Thermopneumatic suction integrated microfluidic blood analysis system

Abstract

Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater strip that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing.

Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms

“…The standard separation process is centrifugation, as it is time-consuming and off-chip. It is not an ideal technique for microfluidic LOC devices [37]. Therefore, an effective and capillary-scale volume delivery system is expected to separate blood plasma and be integrated into the microfluidic sensing platform.…”

Passively Driven Microfluidic Device with Simple Operation for Quantitative Droplet LAMP Sssay for Point-of-Care Analysis

“…With the increasing threat of pandemic infectious diseases through globalization, it is clear that POCT combined with molecular technologies, such as nucleic acid amplification technique, applied to frontline clinical settings can assist in early-stage implementations for public healthcare 11 . In the development of general public diagnostic applications of POCT, the ideal properties are high sensor performance and low system complexity, which potentially benefit patient management and healthcare, infectious determination, and the limitation of disease spread and ensure low resource consumption and low costs [12][13][14][15][16][17] .…”