Thermographic Imaging of Lungs Procured and Transported on Ice

Ahmed, Haseeb; Alayyar, M.; Jothidasan, A.; Husain, Mubassher; Zeschky, C.; Umakumar, Kabeer; Padukone, A.; Smail, Hassiba; Robertis, Fabio De; Stock, U.

doi:10.1016/j.healun.2022.01.1778

Cited by 1 publication

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“…One of the main disadvantages of SCS on ice is that the true temperature of the donor lung can significantly diverge from 4°C. A thermographic evaluation of donor lungs transported on ice showed that the surface temperature was non-homogenous and depending on preservation times ranged from 0.2°C to 10.6°C [ 12 ]. Consequently, temperature-controlled preservation devices, which use more accurate cool packs instead of ice cubes, have been developed.…”

Section: Lung Preservation At 10°cmentioning

confidence: 99%

The Advent of Semi-Elective Lung Transplantation—Prolonged Static Cold Storage at 10°C

Hoetzenecker,

Benazzo,

Schwarz

et al. 2024

Transpl Int

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Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static cold storage (SCS) in a cooler filled with ice. Depending on the length of SCS, organs usually arrive at the recipient hospital at a temperature of 0°C–4°C. The question of the optimal storage temperature for donor lung preservation has been revisited as data from large animal experiments demonstrated that organs stored at 10°C experience less mitochondrial damage. Thus, prolonged cold ischemic times can be better tolerated at 10°C—even in pre-damaged organs. The clinical applicability of these findings was demonstrated in an international multi-center observational study including three high-volume lung transplant centers. Total clinical preservation times of up to 24 hrs have been successfully achieved in organs stored at 10°C without hampering primary organ function and short-term outcomes. Currently, a randomized-controlled trial (RCT) is recruiting patients with the aim to compare standard SCS on ice with prolonged SCS protocol at 10°C. If, as anticipated, this RCT confirms data from previous studies, lung transplantation could indeed become a semi-elective procedure.

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Section: Lung Preservation At 10°cmentioning

confidence: 99%