Thermoregulation in hibernating mammals: The role of the “thyroid hormones system”

Frare, Carla; Williams, Cory T.; Drew, Kelly L.

doi:10.1016/j.mce.2020.111054

Cited by 19 publications

(6 citation statements)

References 81 publications

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“…The mechanism of tanycytes controlling TRH flux into portal capillaries is illustrated in another paper 67 . Therefore, tanycytes may modulate the effects of thyroid hormone on thermogenesis, which is significant for thermoregulation in hibernating mammals 68 . Other roles of hypothalamic thyroid hormone in energy balance regulation have been previously reviewed 69 .…”

Section: Thyroid Hormonementioning

confidence: 99%

Hypothalamic control of energy expenditure and thermogenesis

et al. 2022

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Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.

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Section: Thyroid Hormonementioning

confidence: 99%

Hypothalamic control of energy expenditure and thermogenesis

et al. 2022

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“…Hibernation requires regulated coordination at behavioral, physiological, and molecular levels prior to initiating dormancy, including energy storage, metabolic adaptations, and inhibition of reproductive function 6 , 7 . In contrast, aside from transient physiological and neuronal changes associated with arousals 8 , 9 , little attention has been placed on the potential for seasonal neuroendocrine remodeling across hibernation.…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel

et al. 2022

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Hibernation involves prolonged intervals of profound metabolic suppression periodically interrupted by brief arousals to euthermy, the function of which is unknown. Annual cycles in mammals are timed by a photoperiodically-regulated thyroid-hormone-dependent mechanism in hypothalamic tanycytes, driven by thyrotropin (TSH) in the pars tuberalis (PT), which regulates local TH-converting deiodinases and triggers remodeling of neuroendocrine pathways. We demonstrate that over the course of hibernation in continuous darkness, arctic ground squirrels (Urocitellus parryii) up-regulate the retrograde TSH/Deiodinase/TH pathway, remodel hypothalamic tanycytes, and activate the reproductive axis. Forcing the premature termination of hibernation by warming animals induced hypothalamic deiodinase expression and the accumulation of secretory granules in PT thyrotrophs and pituitary gonadotrophs, but did not further activate the reproductive axis. We suggest that periodic arousals may allow for the transient activation of hypothalamic thyroid hormone signaling, cellular remodeling, and re-programming of brain circuits in preparation for the short Arctic summer.

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“…The T b and metabolism are precisely regulated before and during hibernation. A hypothalamic neuronal circuit has been found to control the initiate and exit of the hypothermic/hypometabolic state in both hibernators [10] and non-hibernators [11][12].…”

Section: Neurohumoral Regulation Of T B and Metabolismmentioning

confidence: 99%

Mammalian hibernation: a unique model for medical research

Xing

Wang

2021

Frigid Zone Medicine

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Hibernation is an adaptive behavior for some small animals to survive cold winter. Hibernating mammals usually down-regulate their body temperature from ~37°C to only a few degrees. During the evolution, mammalian hibernators have inherited unique strategies to survive extreme conditions that may lead to disease or death in humans and other non-hibernators. Hibernating mammals can not only tolerant deep hypothermia, hypoxia and anoxia, but also protect them against osteoporosis, muscle atrophy, heart arrhythmia and ischemia-reperfusion injury. Finding the molecular and regulatory mechanisms underlying these adaptations will provide novel ideas for treating related human diseases.

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Thermoregulation in hibernating mammals: The role of the “thyroid hormones system”

Cited by 19 publications

References 81 publications

Hypothalamic control of energy expenditure and thermogenesis

Hypothalamic control of energy expenditure and thermogenesis

Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel

Mammalian hibernation: a unique model for medical research

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