Thermosensitive Micelle-Forming Block Copolymers of Poly(ethylene glycol) and Poly(<i>N</i>-isopropylacrylamide)

Topp, M.D.C.; Dijkstra, Pieter J.; Talsma, H.; Feijén, Jan

doi:10.1021/ma9710803

Cited by 321 publications

(290 citation statements)

References 14 publications

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“…DHBCs can spontaneously form well-defined micelle aggregates in a selective solvent and water [14][15][16][17]. According to previous works, many factors may affect the final morphologies of the aggregates.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

et al. 2009

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Poly(ethylene oxide)-b-poly(2-hydroxyethyl methacrylate) (PEO-b-PHEMA) was synthesized by successive atom transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate（HEMA） monomer using PEO-Br macroinitiator as initiator, CuBr/CuBr 2 and 2,2"-bipyridyl (bpy) as catalyst and ligand. IR, 1 H NMR, and GPC analysis indicate that PEO-b-PHEMA block copolymer with low polydispersity index (M w /M n ≈ 1.1) has been formed. Selfassembly of this double hydrophilic block copolymer in the selective solvent and water was also studied. Owing to the high hydrophilic nature of the PEO and PHEMA blocks, this double hydrophilic block copolymer cannot disperse well in water. So block copolymer was modified by part esterification of PEO-b-PHEMA with acetic anhydride, which increased the hydrophobic group of the PHEMA block. The TEM results show that this block copolymer spontaneously form well-defined micelles in water.

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Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

et al. 2009

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“…During the past decade, block copolymers of PEO and poly(N-isopropylacrylamide) (PNIPAAm) have been synthesized and studied [3,8,9]. PNIPAAm, one of the most studied thermosensitive polymers, has a lower critical solution temperature (LCST) of about 32°C in aqueous solution [10,11].…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene oxide)-b-poly(N-isopropylacrylamide) nanoparticles with cross-linked cores as drug carriers

Zeng¹,

Pitt²

2005

Journal of Biomaterials Science, Polymer Edition

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Micelle-like nanoparticles that could be used as drug delivery carriers were developed. The unique feature of these nanoparticles was that the core of poly(ethylene oxide)-b-poly(Nisopropylacrylamide) (PEO-b-PNIPAAm) micelle was lightly crosslinked with a biodegradable crosslinker N,N-bis(acryloyl)cystamine (BAC). The nanoparticles were characterized by dynamic light scattering and fluorescence measurements. When the BAC was from 0.75 wt% to 0.2 wt% of the mass of NIPAAm, the diameters of the nanoparticles were less than 150 nm. The anti-cancer drug doxorubicin (Dox) and 1,6-diphenyl-1,3,5-hexatriene (DPH) were used as fluorescent probes to study the hydrophobicity of the cores of the nanoparticles; the results showed that the cores of the nanoparticles were hydrophobic enough to sequester Dox and DPH. The nanoparticles with 0.5 wt % BAC stored at room temperature were stable up to two weeks, even at dilute concentrations. The degradation of BAC by reducing agent β-mercaptoethanol was investigated, and the nanoparticles were not detectable 14 days after adding β-mercaptoethanol.

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“…When combined with a hydrophilic block, the copolymers are soluble at a temperature below the LCST and no association is observed. At a temperature above the LCST, the thermo-sensitive blocks turn hydrophobic and micellization takes place [17][18].…”

Section: Introductionmentioning

confidence: 99%

Association behavior of thermo-responsive block copolymers based on poly(vinyl ethers)

Verdonck

Khousakoun²,

Jérôme³

et al. 2005

Polymer

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Thermo-sensitive nanosized structures have been prepared in water from poly(methyl vinyl ether)-blockpoly(isobutyl vinyl ether) (PMVE-b-PIBVE) block copolymers. The composition and the architecture (diblock and triblock architectures) of the PMVE-b-PIBVE copolymers have been varied. The investigated copolymers had an asymmetric composition with a major PMVE block. While the PIBVE blocks are hydrophobic, the PMVE blocks are hydrophilic at room temperature and become hydrophobic above their demixing temperature (around 36 °C) as a result of the lower critical solution temperature (LCST) behavior. At room temperature, the amphiphilic copolymers aggregate in water above a critical micelle concentration, which has been experimentally measured by hydrophobic dye solubilization. The hydrodynamic diameter of the structures formed above the cmc has been measured by dynamic light scattering (DLS) while their morphology has been studied by transmission electron microscopy (TEM). 1 H NMR measurements in D 2 O at room temperature reveal that the aggregates contain PIBVE insoluble regions surrounded by solvated PMVE chains. These investigations have shown that polydisperse spherical micelles are formed for asymmetric PMVE-b-PIBVE copolymers containing at least 9 IBVE units. For copolymers containing less IBVE units, loose aggregates are formed.Finally, the thermo-responsive, reversible properties of these structures have been investigated. Above the cloud point of the copolymers, the loose aggregates precipitate while the micelles form large spherical structures.

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Thermosensitive Micelle-Forming Block Copolymers of Poly(ethylene glycol) and Poly(N-isopropylacrylamide)

Cited by 321 publications

References 14 publications

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

Synthesis and self-assembly of poly(ethylene oxide)-b-poly (2-hydroxyethyl methacrylate)

Poly(ethylene oxide)-b-poly(N-isopropylacrylamide) nanoparticles with cross-linked cores as drug carriers

Association behavior of thermo-responsive block copolymers based on poly(vinyl ethers)

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