Thermodynamics of Solutions IV: Solvation of Ketoprofen in Comparison with other NSAIDs

Thermodynamics of partitioning and solvation of ketoprofen in some organic solvent: buffer and liposome systems

“…Finally, it will be very important to analyze the surface behavior of this drug in other organic systems such as micelles, in order to evaluate if KTP is amphiphilic in nature, as it was demonstrated for ibuprofen. Reported by Perlovich et al (2003).…”

“…Similar equations have been used recently in order to evaluate the relative contributions by enthalpy and entropy to the free energy of solvation of some nonsteroidal anti-inflammatory drugs studying the solution process in several solvents (Perlovich et al, 2003(Perlovich et al, , 2004. The respective contributions for all the partitioning systems evaluated are also presented in table IV.…”

“…In order to obtain quantities that can be discussed solely in terms of drug-organic medium interactions, the contributions of drug-water must be removed. This can be accomplished by referring to hypothetic processes presented in (14) Table V shows the standard thermodynamic functions of solvation of KTP in water presented by Perlovich et al (2003). The same table present also the standard thermodynamic functions of solvation of this drug in all organic phases studied, including the respective contributions by enthalpy and entropy toward solvation in each medium (calculated by means of expressions analogous to equations (9) and (10)).…”

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…Physicians prescribe ketoprofen to individuals suffering with osteoarthritis and rheumatoid arthritis to manage pain and inflammation. There have been several published studies 60,64,65,100,[131][132][133][134][135][136][137][138][139][140][141][142][143] involving the solubility of ketoprofen in organic solvents at 298 K. Most notably, Perlovich et al 136 determined the molefraction solubility of ketoprofen in eight primary alcohols (methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol, and 1-octanol). Daniels et al 134 later reported the solubility behavior of ketoprofen in ethyl ethanoate, 1,1′-oxybisethane, methanol, ethanol, 1-propanol, 2-propanol, 2-methyl-1-propanol, 1-pentanol, and 1-decanol.…”

Solvation and hydration characteristics of ibuprofen and acetylsalicylic acid

“…It is a continuation of work formerly done in the same field for nonsteroidal antiinflammatory drugs (NSAIDs). [3][4][5][6] In contrast to previous work, in which biphenyl derivatives (diflunisal [DIF] and flurbiprofen [FBP]) 4 naphthalene derivatives ([+]-naproxen) 5 and a derivative of benzophenone (ketoprofen) 6 were considered, in the present study, IBP and ASA were chosen as representatives of the same class of drugs (NSAIDs), but being phenyl derivatives ( Figure 1). This method enables the comparison of solvation characteristics of a wide spectrum of compounds using quantitative thermodynamic parameters derived from experimental data.…”