Thermodynamic reversibility of phase transitions. Specific effects of alcohols on phosphatidylcholines

Rowe, Elizabeth S.

doi:10.1016/0005-2736(85)90248-2

Cited by 162 publications

(96 citation statements)

References 35 publications

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“…This reconfirmed the absence of interdigitation of hydrocarbon chains in the presence of ethanol. It should be noted that the lack of biphasic dependence on ethanol concentration was also reported in the literature for Pes 28 , phosphatidylserine PS 36 , and PCs with large C values 32 , where C is the effective acyl chain length difference between the sn-1 and sn-2 acyl chains. On the other hand, ethanol binding to the lipid-water interface of phospholipid bilayers may significantly altered the orientation of the bilayer headgroups and disordered the entire lengths of the hydrocarbon chains 37 .…”

Section: Ethanol Effect On the Thermotropic Phase Transition Of Ipa Bsupporting

confidence: 70%

Effects of Ethanol and Cholesterol on Thermotropic Phase Behavior of Ion-Pair Amphiphile Bilayers

et al. 2017

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Section: Ethanol Effect On the Thermotropic Phase Transition Of Ipa Bsupporting

confidence: 70%

Effects of Ethanol and Cholesterol on Thermotropic Phase Behavior of Ion-Pair Amphiphile Bilayers

et al. 2017

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“…PEs are not susceptible to alcohol-induced interdigitation [48] or pressure-induced interdigitation [55]. Even the ether-linked DHPE does not interdigitate with pressure [34,56].…”

Section: Phosphatidylethanolaminesmentioning

confidence: 99%

“…For instance, this difference is clear with nbutanol but not tert-butanol [15]. A property that accompanies the biphasic effect is the emergence of hysteresis in the main transition [15,16,48,49]. The hysteresis as it relates to DSC is defined as the difference in the transition temperature between heating and cooling scans.…”

Section: Chemically-induced Interdigitation Of Phosphatidylcholinesmentioning

confidence: 99%

“…This corresponds to the reversibility and kinetics of the transition. The return to the interdigitated phase with a decrease in temperature is a slow process and is therefore less reversible [48,51]. For systems that do not interdigitate, such as phosphatidylethanolamine (PE) lipids, the addition of alcohol does not affect the transition hysteresis [48].…”

Section: Chemically-induced Interdigitation Of Phosphatidylcholinesmentioning

confidence: 99%

“…It is consistently easier to interdigitate ether-linked lipids whether through chemical means [17,48,49] or by the application of pressure [51,61]. Furthermore, the etherlinked 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamine (DHPE) demonstrates the result of competing influences on the interdigitated gel phase.…”

Section: Spontaneous Interdigitation In Ether-linked Lipids and 13-dppcmentioning

confidence: 99%

See 2 more Smart Citations

Differential Scanning Calorimetry Studies of Phospholipid Membranes: The Interdigitated Gel Phase

Smith¹,

Dea²

2013

Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microca

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Acyl chain packing properties of deuterated lipid bilayer dispersions: Vibrational Raman spectral parameters

Devlin

Levin

1990

J Raman Spectroscopy

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The phase, packing and dynamic behavior of model membrane systems consisting of lipids with completely deuterated chains is generally monitored by the temperature dependeuce of the line width of the methylene (CD,) symmetric stretching modes located at -2100 cm-'Alternative empirical spectral parameters derived from the peak-height intensity ratios of spectral features assto the chain C-D methylene and methyl stretching modes are introduced and evaluated. In particular, specific intensity ratios reflect a sensitivity to average inter-and intra-chain order4sorder properties of the portions of the lipid chains localized either near the methyl termini or near the head-groupacyl chain interface. The utility of these intensity parameters is evaluated by examining the bilayer behavior of binary mixtures of dipahnitoylphosphatidylcholine with fully deuterated lipid chains (DPPCJI,,) and dirlmitoylpbosphatidylebolioe with nondeuterated &ins (DPPC-do) in various physical states. We also assess the use of intensity parameters for clarifying the effects of ethanol on the inter-and intra-chain interactions of DPPCJI,, bilayers. In the DPPC-d,,-ethanol system particular emphasis is placed on the formation of the novel interdigitated chain gel phase.

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Thermodynamic reversibility of phase transitions. Specific effects of alcohols on phosphatidylcholines

Cited by 162 publications

References 35 publications

Effects of Ethanol and Cholesterol on Thermotropic Phase Behavior of Ion-Pair Amphiphile Bilayers

Effects of Ethanol and Cholesterol on Thermotropic Phase Behavior of Ion-Pair Amphiphile Bilayers

Differential Scanning Calorimetry Studies of Phospholipid Membranes: The Interdigitated Gel Phase

Acyl chain packing properties of deuterated lipid bilayer dispersions: Vibrational Raman spectral parameters

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