Thermophysical properties of aqueous and frozen states of BSA/water/Tris systems

Study on the Unfrozen Water Quantity of Maximally Freeze-Concentrated Solutions for Multicomponent Lyoprotectants

“…Fitted a i for BSA was 0.3863 g water/g, close to the value of 0.35 g water/g obtained by Ling et al, 37 whereas smaller than the value of 0.4976 g water/g obtained by Inoue, 28 which was due to the large cooling and heating rates used in DSC measurement. The corresponding W 0 g value for BSA/water solutions was 72.13 wt%, which was comparatively larger than the value of 70 wt% obtained by Hottot et al 38 as the intersection of ice melting and glass transition curve.…”

Thermal conductivity of bovine serum albumin: A tool to probe denaturation of protein

“…[4][5][6][7][8]18 It has been reported that DSC studies of BSA reveal the thermodynamics of the protein associated with denaturation, specifically the change in specific heat and enthalpy near the denaturation temperature T d . [6][7][8] However, relatively less attention has been paid to k of BSA (k BSA ).…”

“…[6][7][8] However, relatively less attention has been paid to k of BSA (k BSA ). 18 Therefore, we measured k of aqueous solutions of BSA (k sol ) by varying T and pH to determine how denaturation affects thermal transport in the solutions. The measured k data were compared with the results of the DSC analysis, 7 with discussions on the correlation between k and the denaturation process.…”

Model predictive control during the primary drying stage of lyophilisation

“…The value used for the model parameters may be found in (Hottot, Daoussi and Andrieu, 2006b) and are summarized in the nomenclature with the model variables.…”