Patient with fully edentulous maxillaries often suffer of several disease as an alteration of facial appearance, difficulties in eating, speech, and chews. Fixed and removable prosthesis can be a solution to rehabilitate this issue. The All-on-Four protocol is one of the possible treatment modalities for implant-supported prosthetics. It consists of placing four implants in an intermorainal position, two perpendicular to the occlusal plane and two tilted distally at a 45° angle. This paper aims to assess the stress distribution on an All-on-Four titanium prosthesis by means of a Thermoelastic Stress Analysis (TSA). This full-field non-contact measurement technique allows, through a thermal imaging camera, to observe how the surface temperature of an object changes under the effect of cyclic load. The principle on which thermoelastic analysis is based is the existence of a relationship between deformation, hence applied stress, and temperature change, called the thermoelastic effect. To perform the tests, the prosthesis was fixed to a resin jaw cast that has similar characteristics to the human bone, so that the same damping that would be present under normal working conditions could be accounted for. The distal artificial molar tooth was kept in contact to a narrow screw, which was attached to a Medium-Force (M-Series) Air-Cooled Shakers made by Santek. This shaker generates a sinusoidal load of 800N with a load cell at 10 Hz frequency, which can maintain the temperature variation of the prosthesis constant. A pre-load was applied before starting the tests. To see the change in temperature a Flir A6751SC thermal camera was used, and videos were acquired with a frame rate of 125 Hz and a resolution of 640x512 pixels. From the experimental TSA tests, the trend of the experimental stress concentration on the titanium specimen was detected. The outcomes of the experimental tests were compared to a 3D prosthesis model by Finite Element Analysis (FEM).