Thermoresponsive polymer nanocarriers for biomedical applications

Bordat, Alexandre; Boissenot, Tanguy; Nicolas, Julien; Tsapis, Nicolas

doi:10.1016/j.addr.2018.10.005

Cited by 316 publications

(251 citation statements)

References 138 publications

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“…While water-soluble polymers with a LCST have been widely studied [3][4][5][6][7], those with an UCST are more rare despite the recent increasing interest they received [8,9]. UCST polymers find applications in biomedicine [10] such as drug delivery [11][12][13], catalysis [14] and 3D-printed scaffolds [15]. This UCST behavior is promoted by either hydrogen bonding or Coulomb interactions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Zydziak

Iqbal

Chaumont

et al. 2020

European Polymer Journal

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Thermoresponsive polymers, undergoing a reversible chemical or physical change using temperature as stimulus, attract increasing interest in particular as adaptable biomaterials. Except for zwitterionic polymers, fully charged polymers require the presence of specific ions to exhibit an upper critical solution temperature (UCST) in water. Herein, we report the discovery of an UCST in pure water for fully cationic comb polymers based on oligoarginine pendent grafts. These polymers were prepared using an original strategy based on solid-phase peptide synthesis of pentaarginine methacrylate-based macromonomer and its polymerization through reversible addition-fragmentation chain transfer. Despite their cationic nature, guanidinium groups from the arginine have the ability to self-associate at low temperature through hydrophobic interactions into stacked pair configuration defying the expected Coulomb interactions. These results pave the way to biomedical applications such as antimicrobial materials and drug delivery systems through the tuning of the polymer structure.

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Section: Introductionmentioning

confidence: 99%

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Zydziak

Iqbal

Chaumont

et al. 2020

European Polymer Journal

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“…Polymeric NPs can sense and respond to environmental changes via different chemical and physical mechanisms that often originate from dynamic hierarchical architectures. [77] Internal triggers, including pH, redox potential, temperature, and ionic strength permit temporally and spatially controlled drug delivery. [67,78] For instance, pH responsiveness is one of the most extensively exploited triggers, as pH values vary between different tissues and cellular compartments.…”

Section: Bodipy Nano-photosensitizers Prepared From Polymer Encapsulamentioning

confidence: 99%

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Sun

Zhao

Fan

et al. 2019

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As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY‐containing nano‐photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano‐photosensitizers demonstrate a promising potential for fighting cancer. This review contains three sections, classifying photodynamic therapy (PDT), photothermal therapy (PTT), and the combination of PDT and PTT based on BODIPY nano‐photosensitizers. It summarizes various BODIPY nano‐photosensitizers, which are prepared via different approaches including molecular precipitation, supramolecular interactions, and polymer encapsulation. In each section, the design strategies and working principles of these BODIPY nano‐photosensitizers are highlighted. In addition, the detailed in vitro and in vivo applications of these recently developed nano‐photosensitizers are discussed together with future challenges in this field, highlighting the potential of these promising nanoagents for new tumor phototherapies.

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“…Thermoresponsive polymers, which undergo significant modification of their solubility in water with temperature, have grown in interest for various applications, including biomedical, cosmetic, and food industries. [ 1–3 ] Polymers exhibiting a conformational transition from coil to globule above a critical temperature called lower critical solution temperature are certainly the most widely investigated ones. [ 4–6 ] In the opposite, polymers that are insoluble in water and become soluble above a critical temperature called upper critical solution temperature (UCST) are strangely less described in the literature.…”

Section: Figurementioning

confidence: 99%

Synthesis of Thermoresponsive Copolymers with Tunable UCST‐Type Phase Transition Using Aqueous Photo‐RAFT Polymerization

Lertturongchai

Ibrahim

Durand

et al. 2020

Macromol. Rapid Commun.

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H-acceptor sites, which are able to form intra-molecular reversible hydrogen bonds (globule conformation below UCST) and inter-molecular bonds with water (coil conformation above UCST). [11][12][13][14][15][16][17][18][19][20][21] The non-ionic polymers have attracted a great deal of attention due to their insensitivity to salts, which make them more attractive for applications in physiological environment. [22][23][24] During the last decade, efforts have been focused toward developing novel water-soluble copolymers exhibiting UCST behavior by copolymerizing H-donor monomers (N-acryloyl glycinamide [11][12][13][14][15][16] or acrylamide [15,[17][18][19][20][21]25] ) and H-acceptor monomers (acrylonitrile, [11,15,18,19,21,25,26] styrene, [15,17] and butyl acrylate [15] ). Such (co)polymers have been mainly prepared using free radical polymerization [11,[14][15][16][17]26] and by thermally initiated controlled radical polymerization such as atom transfer radical polymerization [13] and reversible addition fragmentation chain transfer (RAFT) [11,12,[16][17][18][19]25] The impacts of various parameters on the UCST phase transition, including salts, pH, molecular weight, molecular weight distribution, and chemical composition, have been well evaluated. [7][8][9]25,27] However, such studies were carried out at low polymer concentrations (below 5 wt%). This could induce, an unintentional confusion between the UCST and the apparent cloud point temperature (T CP ), which refers to the temperature at which the phase transition occurs depending on the investigated concentration level. The UCST of a given polymer in solution is obtained from an isobaric phase diagram where T CP are plotted versus the polymer concentrations. [7][8][9] T CP should increase with the polymer concentrations up to a maximum temperature, called UCST, before going down again.In this context, we envisioned to use aqueous photo-mediated RAFT (photo-RAFT) polymerization that would be able to prepare well-controlled UCST-type copolymers directly in water at very high concentration. Although photo-RAFT [28][29][30][31][32][33] has grasped great interests due to its versatility, rapidity, and ability to produce well-controlled polymers, it has never been employed for the synthesis of UCST-type polymers. This study provides new insight into UCST-type copolymers and aims to develop facile approach to investigate such kind of thermoresponsive behavior, less described in the literature currently.

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Thermoresponsive polymer nanocarriers for biomedical applications

Cited by 316 publications

References 138 publications

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Synthesis of Thermoresponsive Copolymers with Tunable UCST‐Type Phase Transition Using Aqueous Photo‐RAFT Polymerization

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