Thermodynamics of the interaction between Keplerate-type polyoxometalate {Mo72Fe30} and vitamin B1

Tonkushina, M. O.; Belozerova, K.A.; Gagarin, I.D.; Adamova, L. V.; Terziyan, T. V.; Русских, О. В.; Остроушко, А. А.

doi:10.1016/j.tca.2022.179201

Cited by 7 publications

(10 citation statements)

References 75 publications

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“…This allows us to estimate the rate constant as 3.3×10 −4 s −1 . The rate constant of pure POM destruction in such a media is 2.2×10 −3 s −1 [58] . Therefore, the coordination of DOX with the POM slows down the destruction.…”

Section: Resultsmentioning

confidence: 98%

“…Moreover, different biocompatible polymers can be used: polyvinylpyrrolidone, polyethylene glycol [58–60] . However, two additional matters should be mentioned.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, different biocompatible polymers can be used: polyvinylpyrrolidone, polyethylene glycol. [58][59][60] However, two additional matters should be mentioned. First, in real blood protein coronae can form around the nanoparticles, forcing out the drug and making the therapy less targeted.…”

Section: Chemistryselectmentioning

confidence: 99%

“…The rate constant of pure POM destruction in such a media is 2.2 × 10 À 3 s À 1 . [58] Therefore, the coordination of DOX with the POM slows down the destruction. For comparison, the rate constant of {Mo 72 Fe 30 } destruction in associate with albumin is 4.4 × 10 À 5 s À 1 .…”

Section: Chemistryselectmentioning

confidence: 99%

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The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

et al. 2022

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This article studies the binding of the antitumor drug doxorubicin (DOX) with the nanocluster polyoxometalate (POM) {Mo 72 Fe 30 }, the latter serving as the drug carrier. The formation of a stoichiometric complex POM@(DOX) 12 was observed in aqueous media. Using the Stern-Volmer technique, we found the binding constant and free Gibbs energy for this interaction. The produced complex POM@(DOX) 12 was examined with ultraviolet-visible (UV-Vis), fluorescence (steady state and life-time), infrared (IR) and X-ray photoelectron spectro-scopy (XPS), which revealed the stoichiometry of complex and a key role of {Mo 3 Fe 3 } host pores on the POM surface to DOX binding. DOX's ability to intercalate into DNA after binding with the {Mo 72 Fe 30 } was investigated using a pH typical for blood (7.4). A pH-dependent release of DOX from POM@-(DOX) 12 was demonstrated (rate constant is 3.3 × 10 À 4 s À 1 ). Finally, we showed that the immobilization of doxorubicin on the POM's surface can reduce undesired side effects.

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Section: Resultsmentioning

confidence: 98%

“…Moreover, different biocompatible polymers can be used: polyvinylpyrrolidone, polyethylene glycol [58–60] . However, two additional matters should be mentioned.…”

Section: Resultsmentioning

confidence: 99%

Section: Chemistryselectmentioning

confidence: 99%

Section: Chemistryselectmentioning

confidence: 99%

See 2 more Smart Citations

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

et al. 2022

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“…On the other hand, one of the most challenging issues in nano-biotechnological studies is the lack of effective and safe carriers in drugs delivery 4 – 6 . Many compounds with specific properties have been used for drug delivery so far, notably polyoxometalates (POMs) are also among them 7 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Controlled drug delivery and cell adhesion for bone tissue regeneration by Keplerate polyoxometalate (Mo132)/metronidazole/PMMA scaffolds

Taghiyar

Yadollahi

Kajani

2022

Sci Rep

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The aim of this study is to fabricate a new scaffold appropriate for tissue regeneration with antimicrobial activity and ability of controlled drug delivery. In this regard, scaffold nanofibers were produced using poly (methyl methacrylate) (PMMA), Mo132 as a Keplerate polyoxometalate and metronidazole. The final scaffolds, obtained by electrospinning, represent the intrinsic features including exceptional doubling tensile strength, high hydrophilicity (126 ± 5.2° to 83.9 ± 3.2° for contact angle and 14.18 ± 0.62% to 35.62 ± 0.24% for water uptake), proper bioactivity and cell adhesion. Moreover, the addition of Mo132 and metronidazole enhances the biodegradation rate of resulted scaffolds compared to the pure PMMA membrane. The controlled release of metronidazole over 14 days efficiently inhibits the colonization of anaerobic microorganisms. Overall, the results demonstrate high potential of Mo132 and metronidazole-loaded PMMA scaffold for guided bone regeneration/guided tissue regeneration.

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A Heterogeneous Phosphomolybdate Nanocatalyst Utilizes Vitamin B1 to Promote Solvent‐Free H₂O₂ Sulfoxidation Selectivity

Nakhaei,

Rezaeifard,

Jafarpour

et al. 2024

Applied Organom Chemis

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Catalyst design and fabrication with safe and affordable components and methods is a high‐value‐added business. In this work, a vitamin‐based hybrid nanomaterial (PMoB1) is prepared by simple stirring of thiamine hydrochloride (vitamin B1, VB1) as an inexpensive commercially available biologically active compound with phosphomolybdic acid (PMo12) in acidic aqueous solution to catalyze selective oxidation of sulfides using aqueous H2O2. A small amount of this heterogeneous catalyst drives rapidly the sulfoxidation reaction under mild and solvent‐free conditions facilitating the product separation and reducing significantly the environmental impacts. The main factors of the catalytic reaction were optimized by the central composite design (CCD) method. The solid catalyst tolerates a wide range of pH and retained its structural integrity even at alkaline solution (pH = 11). PMoB1 composed of two VB1 and one PMo12 was found to be partially reduced based on 13P NMR and UV–Vis spectra. An amorphous structure with aggregated nanoparticles with sizes ranging between 50 and 70 nm and a specific surface area of 35 m2/g are important reasons for enhanced catalytic activity and selectivity. Nevertheless, non‐covalent interactions such as hydrogen bonding and the π–π stacking can also significantly affect the catalyst performance. Given the scavenging tests and spectral evidences, a non‐radical mechanism involving peroxo species is postulated. The catalysis is shown to be truly heterogeneous while the solid catalyst largely maintains its structural integrity during the recycling test.

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Thermodynamics of the interaction between Keplerate-type polyoxometalate {Mo72Fe30} and vitamin B1

Cited by 7 publications

References 75 publications

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

Controlled drug delivery and cell adhesion for bone tissue regeneration by Keplerate polyoxometalate (Mo132)/metronidazole/PMMA scaffolds

A Heterogeneous Phosphomolybdate Nanocatalyst Utilizes Vitamin B1 to Promote Solvent‐Free H₂O₂ Sulfoxidation Selectivity

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Thermodynamics of the interaction between Keplerate-type polyoxometalate {Mo72Fe30} and vitamin B1

Cited by 7 publications

References 75 publications

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo72Fe30}‐Based Ensembles

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo72Fe30}‐Based Ensembles

Controlled drug delivery and cell adhesion for bone tissue regeneration by Keplerate polyoxometalate (Mo132)/metronidazole/PMMA scaffolds

A Heterogeneous Phosphomolybdate Nanocatalyst Utilizes Vitamin B1 to Promote Solvent‐Free H2O2 Sulfoxidation Selectivity

Contact Info

Product

Resources

About

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo₇₂Fe₃₀}‐Based Ensembles

A Heterogeneous Phosphomolybdate Nanocatalyst Utilizes Vitamin B1 to Promote Solvent‐Free H₂O₂ Sulfoxidation Selectivity