Thermodilution Cardiac Output Determinations in Small Infants

Zideman, David; Rimmer, Martin; Williams, William G.; Steward, David J.

doi:10.1097/00000542-197909001-00320

Cited by 6 publications

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“…Complete depression of the initial twitch of the train-of-four occurred in all patients given atracurium 0.5 mg kg" 1 (table III). The trend towards faster onset times in neonates and infants compared with children may be explained by the rapid circulation time in these patients [19] and the shorter distribution half-life of atracurium in infants [20]. Time to 95% depression of twitch height is important because intubation can easily be carried out at this degree of neuromuscular blockade [21].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Atracurium-Induced Neuromuscular Blockade in Neonates, Infants and Children

Meakin

Shaw

Baker

et al. 1988

British Journal of Anaesthesia

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The potency of atracurium was determined in neonates, infants and children during thiopentone-fentanyl-nitrous oxide in oxygen anaesthesia using single dose-response curves. The effective doses producing 50% depression of the first twitch of the train-of-four were significantly lower in neonates and infants than in children (82 and 112 v. 135 micrograms kg-1). Following a standard dose of atracurium 0.5 mg kg-1, 95% depression of the first twitch occurred more rapidly in neonates than in children (0.9 v. 1.4 min), while recovery to 10% of the control twitch height occurred more rapidly in neonates than in the other two groups (22.7 v. 29.7 and 28.6 min). It is concluded that neonates and infants require less atracurium to produce a given degree of neuromuscular blockade compared with older children. However, prompt recovery can be expected in all healthy paediatric patients following a standard intubating dose of atracurium 0.5 mg kg-1.

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Section: Discussionmentioning

confidence: 99%