2019
DOI: 10.1016/j.molliq.2019.111507
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Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures

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Cited by 24 publications
(11 citation statements)
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“…The procedure was the same as that developed and published by this research group in previous research [18]. The quantification of the solubility of SMT in the MeCN + MeOH co-solvent mixtures was carried out according to the flask shaking method proposed by Higuchi and Connors [19].…”
Section: Solubility Determinationmentioning
confidence: 99%
“…The procedure was the same as that developed and published by this research group in previous research [18]. The quantification of the solubility of SMT in the MeCN + MeOH co-solvent mixtures was carried out according to the flask shaking method proposed by Higuchi and Connors [19].…”
Section: Solubility Determinationmentioning
confidence: 99%
“…Among the most often utilized are micronization [ 17 ], monocrystal formation [ 18 , 19 ], amorphization [ 20 , 21 , 22 ], complexation with cyclodextrins [ 23 , 24 ], solid dispersion formation [ 25 ], pH modification [ 26 , 27 ], formation of salts [ 28 , 29 ] and cocrystals [ 30 , 31 ]. The usage of hydrotropes or cosolvation techniques also offers an interesting and relatively simple way of enhancing solubility [ 32 , 33 ]. The cosolvation effect takes place when a particular amount of a cosolvent is added to the primary solvent and causes a solubility increase [ 34 ].…”
Section: Introductionmentioning
confidence: 99%
“…Many approaches have been proposed to address this challenge, including micronization [ 27 ], monocrystal formation [ 28 , 29 ], amorphization [ 30 , 31 , 32 ], complexation with cyclodextrins [ 33 , 34 ], solid dispersion formation [ 35 ], pH modification [ 36 , 37 ], formation of salts [ 38 , 39 ] and cocrystals [ 40 , 41 , 42 , 43 ]. A very promising and simple way of increasing solubility is the usage of cosolvation techniques [ 44 , 45 ]. The cosolvation effect is achieved when an addition of some amount of a particular solvent to the primary solvent results in increased solubility of the solute [ 46 ].…”
Section: Introductionmentioning
confidence: 99%