Thermoresponsive, Pyrrolidone‐Based Antifouling Polymer Brushes

Teunissen, Lucas W.; Kuzmyn, Andriy R.; Ruggeri, Francesco Simone; Smulders, Maarten M. J.; Zuilhof, Han

doi:10.1002/admi.202101717

Cited by 18 publications

(33 citation statements)

References 81 publications

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“…QCM is an established analytical technique that has been widely used to either assess the extent of protein adsorption onto polymer brushes or examine their anti-biofouling performance. − In QCM measurements, adsorption modifies the resonant frequency of the quartz crystal sensor. This change in frequency, Δ f , is proportional to the mass of adsorbed material, m .…”

Section: Results and Discussionmentioning

confidence: 99%

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Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications

Brotherton

Johnson

Smallridge³

et al. 2023

Macromolecules

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Surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) is used to polymerize a cis-diol-functional methacrylic monomer (herein denoted GEO5MA) from planar silicon wafers. Ellipsometry studies indicated dry brush thicknesses ranging from 40 to 120 nm. The hydrophilic PGEO5MA brush is then selectively oxidized using sodium periodate to produce an aldehyde-functional hydrophilic PAGEO5MA brush. This post-polymerization modification strategy provides access to significantly thicker brushes compared to those obtained by surface-initiated ARGET ATRP of the corresponding aldehyde-functional methacrylic monomer (AGEO5MA). The much slower brush growth achieved in the latter case is attributed to the relatively low aqueous solubility of the AGEO5MA monomer. X-ray photoelectron spectroscopy (XPS) analysis confirmed that precursor PGEO5MA brushes were essentially fully oxidized to the corresponding PAGEO5MA brushes within 30 min of exposure to a dilute aqueous solution of sodium periodate at 22 °C. PAGEO5MA brushes were then functionalized via Schiff base chemistry using an amino acid (histidine), followed by reductive amination with sodium cyanoborohydride. Subsequent XPS analysis indicated that the mean degree of histidine functionalization achieved under optimized conditions was approximately 81%. Moreover, an XPS depth profiling experiment confirmed that the histidine groups were uniformly distributed throughout the brush layer. Surface ζ potential measurements indicated a significant change in the electrophoretic behavior of the zwitterionic histidinefunctionalized brush relative to that of the non-ionic PGEO5MA precursor brush. The former brush exhibited cationic character at low pH and anionic character at high pH, with an isoelectric point being observed at around pH 7. Finally, quartz crystal microbalance studies indicated minimal adsorption of a model globular protein (BSA) on a PGEO5MA brush-coated substrate, whereas strong protein adsorption via Schiff base chemistry occurred on a PAGEO5MA brush-coated substrate.

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Section: Results and Discussionmentioning

confidence: 99%

“…This change in frequency, Δ f , is proportional to the mass of adsorbed material, m . The simplest model relating Δ f to m is the Sauerbrey equation, which is often used to calculate the mass of adsorbed protein. ,, …”

Section: Results and Discussionmentioning

confidence: 99%

Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications

Brotherton

Johnson

Smallridge³

et al. 2023

Macromolecules

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“…Polymer brushes are high-density systems that are covalently attached to surfaces. , Coatings based on polymer brushes are extensively used to create antifouling, bioactive, and antibacterial surfaces. − The high density of the polymer chains in the coating on the surfaces gives unique properties for the final layer. ,, The most commonly used method for constructing polymer brushes is surface-initiated atom transfer radical polymerization (SI-ATRP), due to the high control and possibility to initiate growth from a self-assembled monolayer. , However, SI-ATRP requires the use of heavy metals, typically copper, as catalysts. Moreover, the need for rigorous deoxygenation to achieve polymerization makes this approach difficult to scale and experimentally challenging to apply.…”

Section: Introductionmentioning

confidence: 99%

“… 19 , 20 Coatings based on polymer brushes are extensively used to create antifouling, bioactive, and antibacterial surfaces. 21 − 37 The high density of the polymer chains in the coating on the surfaces gives unique properties for the final layer. 19 , 38 , 39 The most commonly used method for constructing polymer brushes is surface-initiated atom transfer radical polymerization (SI-ATRP), due to the high control and possibility to initiate growth from a self-assembled monolayer.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating

et al. 2022

Self Cite

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This work presents a novel route for creating metalfree antiviral coatings based on polymer brushes synthesized by surface-initiated photoinduced electron transfer-reversible addition−fragmentation chain transfer (SI-PET-RAFT) polymerization, applying eosin Y as a photocatalyst, water as a solvent, and visible light as a driving force. The polymer brushes were synthesized using N- [3-(decyldimethyl)-aminopropyl] methacrylamide bromide and carboxybetaine methacrylamide monomers. The chemical composition, thickness, roughness, and wettability of the resulting polymer brush coatings were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle measurements, and ellipsometry. The antiviral properties of coatings were investigated by exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and avian influenza viruses, with further measurement of residual viable viral particles. The best performance was obtained with Cu surfaces, with a ca. 20-fold reduction of SARS-Cov-2 and a 50-fold reduction in avian influenza. On the polymer brush-modified surfaces, the number of viable virus particles decreased by about 5−6 times faster for avian flu and about 2−3 times faster for SARS-CoV-2, all compared to unmodified silicon surfaces. Interestingly, no significant differences were obtained between quaternary ammonium brushes and zwitterionic brushes.

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“…So far, most superwetting surfaces only focus on a single function such as self-cleaning, [21] fog collection, [22] anticorrosion, [23] droplets transport, [24] antifouling, [25] and oil/ water separation. [26] However, with the development of human society, there is a growing need for multifunctional surfaces with synergistic effects in industrial and agricultural production.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Radiated Patterned Surface for Fog Collection, Oil/Water Separation, and Interfacial Floatability

Song

Zhang

Cheng

et al. 2022

Adv Materials Inter

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Multifunctional patterned surfaces with special wettability appeal to many researchers because of their potential applications in fog collection, microfluidics, and medical devices. To realize these functions and extend the corresponding application scopes, this article reports a multifunctional superhydrophobic radiated pattern on different wetting surfaces. Intriguingly, the hydrophilic surface with radiated pattern can quickly drive tiny water droplets toward more wetting regions, where water droplets move from center to the edge of a circle with a fog collection rate of about 3.075 g cm−2 h. However, the superhydrophobic surface with the radiated pattern triggers water to move from the edge to the center of a circle and achieves reverse transport. Importantly, the superhydrophobic surface can absorb oil and act as a micro‐reactor to realize oil/water separation. The surface can be transformed to be superhydrophilic by oxygen plasma etching and then recovers the superhydrophobicity by laser etching, which convinces the excellent restoration capacity. Furthermore, the surface composed of a superhydrophobic upper surface and a hydrophobic lower surface shows improved interfacial floatability. The findings offer a novel insight into the design of a multifunctional surface that not only enhances the fog collection but also realizes reverse liquid transport, and oil/water separation.

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Thermoresponsive, Pyrrolidone‐Based Antifouling Polymer Brushes

Cited by 18 publications

References 81 publications

Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications

Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications

Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating

A Multifunctional Radiated Patterned Surface for Fog Collection, Oil/Water Separation, and Interfacial Floatability

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