Thermosensitive hydrogel loaded with chitosan-carbon nanotubes for near infrared light triggered drug delivery

Dong, Xia; Wei, Chang; Liang, Jie; Liu, Tianjun; Kong, Deling; Lv, Feng

doi:10.1016/j.colsurfb.2017.03.036

Cited by 98 publications

(52 citation statements)

References 40 publications

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“…Incorporation of graphene oxide into chitosan improves the mechanical properties of chitosan in addition to enhancing its antimicrobial and pollutant removal abilities [88,89]. Chitosan being a biocompatible polymer has been applied to improve the solubility of CNT and reduce its toxicity to facilitate practical applications (Table 1) [90].…”

Section: Chitosan-carbon Materialsmentioning

confidence: 99%

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

et al. 2019

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Worldwide, millions of tons of crustaceans are produced every year and consumed as protein-rich seafood. However, the shells of the crustaceans and other non-edible parts constituting about half of the body mass are usually discarded as waste. These discarded crustacean shells are a prominent source of polysaccharide (chitin) and protein. Chitosan is a de-acetylated form of chitin obtained from the crustacean waste that has attracted attention for applications in food, biomedical, and paint industries due to its characteristic properties, like solubility in weak acids, film-forming ability, pH-sensitivity, biodegradability, and biocompatibility. We present an overview of the application of chitosan in composite coatings for applications in food, paint, and water treatment. In the context of food industries, the main focus is on fabrication and application of chitosan-based composite films and coatings for prolonging the post-harvest life of fruits and vegetables, whereas anti-corrosion and self-healing properties are the main properties considered for antifouling applications in paints in this review.

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Section: Chitosan-carbon Materialsmentioning

confidence: 99%

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

et al. 2019

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“…Near-infrared (NIR) light-induced drug delivery was achieved by embedding gold nanorods into thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) hydrogels which underwent shrinkage upon local heating of the nanorods due to NIR light irradiation, resulting in the triggered release of encapsulated drugs (Jiang et al, 2019). Carbon nanotubes were also used with the same goal by Dong et al (2017) that exploited their photothermal effect to trigger the release of doxorubicin from thermo-sensitive hydrogels based on a poly(ε-caprolactone)b-poly(ethylene glycol)-b-poly(ε-caprolactone) (PCL-PEG-PCL) triblock copolymer. However, differently from the former approach, triggered release was achieved in this case by exploiting a gel-to-sol transition occurring within the hydrogels in response to local heating induced by NIR light application.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Boffito

Torchio

Tonda‐Turo

et al. 2020

Front. Bioeng. Biotechnol.

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Hybrid Hydrogels for pH-Triggered Release in rodents. Moreover, MSN-CS-SIP-Ru-loaded gels turned out to be detectable through the skin by IVIS imaging. Cargo acid pH-triggered delivery from PEU-Boc and PEU-NH 2 gels was finally demonstrated through drug release tests in neutral and acid pH environments (in acid pH environment approximately 2-fold higher cargo release). Additionally, acid-triggered payload release from PEU-NH 2 gels was significantly higher compared to PEU-Boc systems at 3 and 4 days incubation. The herein designed hybrid injectable formulations could thus represent a significant step forward in the development of multi-stimuli sensitive drug carriers. Indeed, being able to adapt their behavior in response to biochemical cues from the surrounding physio-pathological environment, these formulations can effectively trigger the release of their payload according to therapeutic needs.

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“…There have been a lot of studies on the influence of properties of CTS and the concentration of polymers on the gelling of the thermo‐sensitive hydrogels (Azadi et al, 2018; Ganji et al, 2007), while few researchers pay attention to the solvent in thermo‐sensitive hydrogel. In fact, CTS can only be dissolved in a few types of acid, like formic acid, acetic acid, propinoic acid, butyric acid, hydrochloric acid, and so on (Dong et al, 2017). In the previous study of our team, CTS (deacetylation degree ≈ 90%, molecular weight ≈ 20–30 KD) and β‐GP were used as raw materials to prepare thermo‐sensitive gels, and the concentrations of the two materials for shortest gelling time were determined as 2% CTS + 7.8% β‐GP.…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, the practical application of thermo‐sensitive hydrogels is mainly restricted by three factors: the first is the biosafety of polymer materials, such as poly(lactic‐co‐glycolic acid)—polyethylene glycol (PEG) thermo‐sensitive gels and poly N‐isopropylacrylamide thermo‐sensitive gels (Dong et al, 2017; Wu et al, 2017; Wu, Shen, Banerjee, & Zhou, 2010; Xie et al, 2017); the second is unsatisfactory controlled drug release because of the long gelling time, large pore size, high water content, and poor mechanical strength of traditional thermo‐sensitive hydrogels (Assaad, Maire, & Lerouge, 2015; Li et al, 2017; Mahmoudian & Ganji, 2017); the third is the side effects of normal tissue caused by the spread of the gels over a large area (Zhao, Cheng, Ji, Kang, & Chen, 2009). Therefore, the development of safe and low‐cost thermo‐sensitive gels that can improve the drug‐controlled release is urgent for clinical application of mucosal drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release

et al. 2020

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Local drug injection therapy for tumor site, as a neoadjuvant chemotherapy method, shows important significance in clinical application; however, it obtains unsatisfying therapeutic effect due to the serious toxic and side effect in normal tissues caused by drug diffusion or complexity of the preparation. In this article, the influence factors of the gelling time of traditional Chitosan (CTS) thermo-sensitive hydrogels were analyzed, and the gelling properties were improved significantly, and a thermosensitive hydrogel with precisely regulated gelling time was obtained through a green and simple preparation method, and the shortest gelling time (gelling time = 27 ± 2 s) of this hydrogel was 5% of that of the common CTS thermo-sensitive hydrogels. After loaded with different chemotherapy drugs with different pH values (gemctiabin hydrochloride, levofloxacin, and 5-foluorouracil), the hydrogels' gelling performance was not affected, while the gelling time could be shortened by 5-foluorouracil, effectively hindering the drug loss at the early stage of sustained release. in vitro and in vivo experiments proved that precise encapsulation toward tumors with different volumes was achieved by the hydrogels, with minimal damage to surrounding normal tissues and higher utilization of drugs in tumor sites, ultimately achieving better tumor therapeutic effect. In conclusion, the new thermo-sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy. K E Y W O R D S drug-controlled release, gelling time, neoadjuvant chemotherapy, therapy in situ, thermosensitive hydrogels 1 | INTRODUCTION Thermo-sensitive hydrogels could achieve transformation between liquid and hydrogels according to the actual environmental temperature and act as a drug reservoir in injection site, with the advantages of controlled release, targeted drug delivery, and low toxicity (Culver,

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Thermosensitive hydrogel loaded with chitosan-carbon nanotubes for near infrared light triggered drug delivery

Cited by 98 publications

References 40 publications

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release

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