Thermoresponsive fluorinated polyacrylamides with low cytotoxicity

Bak, Jae Min; Kim, Kyungbin; Lee, Jieun; Park, Yong‐Jin; Yoon, Sang Sun; Jeong, Han Mo; Lee, Hyung‐il

doi:10.1039/c2py20747h

Cited by 37 publications

(28 citation statements)

References 21 publications

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“…Two approaches have been proposed to avoid this shortcoming: (i) to reduce cytotoxicity of PNIPAm gels by chemical modification [ 19 ], and (ii) to search for alternative temperature-sensitive gels with controllable VPTT [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

Drozdov

2021

Gels

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Biomedical applications of thermo-responsive (TR) hydrogels require these materials to be biocompatible, non-cytotoxic, and non-immunogenic. Due to serious concerns regarding potential toxicity of poly(N-isopropylacrylamide) (PNIPAm), design of alternative homo- and copolymer gels with controllable swelling properties has recently become a hot topic. This study focuses on equilibrium swelling of five potential candidates to replace PNIPAm in biomedical and biotechnological applications: poly(N-vinylcaprolactam), poly(vinyl methyl ether), poly(N,N-dimethyl amino ethyl methacrylate), and two families of poly(2-oxazoline)s, and poly(oligo(ethylene glycol) methacrylates). To evaluate their water uptake properties and to compare them with those of substituted acrylamide gels, a unified model is developed for equilibrium swelling of TR copolymer gels with various types of swelling diagrams. Depending on the strength of hydrophobic interactions (high, intermediate, and low), the (co)polymers under consideration are split into three groups that reveal different responses at and above the volume phase transition temperature.

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Section: Introductionmentioning

confidence: 99%

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

Drozdov

2021

Gels

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“…Of all the thermoresponsive polymers, poly( N ‐isopropylacrylamide) (PNIPAM), which exhibits the soluble‐to‐insoluble phase transition in water at LCST around 32 °C, is the most popular one. Various PNIPAM‐based thermoresponsive block copolymers have been prepared by the controlled radical polymerization techniques such as atom transfer radical polymerization, nitroxide‐mediated polymerization, and reversible addition‐fragmentation chain transfer (RAFT) polymerization . Besides linear thermoresponsive polymers, the nonlinear poly(meth)acrylates, for example, poly[oligo(ethylene glycol) methyl ether methacrylate], and polystyrenics, for example, poly[poly(ethylene glycol) methyl ether vinylphenyl] (PmPEGV), both of which have short poly(ethylene glycol) (PEG) side‐chains, are found to exhibit LCST in water.…”

Section: Introductionmentioning

confidence: 99%

Doubly thermoresponsive brush-linear-linear ABC triblock copolymer nanoparticles prepared through dispersion RAFT polymerization

Huo

Cui

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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Doubly thermoresponsive ABC brush-linear-linear triblock copolymer nanoparticles of poly[poly(ethylene glycol) methyl ether vinylphenyl]-block-poly(N-isopropylacrylamide)block-polystyrene [P(mPEGV)-b-PNIPAM-b-PS] containing two thermoresponsive blocks of poly[poly(ethylene glycol) methyl ether vinylphenyl] [P(mPEGV)] and poly(N-isopropylacrylamide) (PNIPAM) are prepared by macro-RAFT agent mediated dispersion polymerization. The P(mPEGV)-b-PNIPAM-b-PS nanoparticles exhibit two separate lower critical solution temperatures or phase-transition temperatures (PTTs) corresponding to the linear PNIPAM block and the brush P(mPEGV) block in water. Upon temperature increasing above the first and then the second PTT, the hydrodynamic diameter (D h ) of the triblock copolymer nanoparticles undergoes an initial shrinkage at the first PTT and the subsequent shrinkage at the second PTT. The effect of the chain length of the PNIPAM block on the thermoresponsive behavior of the triblock copolymer nanoparticles is investigated. It is found that, the longer chains of the thermoresponsive PNIPAM block, the greater contribution on the transmittance change of the aqueous dispersion of the triblock copolymer nanoparticles. Synthesis of the Brush-Linear P(mPEGV)-b-PNIPAM-TTCThe brush-linear P(mPEGV) 32 -b-PNIPAM-TTC diblock copolymer was prepared by RAFT polymerization employing the brush P(mPEGV) 32 -TTC as macromolecular RAFT agent SCHEME 1 The chemical structure of mPEGV.

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“…Below LCST, polymers are hydrophilic and exist as coils due to hydrogen bonding with surrounding water molecules; above LCST, they undergo a conformational change from coil to globule due to the disruption of hydrogen bonds. Poly( N ‐isopropylacrylamide) (PNIPAM) and their analogs are the most studied polymer due to their near body temperature LCST response at 32 °C. However, due to recent concerns on potential cytotoxicity of residual monomers and protein interactions with PNIPAM‐based copolymers, other classes of polymers such as polymethacrylates containing pendant oligo(ethylene oxide) (i.e., poly(oligo(ethylene oxide) monomethyl ether methacrylate, POEOMA) have been explored as a water‐soluble and biocompatible alternative …”

Section: Introductionmentioning

confidence: 99%

Dual Redox and Thermoresponsive Double Hydrophilic Block Copolymers with Tunable Thermoresponsive Properties and Self‐Assembly Behavior

Chan

Yee

et al. 2014

Macromol. Rapid Commun.

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The synthesis, tunable thermoresponsive properties, and self-assembly of dual redox and thermoresponsive double hydrophilic block copolymers having pendant disulfide linkages (DHBCss) are reported. Well-defined DHBCss composed of a hydrophilic poly(ethylene oxide) block and a dual thermo- and reduction-responsive random copolymer block containing pendant disulfide linkages are synthesized by atom transfer radical polymerization. Their lower critical solution temperature (LCST) transitions are adjusted through modulating pendant hydrophobic-hydrophilic balance with disulfide-thiol-sulfide chemistry. Further, these DHBCss derivatives are converted to disulfide-crosslinked nanogels at temperatures above LCST through temperature-driven self-assembly and in situ disulfide crosslinking. They exhibit enhanced colloidal stability and further reduction-responsive degradability, thus demonstrating versatility of dual thermo- and reduction-responsive smart materials.

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Thermoresponsive fluorinated polyacrylamides with low cytotoxicity

Cited by 37 publications

References 21 publications

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

Doubly thermoresponsive brush-linear-linear ABC triblock copolymer nanoparticles prepared through dispersion RAFT polymerization

Dual Redox and Thermoresponsive Double Hydrophilic Block Copolymers with Tunable Thermoresponsive Properties and Self‐Assembly Behavior

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