“…The contribution of biotechnology to the development of the concept of biorefinery is fundamental, but so is that of other technologies (chemistry, engineering...), which must be integrated as a whole in order to maximize their efficiency and competitiveness (Erickson et al, 2012;Larroche et al, 2017). In recent years, research into the improvement of biomass biotransformation processes was focused on the development of mixed cultures applicable in anaerobic digestion processes (Jiang et al, 2017;Moscoviz et al, 2018;Strazzera et al, 2018), the search for thermophilic microorganisms and thermostable enzymes applicable in simultaneous hydrolysis and fermentation processes (Patel et al, 2019;Sharma et al, 2019), the use of microorganisms producing enzymatic mixtures with industrial application (Guo et al, 2018;Prasad and Roy, 2018), the manipulation of the metabolism of microorganisms towards the synthesis of target products (i.e., alcohols, organic acis, etc.) in high concentration (Buschke et al, 2013;Heux et al, 2015;Gustavsson and Lee, 2016), among others.…”