“Thermoregulation-dependent component” in pathophysiology of motor disorders in Parkinson's disease?

Meigal, Alexander; Lupandin, Yurij

doi:10.1016/j.pathophys.2005.02.001

Cited by 11 publications

(10 citation statements)

References 76 publications

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“…Cold was reported to intensify tremor in PD patients, especially with tremor-dominated form, while heat reportedly attenuated muscle rigidity (40). Nonetheless, cold exposure is likely not reliable for early diagnostics of PD due to its apparent unpleasantness and procedure requirements.…”

Section: Emg As a Potential Early Marker For Pdmentioning

confidence: 99%

Non-Linear EMG Parameters for Differential and Early Diagnostics of Parkinson’s Disease

Meigal¹,

Rissanen²,

Tarvainen³

et al. 2013

Front. Neurol.

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The pre-clinical diagnostics is essential for management of Parkinson’s disease (PD). Although PD has been studied intensively in the last decades, the pre-clinical indicators of that motor disorder have yet to be established. Several approaches were proposed but the definitive method is still lacking. Here we report on the non-linear characteristics of surface electromyogram (sEMG) and tremor acceleration as a possible diagnostic tool, and, in prospective, as a predictor for PD. Following this approach we calculated such non-linear parameters of sEMG and accelerometer signal as correlation dimension, entropy, and determinism. We found that the non-linear parameters allowed discriminating some 85% of healthy controls from PD patients. Thus, this approach offers considerable potential for developing sEMG-based method for pre-clinical diagnostics of PD. However, non-linear parameters proved to be more reliable for the shaking form of PD, while diagnostics of the rigid form of PD using EMG remains an open question.

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Section: Emg As a Potential Early Marker For Pdmentioning

confidence: 99%

Non-Linear EMG Parameters for Differential and Early Diagnostics of Parkinson’s Disease

Meigal¹,

Rissanen²,

Tarvainen³

et al. 2013

Front. Neurol.

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“…For example, hyperthermia and parkinsonism cooccur in neuroleptic malignant syndrome and serotonin syndrome (Gurrera, 2002;Mizuno et al, 2003). It is thought that parkinsonian rigidity and fever stem from a mechanism involving the balance of dopamine and serotonin in the basal ganglia and brainstem (Meigal and Lupandin, 2005). It is possible that MA-induced parkinsonism may depend on a disrupted thermoregulatory mechanism.…”

Section: Do Preclinical Studies Of Ma-induced Motor Abnormalities Tramentioning

confidence: 99%

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Caligiuri

Buitenhuys

2005

Neuropsychopharmacol

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This review summarizes the preclinical literature of the effects of methamphetamine (MA) on subcortical dopaminergic and GABAergic mechanisms underlying motor behavior with the goal of elucidating the clinical presentation of human MA-induced movement disorders. Acute and chronic MA exposure in laboratory animal can lead to a variety of motor dysfunctions including increased locomotor activity, stereotypies, diminished or enhanced response times, and parkinsonian-like features. With the exception of psychomotor impairment and hyperkinesia, MA-induced movement disorders are not well documented in humans. This review attempts to draw parallels between the animal and human changes in basal ganglia neurochemistry associated with MA exposure and offers explanations for why a parkinsonian phenotype is not apparent among individuals who use and abuse MA. Significant differences in the expression of neurotoxicity and presence of multiple environmental and pharmacologic confounds may account for the lack of a parkinsonian phenotype in humans despite evidence of altered dopamine function.

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“…Therefore, we assume that at loading conditions, besides these abnormally active “unwilled” motor units, some normally recruited motor units were also inhibited by DI. Passive heating has been already shown to inhibit spontaneous rest activity of motor units in PD patients (Meigal and Lupandin, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Parameters of Surface Electromyogram Suggest That Dry Immersion Relieves Motor Symptoms in Patients With Parkinsonism

et al. 2018

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Dry immersion (DI) is acknowledged as a reliable space flight analog condition. At DI, subject is immersed in water being wrapped in a waterproof film to imitate microgravity (μG). Microgravity is known to decrease muscle tone due to deprivation of the sensory stimuli that activate the reflexes that keep up the muscle tone. In contrary, parkinsonian patients are characterized by elevated muscle tone, or rigidity, along with rest tremor and akinesia. We hypothesized that DI can diminish the elevated muscle tone and/or the tremor in parkinsonian patients. Fourteen patients with Parkinson's disease (PD, 10 males, 4 females, 47–73 years) and 5 patients with vascular parkinsonism (VP, 1 male, 4 females, 65–72 years) participated in the study. To evaluate the effect of DI on muscles' functioning, we compared parameters of surface electromyogram (sEMG) measured before and after a single 45-min long immersion session. The sEMG recordings were made from the biceps brachii muscle, bilaterally. Each recording was repeated with the following loading conditions: with arms hanging freely down, and with 0, 1, and 2 kg loading on each hand with elbows flexed to 90°. The sEMG parameters comprised of amplitude, median frequency, time of decay of mutual information, sample entropy, correlation dimension, recurrence rate, and determinism of sEMG. These parameters have earlier been proved to be sensitive to PD severity. We used the Wilcoxon test to decide which parameters were statistically significantly different before and after the dry immersion. Accepting the p < 0.05 significance level, amplitude, time of decay of mutual information, recurrence rate, and determinism tended to decrease, while median frequency and sample entropy of sEMG tended to increase after the DI. The most statistically significant change was for the determinism of sEMG from the left biceps with 1 kg loading, which decreased for 84% of the patients. The results suggest that DI can promptly relieve motor symptoms of parkinsonism. We conclude that DI has strong potential as a rehabilitation method for parkinsonian patients.

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“Thermoregulation-dependent component” in pathophysiology of motor disorders in Parkinson's disease?

Cited by 11 publications

References 76 publications

Non-Linear EMG Parameters for Differential and Early Diagnostics of Parkinson’s Disease

Non-Linear EMG Parameters for Differential and Early Diagnostics of Parkinson’s Disease

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Parameters of Surface Electromyogram Suggest That Dry Immersion Relieves Motor Symptoms in Patients With Parkinsonism

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