 ]. They loaded the anti-rheumatic drug methotrexate (MTX) and transforming growth factor β1 (TGFβ1) into the multifunctional double network hydrogel constructed by nano-Fe 3 O 4 composite chitosan polyolefin (DN-Fe-MTX-TGFβ1).…”

Section: Application Of Engineered Mscs In Autoimmune Diseasesmentioning

confidence: 99%

Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

Zhu

Yang

et al. 2023

Stem Cell Res Ther

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Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad.

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Thermochemotherapy Meets Tissue Engineering for Rheumatoid Arthritis Treatment (Adv. Funct. Mater. 40/2021)

Cited by 24 publications

References 0 publications

ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ‐Glutamylcysteine Level

ASPS Exhibits Anti‐Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ‐Glutamylcysteine Level

Biomechanically‐Adapted Immunohydrogels Reconstructing Myelin Sheath for Peripheral Nerve Regeneration

Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

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