Thermodynamic study of the solubility of ethylparaben in acetonitrile + water cosolvent mixtures at different temperatures

Antibacterial, antifungal, and antiviral activities of chalcone-bearing tetrahydropyranyl and 2,4-dihydroxyl moieties

“…Enthalpy-entropy compensation graph Δ soln H o vs Δ soln G o for the solution process of SD, SMR and SMT (3) in {octanol (1) + methanol (2)} cosolvent mixtures at 294.12 K. Figure 8 shows that sulfonamides (SD, SMR and SMT) in {OcOH (1) + MeOH(2)} cosolvent mixtures at 294.12 K presents a non-linear Δ soln H° vs. Δ soln G° curve. SD, it presents a positive slope throughout the curve, indicating an enthalpic conduction; SMR, presents an enthalpy-driven (positive slope) [40] in mixtures OcOH-rich and intermediate and an entropy-driven (negative slope) [40] in mixtures MeOH-rich; finally the SMT, presents an entropy-driven (negative slope) in mixtures OcOHrich and in mixtures MeOH-rich, and an enthalpy-driven in intermediate mixtures (positive slope).…”

Thermodynamic analysis and preferential solvation of gatifloxacin in DMF + methanol cosolvent mixtures

“…The standard thermodynamic functions of the solution (table 4) are calculated from the experimental solubility data and study temperatures. Thus, the mathematical expressions of Gibbs and van't Hoff, under Krug's approach, are presented as follows [4,34,35]:…”

“…Thus, according to the Perlovich plot [4,37,39,41,42], from pure methanol to w 0.10 (Sector III Δ tr H° < 0, TΔ tr S° > 0, and |TΔ tr S°| > |Δ tr H°|) the process is driven by entropy; from w 0.10 to w 0.20 (Sector V Δ tr H° < 0, TΔ tr S° < 0, and |TΔ tr S°| < |Δ tr H°|) the process is driven by enthalpy; from w 0.20 to w 0.40 (Sector IV Δ tr H° < 0, TΔ tr S° > 0, and |TΔ tr S°| < |Δ tr H o |), the process is again driven by enthalpy; from w 0.40 to w 0.50 (Sector III Δ tr H° < 0, TΔ tr S° > 0, and |TΔ tr S°| > |Δ tr H o |) the process is driven by entropy; from w 0.50 to w 0.70 (Sector IV Δ tr H° < 0, TΔ tr S° > 0, and |TΔ tr S°| < |Δ tr H°|), the process is driven by enthalpy and from w 0.70 to pure DMF (Sector V Δ tr H° < 0, TΔ tr S° < 0, and |TΔ tr S°| < |Δ tr H°|) the process continues to be driven by enthalpy.…”

“…In addition, the pharmaceutical industry is a potential source of contamination, since most processes, such as synthesis, purification of raw materials, chemical analysis for quality assessment, and pre-formulation and formulation studies, tend to produce large masses of waste containing these chemical agents [4,5].…”

Thermodynamic analysis and preferential solvation of gatifloxacin in DMF + methanol cosolvent mixtures

“…Thus, according to the Perlovich plot[4,37,39,41,42], from pure methanol to w 0.10 (Sector III Δ tr H° < 0, TΔ tr S° > 0, and |TΔ tr S°|…”