Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform

Kim, Jang Il; Chun, ChangJu; Kim, Bora; Hong, Jae‐Hee; Cho, Jung-Kyo; Lee, Jun Young; Song, Soo‐Chang

doi:10.1016/j.biomaterials.2011.09.033

Cited by 97 publications

(59 citation statements)

References 34 publications

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“…[51][52][53] By using this method, NC gels with uniform magnetic nanoparticle size can be obtained. However, (Fig.…”

Section: Nanocomposite Hydrogelmentioning

confidence: 99%

“…6). 53 The NC gel showed excellent thermosensitivity, reversible sol-gel phase transition, and injectability; the gel was injected into a rat brain using stereotactic surgery for long-term magnetic resonance imaging. In the in situ precipitation process, the magnetic nanoparticles are formed via chemical reaction of the precursor salts inside the hydrogel matrix.…”

Section: Nanocomposite Hydrogelmentioning

confidence: 99%

See 1 more Smart Citation

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

226

103

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Traditional hydrogels usually possess inferior mechanical properties as well as lacking multi-functionalities. Nano-sized particles/fillers, both inorganic and organic materials, have unique chemical, physical, and biological functions, and have been extensively studied as biomaterials or bio-functional materials. Nanocomposite hydrogels, which combine the advantages of both nano-fillers and hydrogel matrices, may result in improved mechanical and biological properties and find their potential applications in biomedical field. This paper reviews recent developments in the synthesis, preparation, and characterization of nanocomposite hydrogels; their biomedical applications, such as drug delivery matrices and tissue engineering scaffolding materials are also summarized.

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“…[51][52][53] By using this method, NC gels with uniform magnetic nanoparticle size can be obtained. However, (Fig.…”

Section: Nanocomposite Hydrogelmentioning

confidence: 99%

Section: Nanocomposite Hydrogelmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

226

103

View full text Add to dashboard Cite

show abstract

“…12,[288][289][290][291][292][293][294] In addition, carboxylic acid on PPP has been used as a conjugation site for anticancer drugs such as paclitaxel, doxorubicin, and camptothecin. 291,292,295 The anticancer drug release behaviors of the conjugated in situ-forming PEG-PPP hydrogels relies on the physicochemical properties, hydrolytic degradation, and the composition of the substitution groups on PPP.…”

Section: Peg and Polyphosphazenes (Ppps)mentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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“…For instance, gene/drug-NPloaded micro¯bers and MNPs-loaded thermosensitive hydrogels implanted in tumor beds have been demonstrated to achieve a sustained release of each agent, resulting in e®ective therapy and diagnosis. 150,151 Nevertheless, the complex anticancer agent di®usion is less than a few millimeters from the injection/implantation site. What is more, the di®usion technologies is hard to standardize and control.…”

Section: Nanomaterials In Local Administrationmentioning

confidence: 99%

The Application of Nanomaterials in Diagnosis and Treatment for Malignant Primary Brain Tumors

Liang

Fang

2014

NANO

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Malignant primary brain tumors have a very high morbidity and mortality. Even though enormous advances have been made in primary brain tumor management, in the case of malignant primary brain tumors, current diagnostic strategies cannot identify exact in¯ltrating margins, surgery alone cannot achieve total mass resection, and adjuvant therapies cannot improve survivals. Therefore, there is an urgent need to explore novel strategies to diagnose and treat such in¯ltrating brain tumors. Nanomaterials, particularly zero-dimensional and one-dimensional platforms, can carry various compounds such as contrast agents, anticancer drugs and genes into brain tumor cells speci¯cally. Thus, contrast agent-based nanomaterials can selectively present in¯ltrating tumor outlines, while anticancer agent-based nanomaterials can speci¯cally kill malignant tumor cells. In addition, dual-targeting nanomaterials, multifunctional nanocarriers, theranostic nanovehicles as well as convection-enhanced delivery technology hold promise to increase drug accumulation in tumor tissues, which could largely improve anticancer e±cacy. In this review, we will mainly focus on the application of nanomaterials in preoperative diagnosis, intraoperative diagnosis and adjuvant treatment for malignant primary brain tumors.

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Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform

Cited by 97 publications

References 34 publications

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

The Application of Nanomaterials in Diagnosis and Treatment for Malignant Primary Brain Tumors

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