Thermodynamics of adsorption of binary aqueous organic liquid mixtures on a RPLC adsorbent

Gritti, Fabrice; Guiochon, Georges

doi:10.1016/j.chroma.2007.04.024

Cited by 65 publications

(52 citation statements)

References 16 publications

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“…ϕ ACN,pore is defined as the average volume fraction of acetonitrile inside the mesoporous volume of the particles at equilibrium. Pulse techniques to measure adsorption isotherms has been investigated in depth [7,39,40,10,13]. Knox and Kaliszan have shown that the corrected (for the inter-particle volume) elution volume, V R , of a pulse of organic modifier in a column equilibrated with the binary eluent of volume fraction ϕ ACN,bulk in the organic solvent is given by [7]:…”

Section: Excess Adsorption Isothermmentioning

confidence: 99%

“…It is important to note that n e ACN is unique and is directly accessible by minor disturbance experiments on a plateau [8][9][10]41,11]:…”

Section: Excess Adsorption Isothermmentioning

confidence: 99%

“…Thermodynamic data have been acquired by chromatography regarding the excess (or deficiency) of adsorption of the solvent molecules in both RPLC [7][8][9][10][11][12][13] and in HILIC [14]. Retention factor and adsorption isotherms of small analytes have been accurately measured in order to refine previously proposed mechanisms of retention [5,15].…”

Section: Introductionmentioning

confidence: 99%

“…Secondly, the density profiles of acetonitrile are unambiguously determined from its actual excess adsorption isotherm. This isotherm is measured by the minor disturbance method [8][9][10][11][12][13] for 5 m 96Å Symmetry particles in equilibrium with a series of aqueous mobile phases containing from 5% to 95% acetonitrile in volume. The impact of these semi-empirical density profiles on the retention mechanism of charged, polar, and apolar analytes is discussed.…”

Section: Introductionmentioning

confidence: 99%

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Determination of the solvent density profiles across mesopores of silica-C18 bonded phases in contact with acetonitrile/water mixtures: A semi-empirical approach

Gritti

2015

Journal of Chromatography A

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Section: Excess Adsorption Isothermmentioning

confidence: 99%

“…It is important to note that n e ACN is unique and is directly accessible by minor disturbance experiments on a plateau [8][9][10]41,11]:…”

Section: Excess Adsorption Isothermmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of the solvent density profiles across mesopores of silica-C18 bonded phases in contact with acetonitrile/water mixtures: A semi-empirical approach

Gritti

2015

Journal of Chromatography A

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“…In the binary system, when increase of the water adsorption with pressure is higher than increase of acetonitrile adsorption, water molecules may displace acetonitrile molecules from the surface of the stationary phase. The displacement may be illustrated by following equation (Gritti and Guiochon 2007):…”

Section: Influence Of the Flow Rate On The Solvent Adsorptionmentioning

confidence: 99%

Influence of temperature and pressure on the preferential adsorption of component of hydroorganic mobile phase in liquid chromatography

2010

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The excess isotherms of methanol and acetonitrile were measured on the series of C18 bonded phases. The measurements were done using the minor disturbance method. The goal of our work was to determine the influence of the temperature on the adsorption of two commonly used solvents. The influence on the mobile phase flow rate on the both organic solvent adsorption was also investigated. The effect of these two parameters was compared on the octadecyl packed columns with different coverage density and on the monolithic Chromolith column. Adsorption of both solvents decreases with the increase of the temperature. The increase of the pressure increases adsorption of methanol but decreases adsorption of acetonitrile.

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Examination of the surface heterogeneity of reversed‐phase packing materials with solvent adsorption

Vajda

Bocian

Buszewski

et al. 2010

J of Separation Science

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The adsorption isotherms of acetonitrile, ethanol, 2-propanol, and THF were measured using frontal analysis on six columns packed with octadecyl RP stationary phase. The effect of the bonding density of the end-capped octadecyl bonded phase on the adsorption properties was measured. Adsorption isotherm data were collected from aqueous solutions of the four organic modifiers. The isotherm model for solvent adsorption was selected using two independent parameter estimation methods, the regression analysis and adsorption energy distribution. The fitted isotherm parameters were tested by modeling of overloaded elution bands with the aid of the equilibrium-dispersive model of chromatography. The surface heterogeneity estimations and the effect of the silanol groups on the adsorption of solvents were based on those data.

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Thermodynamics of adsorption of binary aqueous organic liquid mixtures on a RPLC adsorbent

Cited by 65 publications

References 16 publications

Determination of the solvent density profiles across mesopores of silica-C18 bonded phases in contact with acetonitrile/water mixtures: A semi-empirical approach

Determination of the solvent density profiles across mesopores of silica-C18 bonded phases in contact with acetonitrile/water mixtures: A semi-empirical approach

Influence of temperature and pressure on the preferential adsorption of component of hydroorganic mobile phase in liquid chromatography

Examination of the surface heterogeneity of reversed‐phase packing materials with solvent adsorption

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