2022
DOI: 10.3390/gels8110723
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Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery

Abstract: The intra-articular administration of conventional drug solutions or dispersions in joint diseases such as osteoarthritis has a relatively short retention time and, therefore, limited therapeutic effect. Thermosensitive polymer solutions that exhibit a sol–gel phase transition near body temperature after injection can prolong drug retention by providing a depot from which the drug release is sustained while relieving inflammation and preventing degradation of the joint complex. Thermosensitive hydrogels have i… Show more

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Cited by 16 publications
(2 citation statements)
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“…[194,195] Thermal-responsive nanomaterials leverage the slight variations in temperature associated with pathological conditions to transition from liquid to gel states, forming a localized depot for sustained drug release. [196,197] Similarly, protease-responsive nanomaterials are also developed to release their therapeutic payloads in response to the activity of specific enzymes, such as metalloproteinases, which are upregulated in OA-affected joint. [198,199] These smart response mechanisms ensure that the drug release is not only precisely targeted but also temporally controlled, aligning drug availability with the pathological state of the joint.…”
Section: Drug Deliverymentioning
confidence: 99%
“…[194,195] Thermal-responsive nanomaterials leverage the slight variations in temperature associated with pathological conditions to transition from liquid to gel states, forming a localized depot for sustained drug release. [196,197] Similarly, protease-responsive nanomaterials are also developed to release their therapeutic payloads in response to the activity of specific enzymes, such as metalloproteinases, which are upregulated in OA-affected joint. [198,199] These smart response mechanisms ensure that the drug release is not only precisely targeted but also temporally controlled, aligning drug availability with the pathological state of the joint.…”
Section: Drug Deliverymentioning
confidence: 99%
“…Thermogels undergo sol-gel transition under certain temperature conditions and the temperature of the gel shows the temperature of the phenomenon. Therefore, the basic requirement to create a viscous preparation is to determine the solgel transition temperature [27]. Chitosan is a hydrolyzed polysaccharide derivative of chitin and a widespread biopolymer in nature, which is non-toxic, biocompatible and biodegradable [28].…”
Section: Introductionmentioning
confidence: 99%