Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment

Peng, Chengjun; Wang, Guichun; Wang, Yuxiao; Tang, Maomao; Ma, Xiaodong; Chang, Xiangwei; Guo, Jian; Gui, Shuangying

doi:10.1002/pat.5874

Cited by 10 publications

(3 citation statements)

References 49 publications

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“…Peng et al employed N-acetylation to create an acetylated carboxymethyl CS for inclusion into an intelligent hydrogel for periodontal therapy. His research revealed that by varying the level of acetylation of the carboxymethyl CS hydrogels, the gelation temperature could be adjusted ( Peng et al, 2023 ). The gel formation temperature was 36.9°C when the extent of acetylation was 63.9%, and 33.2°C when the percentage of acetylation was 85.3%.…”

Section: Biomaterials Used To Construct Injectable Thermosensitive Hy...mentioning

confidence: 99%

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

El-Nablaway,

Rashed,

Taher

et al. 2024

Front. Bioeng. Biotechnol.

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Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies and logical therapy procedures provides the foundation for effective periodontitis treatment. Being biocompatible, biodegradable, and easily administered to the periodontal tissues, hydrogels have sparked substantial an intense curiosity in the discipline of periodontal therapy. The primary objective of hydrogel research has changed in recent years to intelligent thermosensitive hydrogels, that involve local adjustable sol-gel transformations and regulate medication release in reaction to temperature, we present a thorough introduction to the creation and efficient construction of new intelligent thermosensitive hydrogels for periodontal regeneration. We also address cutting-edge smart hydrogel treatment options based on periodontitis pathophysiology. Furthermore, the problems and prospective study objectives are reviewed, with a focus on establishing effective hydrogel delivery methods and prospective clinical applications.

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Section: Biomaterials Used To Construct Injectable Thermosensitive Hy...mentioning

confidence: 99%

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

El-Nablaway,

Rashed,

Taher

et al. 2024

Front. Bioeng. Biotechnol.

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“…Caffeic acid phenethyl ester (CAPE) is a polyphenolic natural substance with anti-inflammatory, antioxidant and bone defect repair effects. Pen et al [ 100 ] synthesized a thermosensitive hydrogel matrix of acetylated carboxymethyl chitosan (A-CS) and applied it for the first time for topical periodontal administration. Compared with conventional systemic drug delivery, the CAPE-loaded A-CS hydrogel (CAPE-A-CS) has the superiority of in situ drug reservoir formation, slow release and precise enhancement of drug concentration at the lesion site.…”

Section: Biomaterials Regulate Macrophage Polarizationmentioning

confidence: 99%

A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy

Peng,

Fu,

et al. 2024

J Nanobiotechnol

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Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials are being utilized more frequently in periodontal therapy due to their designability and unique drug delivery system. However, local and systemic immune response reactions driven by the implantation of biomaterials could result in inflammation, tissue damage, and fibrosis, which could end up with the failure of the implantation. Therefore, immunological adjustment of biomaterials through precise design can reduce the host reaction while eliminating the periodontal tissue's long-term chronic inflammation response. It is important to note that macrophages are an active immune system component that can participate in the progression of periodontal disease through intricate polarization mechanisms. And modulating macrophage polarization by designing biomaterials has emerged as a new periodontal therapy technique. In this review, we discuss the role of macrophages in periodontitis and typical strategies for polarizing macrophages with biomaterials. Subsequently, we discuss the challenges and potential opportunities of using biomaterials to manipulate periodontal macrophages to facilitate periodontal regeneration. Graphical Abstract

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“…Injectable chitosan-based hydrogels have had promising applications in the field of drug delivery because they become gelling matrices at the injection site, and they can release drugs in a controlled manner [ 44 , 172 , 173 , 175 ]. The hydrogel is used to treat periodontitis by forming a depot, allowing for a sustained release of caffeic acid phenethyl ester in the lesion sites [ 173 ]. The thermosensitive hydrogel matrix, made of acetylated CMC, effectively inhibits inflammation and promotes bone tissue repair in periodontitis therapy.…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment

Cited by 10 publications

References 49 publications

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

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