Thermodynamics of aromatic amino acid interactions with heterocyclic ligands

Tyunina, E. Yu.; Badelin, V. G.; Mezhevoi, I. N.; Тарасова, Г. Н.

doi:10.1016/j.molliq.2015.07.024

Cited by 18 publications

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References 34 publications

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“…Nicotinic acid, also known as niacin, vitamin B3, and antileprosy factor, is one of the indispensable nutrients for the human body that acts as an antioxidant and plays an important role in promoting normal growth and development. − It is also an important hydrogen transporter and antileprosy factor in body tissues and can maintain skin and nerve health and promote digestion . Moreover, as a clinical drug, nicotinic acid can reduce the concentration of blood cholesterol, triglycerides, and β-lipoprotein. − Importantly, it is a well-established drug that is used as a vasodilator in the treatment of ischemic heart disease. Owing to the multiple effects of nicotinic acid, many researchers are interested in it and have devoted extensive research effort to it and achieved valuable results. ,,− For example, Pan et al and Yang et al .…”

Section: Introductionmentioning

confidence: 99%

Volumetric, Viscometric, and Refractive Index Studies of Drug Nicotinic Acid in Aqueous d-Xylose/l-Arabinose Solutions from 293.15 to 313.15 K: Insights into Solute–Solute and Solute–Solvent Interactions

et al. 2022

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The densities and viscosities of nicotinic acid in pure water and aqueous d-xylose/l-arabinose solutions at temperatures from 293.15 to 313.15 K and the refractive indices of these mixed solutions at 298.15 K were measured under atmospheric pressure. Furthermore, these experimentally measured values of density were used to calculate the apparent molar volume, limiting partial molar volume, and transfer partial molar volume. The Jones–Dole coefficients, namely, viscosity B coefficients, and the variation of B coefficients with temperature were calculated from the experimentally measured values of viscosity according to the Jones–Dole equation. The experimentally measured refractive indices were used to calculate the molar refractions. The above-mentioned parameters and their variation trends are discussed in terms of solute–solute and solute–solvent interactions. The results show that nicotinic acid plays a structure-breaking role in the aqueous carbohydrate solutions studied herein.

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