Thermoresponsive platforms for tissue engineering and regenerative medicine

Tekin, Halil; Sanchez, Jefferson G.; Tsinman, Tonia; Langer, Robert; Khademhosseini, Ali

doi:10.1002/aic.12801

Cited by 39 publications

(22 citation statements)

References 74 publications

(252 reference statements)

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“…The response time can be improved by adapting a very thin membrane with porous networks for increasing diffusion coefficient31. In addition, by shifting the LCST of the SIM or by utilizing other stimuli-responsive hydrogels which have faster responses to chemical, pH, light, or humidity, the pump can be further improved with more flexibility3233.…”

Section: Discussionmentioning

confidence: 99%

Compact and Thermosensitive Nature-inspired Micropump

Kim

Lee

2016

Sci Rep

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Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h · cm2 for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices.

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Section: Discussionmentioning

confidence: 99%

Compact and Thermosensitive Nature-inspired Micropump

Kim

Lee

2016

Sci Rep

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“…Following the first report on thermoresponsive liposomes, 10 considerable work has been done in the area of stimuli-responsive polymers. The applications of these systems have been developed in areas such as drug and gene delivery, 11,12 tissue engineering, 13 detection and sensing. 14 More recently, research has focused on materials with dual functionality, where two stimuli are combined.…”

Section: Introductionmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N'-methylenebis (acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43°C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43°C, thus confirming the dual stimuli switch.

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“…A change in temperature results in a change in the hydration state of the material [111,112]. If applied as surface films, this will affect the wettability and the morphology of the polymer film.…”

Section: External Stimulimentioning

confidence: 98%

Responsive Cell–Material Interfaces

Dhowre

Rajput

Russell

et al. 2015

Nanomedicine (Lond.)

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Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable contributions to the effort to incorporate dynamic and reversible elements into a biomaterial. This is particularly challenging for cell-material interactions that occur at an interface (biointerfaces); however, the design of responsive biointerfaces also presents opportunities in a variety of applications in biomedical research and regenerative medicine. This review will identify the requirements imposed on a responsive biointerface and use recent examples to demonstrate how some of these requirements have been met. Finally, the next steps in the development of more complex biomaterial interfaces, including multiple stimuli-responsive surfaces, surfaces of 3D objects and interactive biointerfaces will be discussed.

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Thermoresponsive platforms for tissue engineering and regenerative medicine

Cited by 39 publications

References 74 publications

Compact and Thermosensitive Nature-inspired Micropump

Compact and Thermosensitive Nature-inspired Micropump

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Responsive Cell–Material Interfaces

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