Thermosensitive graft copolymers of an amphiphilic macromonomer and N-vinylcaprolactam: synthesis and solution properties in dilute aqueous solutions below and above the LCST

Laukkanen, Antti; Valtola, Lauri; Winnik, Françoise M.; Tenhu, Heikki

doi:10.1016/j.polymer.2005.05.100

Cited by 36 publications

(29 citation statements)

References 41 publications

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“…The onset temperatures determined from the endotherms in Figure 8 were the same for all samples. A similar observation has been made by Laukkanen et al 42 with graft copolymers of PVCL and PEO in which the grafting density was varied. This had no effect to the T onset .…”

Section: Articlesupporting

confidence: 80%

Mesoporous silica particles grafted with poly(ethyleneoxide‐block‐N‐vinylcaprolactam)

Karesoja

McKee

Karjalainen

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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Mesoporous silica particles were grafted with thermoresponsive poly (ethyleneoxide-b-N-vinylcaprolactam), PEO-b-PVCL. N-vinylcaprolactam was first polymerized on particle surfaces using surface initiated atom transfer radical polymerization (SI-ATRP) and then, the poly(ethyleneoxide) blocks were attached to the PVCL chain ends with click chemistry. The sizes, thermoresponsiviness, and colloidal stability of SiO 2 -PVCL and SiO 2 -PVCL-b-PEO particles and their aqueous dispersions were studied by scanning electron microscopy, turbidimetry, dynamic light scattering, zeta sizer, and microcalorimetry. The phase separation temperature of the PEO-b-PVCL grafted particles did not considerably differ from that of the SiO 2 -PVCL particles. The zeta potential of the grafted particles was close to zero at room temperature but decreased strongly upon heating. The decrease is related to the collapse of the PVCL blocks and correspondingly, the exposure of the silica surface toward the aqueous phase. The colloidal stability of the particles could be enhanced by adding PEO blocks to the chain ends of the PVCL grafts.

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Section: Articlesupporting

confidence: 80%

Mesoporous silica particles grafted with poly(ethyleneoxide‐block‐N‐vinylcaprolactam)

Karesoja

McKee

Karjalainen

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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“…This tendency was also observed for PPZ A 14 -P 16 , which had the highest level of ABA and C 18 (EO) 10 while exhibiting the lowest DH LCST at pH 5. Indeed, a similar dependence was observed by Laukkanen et al (2005) for a thermosensitive polymer modified by increasing proportions of an amphiphilic graft.…”

Section: Physical Characterizationsupporting

confidence: 76%

Amphiphilic Ionizable Polyphosphazenes for the Preparation of pH‐Responsive Liposomes

Ghattas

Leroux

2008

Polyphosphazenes for Biomedical Applications

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“…Indeed, PVOH is known to aggregate and to adopt different conformations in water depending on the molecular weight, the degree of hydrolysis (residual acetate percentage), the temperature and the concentration 22, 42, 43. In addition, hydrogen bonds between PVOH and P N VCL are undoubtedly present since hydroxyl‐containing molecules are used for the physical cross‐linking of P N VCL 24, 44. Altogether, the specific interactions in the H 2 O/P N VCL/PVOH ternary system are expected to play a significant role in regulating the dehydration of P N VCL upon heating and in controlling the association mechanism and the size of the temperature‐induced aggregates.…”

Section: Resultsmentioning

confidence: 99%

Characteristics of patients who refuse do‐not‐resuscitate orders upon admission to an acute palliative care unit in a comprehensive cancer center

Parsons

Cruz

Zhukovsky

et al. 2010

Cancer

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BACKGROUND: Refusal of appropriately indicated do-not-resuscitate (DNR) orders may cause harm and distress for patients, families, and the medical team. We conducted a retrospective study to determine the frequency and predictors of refusals of DNR in advanced cancer patients admitted to an acute palliative care unit. METHODS: A total of 2538 consecutive admissions were reviewed. Demographic and clinical characteristics from 200 consecutive patients with DNR orders and 100 consecutive patients who refused DNR were collected, and differences between the groups were determined by multivariate regression and recursive partitioning analysis. RESULTS: Of 2538 admissions, 2530 (99%) were appropriate for DNR discussion. Of the 2530 admissions, 2374 were unique patients, and 100 (4%) of 2374 refused DNR. Refusers had median (interquartile range, IQR) pain of 7 (4-9) versus 5 (3-8, P ¼ .0005), nausea of 2 (0-7) versus 1 (0-4, P ¼ .05), and dyspnea of 1 (0-5) versus 4 (0-7, P ¼ .002) as compared with DNR nonrefusers, respectively. Patients with hematological malignancies and advance directives had a lower DNR refusal risk (odds ratio [OR], 0.38; P ¼ .02, and OR, 0.36; P < .0001, respectively). Multivariate regression analysis revealed that patients with moderate-severe pain (OR, 3.19; P ¼ .002) and with no advance directives (OR, 2.94; P .001) had higher DNR refusal risk. There were more inpatient deaths among DNR nonrefusers (87 of 200 vs 1 of 100, P < .0001). Median (IQR) time from discharge to death was 18 (8-35) days for those with DNR orders and 85 (25-206) days for DNR refusers (P .0001). CONCLUSIONS: DNR refusal in patients admitted to the acute palliative care unit is low, more frequent in patients with more pain and nausea and no advance directives, and associated with longer survival. This study demonstrates possible predictors of complicated DNR discussions. Cancer 2010;116:3061-70.

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Thermosensitive graft copolymers of an amphiphilic macromonomer and N-vinylcaprolactam: synthesis and solution properties in dilute aqueous solutions below and above the LCST

Cited by 36 publications

References 41 publications

Mesoporous silica particles grafted with poly(ethyleneoxide‐block‐N‐vinylcaprolactam)

Mesoporous silica particles grafted with poly(ethyleneoxide‐block‐N‐vinylcaprolactam)

Amphiphilic Ionizable Polyphosphazenes for the Preparation of pH‐Responsive Liposomes

Characteristics of patients who refuse do‐not‐resuscitate orders upon admission to an acute palliative care unit in a comprehensive cancer center

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