Thermoresponsive micelles from well‐defined block copolymers synthesized via reversible addition–fragmentation chain transfer polymerization

Liu, Bo; Perrier, Sébastien

doi:10.1002/pola.20785

Cited by 88 publications

(72 citation statements)

References 37 publications

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“…[23,64,65] As at least some examples with comparable block lengths exist in the literature, it is interesting to compare directly the findings of the thermally induced association of the (M2) q -(M1) 2p -(M2) q triblock copolymers of the BAB type with the reported behaviours of the analogous diblock copolymers (M1) p -(M2) q , or of the ABA triblock copolymers (M1) p -(M2) 2q -(M1) p with the inverted block sequence, respectively. The report of Liu and Perrier [66] on a set of polyM1-polyM2 diblock copolymers, including a sample (M1) 94 -(M2) 98 that can be regarded as a diblock analogue for our sample (M2) 121 -(M1) 242 -(M2) 121 , unfortunately focused mainly on solubilisation capacities. Nevertheless, association was reported above 40 8C without further specification, i.e., close to the thermal transition found for the BAB triblock.…”

Section: Dynamic Light Scatteringmentioning

confidence: 99%

Synthesis of Double‐Hydrophilic BAB Triblock Copolymers via RAFT Polymerisation and their Thermoresponsive Self‐Assembly in Water

Skrabania

Laschewsky

2008

Macro Chemistry & Physics

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Triblock copolymers of poly(N‐isopropylacrylamide)‐block‐poly(N,N‐dimethylacrylamide)‐block‐poly(N‐isopropylacrylamide) were synthesised via RAFT polymerisation using a symmetrical bistrithiocarbonate. Keeping the block length of the permanently hydrophilic middle block constant, the length of the poly(N‐isopropylacrylamide) block was varied broadly. The thermoresponsive aggregation of the polymers in water was studied by 1H NMR, turbidimetry, and dynamic light scattering. The complex aggregation behaviour was block length dependent and occurred under kinetic control. Importantly, different information on the hydrophilic‐hydrophobic transition of the poly(N‐isopropylacrylamide) block was obtained using the various analytical methods and could not be directly correlated.magnified image

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Section: Dynamic Light Scatteringmentioning

confidence: 99%

Synthesis of Double‐Hydrophilic BAB Triblock Copolymers via RAFT Polymerisation and their Thermoresponsive Self‐Assembly in Water

Skrabania

Laschewsky

2008

Macro Chemistry & Physics

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“…In particular, thermo-sensitive polymeric micelles have attracted much attention because of their potential application in the area of targeted drug delivery [3]. Because *Corresponding author (email: ceszhlm@mail.sysu.edu.cn) of the lower critical solution temperature (LCST) close to body temperature, poly(N-isopropylacrylamide) (PNIPAm) is one of the most studied polymer to prepared thermo-sensitive polymeric micelles [4][5][6][7][8][9][10][11]. However, there is another class of polymer that deserves attention with respect to the biocompatibility and biodegradability.…”

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confidence: 99%

Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer

et al. 2010

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A novel thermo-sensitive block glycopolymer based on peracetylated maltoheptaose (AcMH) and poly(2-ethyl-2-oxazoline) (PEtOz) was synthesized for the first time and characterized by hydrogen nuclear magnetic resonance ( 1 H NMR) spectroscopy and gel permeation chromatograph (GPC) analyses. To obtain such a block polymer, the dihydroxyl poly(2-ethyl-2-oxazoline) homopolymer (OH-PEtOz-OH) was first synthesized by cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EtOz), and then coupled with the peracetylated maltoheptaose having a free hydroxyl group at the reducing end (AcMH-OH) prepared from β-cyclodextrin. It was found that the obtained block polymer could self-assemble into nanosize spherical micelles with a distinct core-shell structure in aqueous solution triggered by its amphiphilic character without any organic solvent. The model drug indomethacin (IND) was efficiently loaded into the resultant polymeric micelles, which was confirmed by 1 H NMR spectra, transmission electron microscope (TEM) and dynamic light scattering (DLS) techniques. The release behavior of IND loaded micelles was well in response to the environmental temperature change. It is suggested that the resulting micelles might be a potential targeted carrier for drug delivery.amphiphilic block copolymer, oligosaccharide, poly(2-ethyl-2-oxazoline), self-assembly, drug delivery, thermo-sensitive Citation:Chen L Q, Zhang L M, Chen J J, et al. Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer.

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“…The various synthetic routes to obtain these 'smart' materials have been recently compiled by McCormick et al and will not be detailed here [79]. The different kinds of stimuliresponsive block copolymers can be classified according to their nature: Ĺ hydrophilic block copolymers that bear only one stimuli-responsive segment, either temperature responsive [80][81][82][83][84][85] or pH-and ionic strength responsive [83,[86][87][88][89][90][91][92], Ĺ hydrophilic block copolymers that bear two stimuli-responsive segments or 'schizophrenic' block copolymers [83,85,[93][94][95][96][97] and Ĺ amphiphilic block copolymers that bear one or several stimuli-responsive segments [39, 74-76, 83, 98-102].…”

Section: Drug Deliverymentioning

confidence: 99%

Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics?

Favier

Lambert

Charreyre

2008

Handbook of RAFT Polymerization

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IntroductionThe development of controlled/living ionic and radical polymerization techniques during the last decades represents a major breakthrough in polymer chemistry and polymer science. Since these techniques lead to the synthesis of a wide range of tailor-made macromolecular architectures, significant improvements are expected in the current or future application fields of polymers. The industrial impact will however depend on the versatility and applicability of each technique, and of course on the extra cost for the final product.In this context, controlled radical polymerizations (CRP) and especially the reversible addition-fragmentation chain transfer (RAFT) process [1-3] have attracted a lot of attention since they combine the advantages of conventional radical polymerization and living ionic polymerizations. Conventional radical polymerizations are cost-effective techniques, easy to process with a low sensitivity to water and oxygen and applicable to a wide range of monomers. In addition, CRP techniques result in a very efficient control over molecular weight (MW), molecular-weight distribution (MWD), microstructure, chain-end functionality and macromolecular architecture.As shown in the previous chapters of this handbook, the RAFT process appears as one of the most interesting CRP techniques. First, RAFT polymerization is very similar to conventional radical polymerization since it only requires the addition of a chain-transfer agent (CTA) in the medium. Second, RAFT is a very versatile process able to control the (co)polymerization of a large variety of monomers leading to a virtually unlimited macromolecular design library.As a consequence, RAFT polymerization is a well-suited and promising technique to prepare high-performance polymers for a wide range of applications. Indeed, an efficient control at the macromolecular level is a very important step to control and improve the macroscopic properties of the final materials ( Fig. 13.1).

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Thermoresponsive micelles from well‐defined block copolymers synthesized via reversible addition–fragmentation chain transfer polymerization

Cited by 88 publications

References 37 publications

Synthesis of Double‐Hydrophilic BAB Triblock Copolymers via RAFT Polymerisation and their Thermoresponsive Self‐Assembly in Water

Synthesis of Double‐Hydrophilic BAB Triblock Copolymers via RAFT Polymerisation and their Thermoresponsive Self‐Assembly in Water

Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer

Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics?

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