Thermomechanically processed chitosan:gelatin films being transparent, mechanically robust and less hygroscopic

Chen, Ying; Duan, Qingfei; Yu, Long; Xie, Fengwei

doi:10.1016/j.carbpol.2021.118522

Cited by 40 publications

(15 citation statements)

References 39 publications

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“…Peaks at 2θ = 10 • and 2θ = 20 • are typical fingerprints of chitosan powder. When chitosan and gelatin are combined, the peak at 2θ = 8 • become flatter, thus indicating that the incorporation of chitosan results in a decreased crystallinity of gelatin [30] (Figure 5C). This can be attributed to hydrogen bonding between the two biopolymers which hinders the triple helix formation of gelatin.…”

Section: Xrd Of Each Scaffoldmentioning

confidence: 99%

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

et al. 2022

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Traumatic brain injuries (TBIs) are still a challenge for the field of modern medicine. Many treatment options such as autologous grafts and stem cells show limited promise for the treatment and the reversibility of damage caused by TBIs. Injury beyond the critical size necessitates the implementation of scaffolds that function as surrogate extracellular matrices. Two scaffolds were synthesised utilising polysaccharides, chitosan and hyaluronic acid in conjunction with gelatin. Both scaffolds were chemically crosslinked using a naturally derived crosslinker, Genipin. The polysaccharides increased the mechanical strength of each scaffold, while gelatin provided the bioactive sequence, which promoted cellular interactions. The effect of crosslinking was investigated, and the crosslinked hydrogels showed higher thermal decomposition temperatures, increased resistance to degradation, and pore sizes ranging from 72.789 ± 16.85 µm for the full interpenetrating polymer networks (IPNs) and 84.289 ± 7.658 μm for the semi-IPN. The scaffolds were loaded with Dexamethasone-21-phosphate to investigate their efficacy as a drug delivery vehicle, and the full IPN showed a 100% release in 10 days, while the semi-IPN showed a burst release in 6 h. Both scaffolds stimulated the proliferation of rat pheochromocytoma (PC12) and human glioblastoma multiforme (A172) cell cultures and also provided signals for A172 cell migration. Both scaffolds can be used as potential drug delivery vehicles and as artificial extracellular matrices for potential neural regeneration.

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Section: Xrd Of Each Scaffoldmentioning

confidence: 99%

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

et al. 2022

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“…The relatively poor thermomechanical stability is one of gelatin hydrogel's drawbacks, but chemical functionalization and modification increase the durability of these hydrogels, and make them suitable for long-term biological applications [170]. Of note, gelatin's functional groups, including primary amine, carboxyl, and hydroxyl, enable its modification with various cross-linkers and therapeutic agents, making it an ideal candidate for tissue regeneration [166].…”

Section: Gelatin-based Hydrogelsmentioning

confidence: 99%

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

et al. 2022

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The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents’ structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels’ structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted.

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“…Moreover, glycerol can induce flexibility in chitosan films, and it is highly biocompatible. [11,15,16] To enhance the mechanical and thermal properties of chitosan, the incorporation of nanomaterials has shown to have some advantages. Composites of chitosan with (nano)metals or (nano)metal oxides, such as iron (Fe), copper (Cu), silver (Ag), silicon (Si), zinc (Zn), zinc oxide (ZnO), titanium dioxide (TiO 2 ) and halloysites in the form of nanotubes, have been studied, while many enhance the antimicrobial activity of chitosan among others.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, glycerol can induce flexibility in chitosan films, and it is highly biocompatible. [ 11,15,16 ]…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation of Chitosan and WS₂ Nanotubes

Magee,

Xie,

Farris

et al. 2023

Adv Materials Inter

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The inclusion of tungsten disulphide nanotubes (WS2 NTs) in chitosan, plasticized with glycerol, facilitates the formation of a polyelectrolyte complex. The glycerol interrupts the intramolecular hydrogen bonding between chitosan chains allowing positively charged protonated amines of chitosan to form a complex with negatively charged oxygen ions chemisorbed to the tungsten atoms in defects. These interactions, with the unique mechanical and chemical properties of WS2 NTs, result in a chitosan film with superior properties relative to unfilled chitosan. Even at low WS2 NT loadings (≤1 wt%), the Young's modulus (E) increases by 59%, tensile strength (σ) by 40% and tensile toughness by 74%, compared to neat chitosan, without sacrificing ductility. Addition of highly dispersed WS2 NTs significantly improves the gas barrier properties of chitosan, with a 50% reduction in oxygen permeability, while the addition of both glycerol and WS2 NTs to chitosan effectively reduces the carbon dioxide permeability by 80% and the water vapor transmission rate by 90%. The intrinsic antimicrobial efficacy of chitosan against both Gram‐positive and Gram‐negative bacteria is enhanced on inclusion of WS2 NTs. Polyelectrolyte complexation of WS2 NTs and glycerol‐plasticized chitosan provides a cost‐effective, sustainable route to biodegradable films with desirable mechanical, gas barrier properties, and antimicrobial efficacy suitable for food packaging applications.

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Thermomechanically processed chitosan:gelatin films being transparent, mechanically robust and less hygroscopic

Cited by 40 publications

References 39 publications

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

Polyelectrolyte Complexation of Chitosan and WS₂ Nanotubes

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Thermomechanically processed chitosan:gelatin films being transparent, mechanically robust and less hygroscopic

Cited by 40 publications

References 39 publications

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

Polyelectrolyte Complexation of Chitosan and WS2 Nanotubes

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Product

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Polyelectrolyte Complexation of Chitosan and WS₂ Nanotubes