Thermoresponsive curcumin/DsiRNA Nanoparticle Gels for the Treatment of Diabetic wounds: Synthesis and Drug Release

Katas, Haliza; Wen, Chai Yi; Siddique, Muhammad Irfan; Hussain, Zahid; Fadhil, Fatin Hanini Mohd

doi:10.4155/tde-2016-0075

Cited by 27 publications

(21 citation statements)

References 57 publications

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“…Thermosensitive hydrogel in the structure of curcumin-assembled gelatine microspheres was found to improve the capacity of drug release in a sustained manner to the diabetic wound and promoted the efficacy of healing via reducing redox stress and reversing MMP-9-provoked inhibition of cell migration in diabetic mice [202]. Katas and co-researchers formulated a pluronic F-127-based gel containing curcumin-PGT (prostaglandin transporter) DsiRNA chitosan nanoparticles to treat diabetic wounds [203]. Curcumin-loaded chitosan nanoparticles encapsulated into collagen-alginate complex have been designed for the treatment of diabetic wounds.…”

Section: Curcuminmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Curcuminmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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“…The negative charge on skin is deemed favorable to attract positively charged chitosan polymer moieties enabling adhesion and/or drug/nanoparticle penetration into the skin. Though nanoparticle size is inversely related to the chitosan concentration used in their fabrication, a situation where more free NH + 3 groups are available to react with TPP and having a chitosan concentration beyond 0.3% w/v are reported to increase the nanoparticle size [49,59,60]. Our findings were contradictory to this, where with the use of 0.4% w/v chitosan concentration, a slight decrease in the nanoparticle size (Student's t-test, p = 0.260) was observed which can be attributed to the chitosan of low molecular weight used in the nanoparticle fabrication [61] (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The molecular weight analysis of HMW and low molecular weight (LMW) chitosan was done using gel permeation chromatography (Waters 1515 Isocratic HPLC pump, Waters Corporation, Hertfordshire, UK) equipped with dual a wavelength absorbance detector (2487, Waters Corporation, Hertfordshire, UK) and an injector (Waters 717 Plus Autosampler, Waters Corporation, Hertfordshire, UK) by means of a refractive index detector (Waters 2414 refractive index detector) as previously reported [49]. A styragel HR 5 tetrahydrofuran (THF) column (5 µm, 10-5 Å, 7.8 mm × 300 mm, Waters, Hertfordshire, UK) was used with tetrahydrofuran (THF) as the mobile phase.…”

Section: Molecular Weight Analysis Of Chitosanmentioning

confidence: 99%

“…The ATR-FTIR spectra of HMW chitosan, LMW chitosan, TPP, pure curcumin and F2 nanoparticles are given in Figure 3. The principle peaks of chitosan were observed at 3358-3355 cm −1 which is mainly due to OH/NH stretching vibration, weaker bands between 2873-2871 cm −1 and 1587-1560 cm −1 corresponding to CH stretching and NH 2 groups, respectively, and at 1027 cm −1 which arises due to C-O-C stretching (Figure 3a-c) [49]. The curcumin principle peaks were observed at 3505-3504 cm −1 and 1625 cm −1 and 1507 cm −1 which corresponds to OH stretching and aromatic (C=C) stretching (Figure 3d) [56].…”

Section: Vibrational Spectroscopic Analysismentioning

confidence: 99%

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Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Basit

Amin

et al. 2020

Polymers

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Improved physicochemical properties of chitosan-curcumin nanoparticulate carriers using microwave technology for skin burn wound application are reported. The microwave modified low molecular weight chitosan variant was used for nanoparticle formulation by ionic gelation method nanoparticles analyzed for their physicochemical properties. The antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa cultures, cytotoxicity and cell migration using human dermal fibroblasts—an adult cell line—were studied. The microwave modified chitosan variant had significantly reduced molecular weight, increased degree of deacetylation and decreased specific viscosity. The nanoparticles were nano-sized with high positive charge and good dispersibility with entrapment efficiency and drug content in between 99% and 100%, demonstrating almost no drug loss. Drug release was found to be sustained following Fickian the diffusion mechanism for drug release with higher cumulative drug release observed for formulation (F)2. The microwave treatment does not render a destructive effect on the chitosan molecule with the drug embedded in the core of nanoparticles. The optimized formulation precluded selected bacterial strain colonization, exerted no cytotoxic effect, and promoted cell migration within 24 h post application in comparison to blank and/or control application. Microwave modified low molecular weight chitosan-curcumin nanoparticles hold potential in delivery of curcumin into the skin to effectively treat skin manifestations.

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“…Thermoresponsive materials change their physical properties or present conformational changes in response to temperature variations. These materials are used for biomedical applications including drug delivery and tissue engineering among many others [68][69][70][71][72]. However, the transition-state temperature depends on the solvent interaction with the polymer and the hydrophilic/hydrophobic balance.…”

Section: Thermoresponsive Materialsmentioning

confidence: 99%

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Municoy

Echazú

Antezana

et al. 2020

IJMS

153

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Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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Thermoresponsive curcumin/DsiRNA Nanoparticle Gels for the Treatment of Diabetic wounds: Synthesis and Drug Release

Abstract: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.

Cited by 27 publications

References 57 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

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