Thermodynamic analysis of the solubility of progesterone in 1-octanol + ethanol cosolvent mixtures at different temperatures

Torres-Cardozo, Andrea; Cerquera, Néstor Enrique; Ortíz, Claudia Patricia; Osorio-Gallego, Jhonny; Cardenas-Torres, Rossember Edén; Angarita-Reina, Fredy; Martínez, Fleming; Delgado, Daniel Ricardo

doi:10.1016/j.aej.2022.08.035

Cited by 4 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The measurement of the solubility in each mixture was performed according to the shake-flask method proposed by Higuchi and Connors [29], which consists of four phases: (1) saturation, (2) phase separation (filtration), (3) quantification (UV/Vis), and (4) solid phase analysis. This method is sufficiently described in some works conducted and published by the research group [20,30].…”

Section: Solubility Determinationmentioning

confidence: 99%

Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures

et al. 2023

Self Cite

View full text Add to dashboard Cite

The current challenges of the pharmaceutical industry regarding the environmental impact caused by its waste have led to the design and development of more efficient industrial processes. In this context, solubility studies are at the core of different processes, such as formulation, preformulation, synthesis, purification, recrystallization, quantification, and quality control. This research evaluates the solubility of sulfamerazine (SMR) in acetonitrile + 1-propanol cosolvent mixtures at nine temperature levels with UV/vis spectrophotometry using the vial-shake method. According to the analysis of the solid phase in equilibrium using differential scanning calorimetry, there were no polymorphic changes. The minimal solubility of SMR was reached in 1-propanol at 278.15 K, and the maximal solubility in acetonitrile at 313.15 K. In all cases, the process was endothermic and dependent on the cosolvent composition, and the solution enthalpy drove the solution process. The solubility data were well correlated with the van’t Hoff, Yalkowsky–Roseman–van’t Hoff, Apelblat, Buchowski–Ksiazczak λh, Yaws, NRTL, Wilson, and modified Wilson models, with the YR model being one of the most attractive because it presented an excellent prediction percentage from four sets of experimental data. The solution process of SMR in acetonitrile + 1-propanol cosolvent mixtures depends on the affinity of SMR for acetonitrile and temperature increase.

show abstract

Section: Solubility Determinationmentioning

confidence: 99%

Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Due to the low solubility of PP in water, solubility studies in organic solvents and cosolvent mixtures are crucial lines of research. These studies aim to devise strategies to improve PP solubility, considering the importance of this physicochemical property in processes, such as recrystallization, purification, quality analysis, quantification, preformulation studies and pharmaceutical dosage design [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures

et al. 2023

Self Cite

View full text Add to dashboard Cite

Parabens are substances used in the food, pharmaceutical and cosmetic industries. Recent studies have indicated that these substances have toxic potential, cause endocrine disruption and can easily bioaccumulate; therefore, their physicochemical properties are of industrial, biological and environmental interest. Due to their potential use in the development of more efficient and cleaner processes, the design of environmental recovery strategies and more reasonable designs for solubility in cosolvent mixtures, studies of thermodynamic analysis and mathematical modeling are of great interest. This research studies the solubility of propylparaben in acetonitrile + water cosolvent mixtures at nine temperatures by UV/Vis spectrophotometry, analyzing the solid phase by differential scanning calorimetry to evaluate possible polymorphic changes. The solubility of propylparaben is an endothermic process, where phase separation occurs at intermediate mixtures, reaching its minimum solubility in pure water at 278.15 K and the maximum solubility in pure acetonitrile at 315.15 K. The experimental data are well-correlated with the va not Hoff, Apelblat and Buchowski–Ksiazaczak models. The results revealed that possible microheterogeneity of the MeCN + W mixture can generate phase separation in intermediate mixtures, possibly due to the formation of solvates or hydrates.

show abstract

Transfer learning-driven artificial intelligence model for glass transition temperature estimation of molecular glass formers mixtures

Borredon,

Miccio,

Schwartz

2024

Computational Materials Science

View full text Add to dashboard Cite

Thermodynamic analysis of the solubility of progesterone in 1-octanol + ethanol cosolvent mixtures at different temperatures

Cited by 4 publications

References 56 publications

Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures

Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures

Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures

Transfer learning-driven artificial intelligence model for glass transition temperature estimation of molecular glass formers mixtures

Contact Info

Product

Resources

About