Thermodynamics of the second-stage dissociation of n-(2-acetamido)iminodiacetic acid in water from 5 to 55°c

Thermodynamics of the second-stage dissociation of 2-[N-(2-hydroxyethyl)-N-methylaminomethyl]-propenoic acid (HEMPA) in water at different ionic strength and different solvent mixtures

“…Other investigators reported similar results for (CAPS and CAPSO) [6], (BES) [7], (ACES and CHES) [8], TRICINE [9], TES [10], ADA [11,12], (HEPPS and MOPSO) [13], (MOPS) [14], and (MOBS and HEPBS) [15]. These studies have provided precise knowledge about the thermodynamic quantities associated with the dissociation process as well as about the suitability of a biological buffer.…”

Medium effect on the second-stage dissociation constant of N-(2-acetamido)imino diacetic acid (H2ADA)

“…Zwitterionic buffers, comparable to amino acids, show significant advantages over conventional buffers: insignificant penetration through biological membrane, maximum buffer capacity at physiological pH range 6-8.50, and no enzyme substrate or enzyme inhibitor properties. Though studies on the dissociation constants of acids and bases in mixed and nonaqueous solvents have been extensive, relatively little work has been done to determine the dissociation constants of the biologically important zwitterionic buffers (3)(4)(5)(6)(7).…”

Dissociation Constant of N-(2-Acetamido)-Iminodiacetic Acid Monosodium (ADA) from (278.15 to 328.15) K

“…The analysis of the purified sample averaged 99.9%. The usual method of purification has been described earlier [6] [8]. From preliminary measurements the difference in emf data using both purified and unpurified ADA buffer was within ± 0.03 mV.…”

“…The pK 2 values have been determined at twelve temperatures from 278.15 to 328.15 K by measuring the emf of cell (B). At 298.15 K, the pK 2 is 6.8416 compared to 6.844 [6] using Ag-AgBr electrode. The results are in good agreement.…”

“…Included were 2-aminoethanoic acid (GLYCINE) [1], N-tris(hydroxymethyl)methylglycine (TRICINE) [2] and bis-[(2-hydroxyethyl)amino] acetic acid (BICINE) [3]. We have also studied thermodynamic quantities for the dissociation of a series of some substituted TAURINE such as N-tris[hydroxymethy]-4-aminoethanesulfonic acid (TABS) [4] and (3-[N-morpholino])]-2-hydroxypropanesulfonic acid (MOPSO) [5] from 278.15 to 328.15 K. In order to provide useful pH standard buffer for the control of acidity in the pH range 6.5 to 8.5, which is important for studies of clinical fluids and physiological media of ionic strength I = 0.16 mol•kg −1 , we have undertaken to study acid-base behavior, and to determine values for the second dissociation constant pK 2 and thermodynamic functions of N-(2-acetamido)iminodiacetic acid (ADA) in the temperature range 278.15 K to 328.15 K in an earlier publication [6]. The values of these quantities were reported by using a different galvanic cell without liquid junction of the type:…”