Thermosensitive Depot-Forming Injectable Phosphatidylcholine Blends Tailored for Localized Drug Delivery

Studies on the biological character of a new pH-sensitive doxorubicin prodrug with tumor targeting using a LC-MS/MS method

“…In recent years, anti-cancer drugs were usually conjugated to the macromolecular carrier via a cleavable hydrazine, amide or ester bond. 4 The polymer precursors include PEG, 5,6 PHEMA, [7][8][9] PAM, 10 and gelatin, 11 or block copolymers such as PEG-PLA, 12,13 or PEO-b-PAGE. 14 An amino acid 15 or oligo-peptide spacer 16,17 was oen incorporated in between the drug and the carrier polymer chain to adjust the release rate of the parent drug, and enhanced anti-tumor activity and therapeutic index were observed.…”