Thermodynamic study of crown ether–lithium/magnesium complexes based on benz-1,4-dioxane and its homologues

Oral, Iklima; Ott, Fanny; Abetz, Volker

doi:10.1039/d2cp01076c

Cited by 5 publications

(7 citation statements)

References 47 publications

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“…The interaction of crown ether with a cation is based on the interaction of charge (the metal cation) and dipole (donor atom within the crown ether ring) which can be influenced by the orientation of the donor atom, cavity size of the crown ether, type of donor atom, the substitution of the electron donating and withdrawing compounds and solvents. [11] In comparison to common laboratories, serum lithium is estimated mainly by ion selective electrode methods which work mainly on the principle of generation potential difference between the electrodes. [12] Ikkurthi S et al in their study have concluded that plain vacutainers with clot activators show higher bias and statistically significant higher levels of Li than glass vacutainers [13].…”

Section: Discussionmentioning

confidence: 99%

“…They have the ability to crown metal cations. Silicone particles(cations) present in the clot activator vacutainers may have interfered with the crown ethers resulting in decreased value of serum lithium [11].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Sahu¹,

Sahoo²,

Chatterjee³

et al. 2023

Preprint

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Background: The collection of blood samples in different vacutainers can affect the result of serum lithium estimation due to the presence of distinct additives added in the blood collection vacutainer for enhancing the clot formation process. The presence of these additives has proven to interfere with laboratory results of biochemical analytes. In this case, both the pre-analytical and the analytical phases have a significant impact on the accuracy and precision of the test result. Thus, it has become a challenge for the lab physician to estimate lithium in any clinical laboratory setup. Materials and Methods: In total, 100 patient samples were collected and paired into clot activator vacutainers and plain glass vials. Both the paired collecting tubes after centrifugation were processed immediately via Vitros 4600 analyzer working on the principle of reflectance photometry. Both the paired tubes were stored at 2-8 degrees centigrade and were further analyzed, at 24 and 48 hours respectively, from the time of their collection. The statistical analysis was done in IBM SPSS software version 23. Results: There was a significant difference in the lithium values obtained from clot activator vacutainers in comparison to glass vial. The difference between the measurements of the lithium levels was statistically tested by t test where it was observed that the lithium measurements by the two different collecting tubes differed significantly with a Confidence Interval of 0.03 to 0.06 implying the level of agreement of both the methods are not similar. But there was no statistical difference in the lithium values estimated at 24 hours and 48 hours of collection. Conclusion: In this study, lithium levels measured by clot-activated vacutainers are found to be low as compared to lithium levels measured through glass vials. There is no apparent change in lithium values obtained at 1hr, 24hrs and 48hrs from their collection, when measured from the glass vials and the clot-activated vacutainers respectively, by the Vitros 4600 dry chemistry analyzer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Sahu¹,

Sahoo²,

Chatterjee³

et al. 2023

Preprint

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“…The intensity of the dye is measured by reflectance spectrophotometry at 600 nm.9-11 The interaction of crown ether with a cation is based on the interaction of charge (the metal cation) and dipole (donor atom within the crown ether ring) that can be influenced by the orientation of the donor atom, cavity size of the crown ether, type of donor atom, the substitution of the electron donating, and withdrawing compounds and solvents. 12 In comparison to other laboratories, serum Li is routinely estimated by ISE methods that work mainly on the principle of generation potential difference between the electrodes. 13 Ikkurthi et al in their study have concluded that plain vacutainers with clot activators show higher bias and statistically significant higher levels of Li than glass vacutainers.…”

Section: Discussionmentioning

confidence: 99%

“…Silicone particles(cations) present in the clot activator vacutainers may have interfered with the crown ethers resulting in decreased value of serum Li. 12 Vacutainers supplied by different manufacturers vary in the materials and additives that can potentially affect the test performance. Silicone surfactant-coated vacutainers have been shown to interfere with ion-specific electrode measurement of not only Li but also of ionized magnesium through interaction with ion-specific electrode membranes leading to increase in the measured voltage.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Serum Lithium Estimation Using Plain Glass Vial and Serum Clot Activator Vacutainer by Reflectance Photometry

et al. 2023

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Background The collection of blood samples in different vacutainers can affect the result of serum lithium estimation due to the presence of distinct additives in the blood collection vacutainer for enhancing the clot formation process. Due to the low therapeutic index and threat of toxicity of lithium, it is imperative to correctly report the test result. Thus, it has become a challenge for the laboratory physician to estimate lithium in any clinical laboratory setup. Materials and Methods Sample of 100 patients were collected and paired into clot activator vacutainers and plain glass vials. After centrifugation, samples from the paired collection tubes were processed immediately for serum lithium estimation by VITROS 4600 analyzer working on the principle of reflectance photometry. Both the paired tubes were stored at 2 to 8°C and were further analyzed, at 24 and 48 hours, respectively, from the time of their collection. The statistical analysis was done in IBM SPSS software version 23. Results There was a statistically significant differences between the mean of lithium values when processed within 1st hour of collection, obtained from clot activator vacutainers in comparison to glass vials. However, within tube comparison, there was no statistical difference in the lithium values estimated at 1st hour, 24 hours, and 48 hours of collection. Conclusion In this study, lithium values measured by clot-activated vacutainers are found to be lower as compared with values measured through glass vials.

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Advancements in Atomically Precise Nanocluster Protected by Thiacalix[4]arene

Gupta,

Wang,

Mohan

et al. 2024

Advanced Materials

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Coinage metal nanoclusters (NCs), comprising a few to several hundred atoms, are prized for their size‐dependent properties crucial in catalysis, sensing, and biomedicine. However, their practical application is often hindered by stability and reactivity challenges. Thiacalixarene, a macrocyclic ligand, shows promise in stabilizing silver, copper, and bimetallic NCs, enhancing their structural integrity and chemical stability. This investigation delves into the unique properties of thiacalix[4]arene and their role in bolstering NC stability, catalytic efficiency, and sensing capabilities. The current challenges and future prospects are critically evaluated, underscoring the transformative impact of thiacalix[4]arene in nanoscience. This review aims to broaden the utilization of atomically precise coinage metal NCs, unlocking new avenues across scientific and industrial applications.

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Thermodynamic study of crown ether–lithium/magnesium complexes based on benz-1,4-dioxane and its homologues

Abstract: The decrease of hydrophobicity within the crown ether ring improves the selectivity of lithium to magnesium.

Cited by 5 publications

References 47 publications

Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Comparative Evaluation of Serum Lithium Estimation Using Plain Glass Vial and Serum Clot Activator Vacutainer by Reflectance Photometry

Advancements in Atomically Precise Nanocluster Protected by Thiacalix[4]arene

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