2011
DOI: 10.1002/jps.22309
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Thermosensitive Hydrogels Composed of Hyaluronic Acid and Gelatin as Carriers for the Intravesical Administration of Cisplatin

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Cited by 62 publications
(29 citation statements)
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“…This could be due to hydrophilic nature of the hydrogel with extensive presence of hydrogen bonded interpenetrating network. 42 Before checking the anti-cancer activity of the drug-loaded composite, in vitro release kinetics was pursued using UV-vis spectroscopy. The time-dependent cumulative release profiles are shown in Figure 8, which revealed that 75% of cisplatin was released at pH 4.5 within 24 h, whereas 52% was released at pH 7.4 in the same time.…”
Section: Resultsmentioning
confidence: 99%
“…This could be due to hydrophilic nature of the hydrogel with extensive presence of hydrogen bonded interpenetrating network. 42 Before checking the anti-cancer activity of the drug-loaded composite, in vitro release kinetics was pursued using UV-vis spectroscopy. The time-dependent cumulative release profiles are shown in Figure 8, which revealed that 75% of cisplatin was released at pH 4.5 within 24 h, whereas 52% was released at pH 7.4 in the same time.…”
Section: Resultsmentioning
confidence: 99%
“…[8][9][10][11][12] Recently, those gels have also been proven to be useful in cell encapsulation for bone and cartilage tissue engineering. [13][14][15][16][17][18] However, with major limitations such as nonbiodegradability and relatively low biocompatibility, 19 PNIPAM have been modified with many natural polymers, including chitosan, collagen, hyaluronic acid, or arginine-glycine-aspartate (RGD) peptide, to increase cell attachment, strengthen mechanical properties, and improve cell proliferation.…”
Section: Introductionmentioning
confidence: 99%
“…In a similar study, Pluronic F127 polymer formed a thermosensitive hydrogel for intravesical administration of liposomes and monomethoxy poly (ethylene glycol)-poly(ε-caprolactone) hybrid nanoparticles 46 . In another study, hydrogel was formed by co-polymerization of poly (N-isopropylacrylamide) with hyaluronic acid and gelatin 47 . Hydrogel formed by an 8% aqueous dispersion of co-polymer extended the dwell time of cisplatin in bladder.…”
Section: Major Challenges To Intravesical Therapymentioning
confidence: 99%