Thermodynamic and kinetic study of CaCl2-CH3OH adducts for solid sorption refrigeration by TGA/DSC

Korhammer, Kathrin; Neumann, Karsten; Opel, Oliver; Rück, Wolfgang

doi:10.1016/j.apenergy.2018.08.100

Cited by 7 publications

(3 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DSC has unique advantages in terms of its simplicity, rapidity, and ease of measurement providing direct information pertaining to the thermodynamic and kinetic properties associated with solid materials. 41 DSC is a prime technique to validate the purity of the material and understand phase transformations. Figure 5a shows the DSC thermograms of VLF−CA salt, VLF, CA, and their physical mixture.…”

Section: Introductionmentioning

confidence: 99%

Venlafaxine Caffeic Acid Salt: Synthesis, Structural Characterization, and Hypoglycemic Effect Analysis

Zhang

Cheng

et al. 2021

ACS Omega

View full text Add to dashboard Cite

Depression is a recurrent and chronic mental disorder requiring long-term treatment. Major depressive disorder is present in 15–20% of patients with type 1 or type 2 diabetes. Large-scale evidence revealed that depression and depressive symptoms are independent risk factors for the development of type 2 diabetes, and they may contribute to hyperglycemia and even accelerate the premature onset of diabetes complications. Venlafaxine is a clinical first-line antidepressant used for more than 30 years. Recently, clinical reports showed that venlafaxine overdose might cause hypoglycemia. Venlafaxine is insoluble and salt formation technology is the most appropriate method to improve the physicochemical properties and the pharmacokinetic profile of the drug. In the present work, the use of the solvent evaporation method, slurry, and the liquid-assisted grinding method resulted in the crystalline salt venlafaxine–caffeic acid (1:1). The compounds were characterized using a series of solid-state techniques, viz., powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and solid-state nuclear magnetic resonance, and the crystal structure was determined by single-crystal X-ray diffraction. Besides, a comparative study of solubility, dissolution, and hypoglycemic activity of the parent drug and the new salt has been carried out. The tested venlafaxine–caffeic acid salt showed about 16-fold higher solubility than the pure drug. Moreover, the glucose consumption assay results showed that the novel salt possesses potent hypoglycemic activity in vitro, suggesting that it is a promising candidate effective for major depressive disorder patients with type 2 diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Venlafaxine Caffeic Acid Salt: Synthesis, Structural Characterization, and Hypoglycemic Effect Analysis

Zhang

Cheng

et al. 2021

ACS Omega

View full text Add to dashboard Cite

show abstract

“…DSC experiments were performed on a Mettler Toledo DSC-1 instrument (Mettler Toledo, Greifensee, Switzerland) [63]. Samples weighing approximately 5-6 mg were sealed in aluminum pans and subjected to heating from 30 to 250 • C at a heating rate of 10 • C min −1 .…”

Section: Thermal Analysismentioning

confidence: 99%

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

Yu,

Zhang,

Liu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely, glutaric, vanillic, 2,6-dihydroxybenzoic, protocatechuic, and 3,5-dinitrobenzoic acids. Single-crystal X-ray diffraction analysis revealed that the hydroxyl/carboxylic acid. . .N-imidazole motif acts as the dominant supramolecular interaction in the obtained solid forms. The solubility of ketoconazole in distilled water significantly increased from 1.2 to 2165.6, 321.6, 139.1, 386.3, and 191.7 μg mL−1 in the synthesized multi-component forms with glutaric, vanillic, 2,6-dihydroxybenzoic, protocatechuic, and 3,5-dinitrobenzoic acid, respectively. In particular, the cocrystal form with glutaric acid showed an 1800-fold solubility increase in water concerning ketoconazole. Our study provides an alternative approach to improve the solubility and modify the release profile of poorly water-soluble drugs such as ketoconazole.

show abstract

“…Recently, Wu et al [5] studied a prototype of low-grade heat thermochemical sorption cooling with an EG-SrCl2/NH3 pair, producing a cooling effect with a temperature ranging from − 15 to 5 • C, with desorption temperatures below 100 • C and a reactor cooling temperature of 25 • C. Korhammer et al [6] analyzed the thermodynamics and kinetics of the CaCl2-CH3OH pair, using TGA/DSC. They found that, for applications with evaporator temperatures close to 10 • C, SCP are obtained between 157 W/kg and 366 W/kg and COP between 0.9 and 0.76, for cycles of 60 min.…”

Section: Introductionmentioning

confidence: 99%

Modeling and experiments on a finned cylindrical reactor with expanded graphite/activated carbon/lithium chloride-ammonia for chemisorption refrigeration systems

Pérez

Romero

Albis

et al. 2021

Applied Thermal Engineering

View full text Add to dashboard Cite

Thermodynamic and kinetic study of CaCl2-CH3OH adducts for solid sorption refrigeration by TGA/DSC

Cited by 7 publications

References 127 publications

Venlafaxine Caffeic Acid Salt: Synthesis, Structural Characterization, and Hypoglycemic Effect Analysis

Venlafaxine Caffeic Acid Salt: Synthesis, Structural Characterization, and Hypoglycemic Effect Analysis

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

Modeling and experiments on a finned cylindrical reactor with expanded graphite/activated carbon/lithium chloride-ammonia for chemisorption refrigeration systems

Contact Info

Product

Resources

About