The present study focuses on the organic Rankine cycle (ORC) integrated into an evacuated tube heat pipe (ETHP), whose systems are an alternative solar energy system to low-efficiency planary collectors. In this work, a detailed thermodynamic and artificial neural network (ANN) analysis was conducted to evaluate the solar energy system. One of the key parameters of sustainable approaches focused on exergy efficiency is application of thermal engineering. In addition to this, sustainable engineering approaches nowadays are a necessity for improving the efficiency of all of the engineering research areas. For this reason, the ANN model is used to forecast different types of energy efficiency problems in thermodynamic literature. The examined system consists of two main parts such as the ETHP system and the ORC system used for thermal energy production. With this system, it is aimed to evaluate energy and exergy analysis results by the ANN method in the case of integrating the ORC system to ETHP, which is one of the planar collectors suitable for the roofs of the buildings. Within the scope of this study, the exergy efficiency was evaluated on the developed ANN algorithm. The effect rates of parameters such as pressure, temperature and ambient temperature affecting the exergy efficiency of ORC integrated ETHP were calculated. Ambient temperature was found to be the most influential parameter on exergy efficiency. The exergy efficiency of the whole system has been calculated as ~23.39%. The most suitable BPNN architecture for this case study is recurrent networks with dampened feedback (Jordan–Elman nets). The success rate of the developed BPNN model is 95.4%.