Thermosensitive nanosized micelles from cholesteryl-modified hydroxypropyl cellulose as a novel carrier of hydrophobic drugs

Bagheri, Massoumeh; Shateri, Shaghayegh

doi:10.1007/s13726-012-0037-y

Cited by 20 publications

(14 citation statements)

References 25 publications

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“…We previously reported on selfassembling CHD nanoparticles having a core-shell structure [11,25]. Self-assembled CHD nanoparticles are composed of cholesterol-conjugated HPC backbone.…”

Section: Self-assembly and Micellar Properties Of Biotinylated Modifimentioning

confidence: 99%

“…This phase transition, which is referred to as the lower critical solution temperature (LCST) in aqueous solution, is particularly attractive for applications in drug delivery, smart bioactive surfaces, and molecular recognition agents [8,9]. Among the natural and thermosensitive polymers, hydroxypropyl cellulose (HPC) is attractive due to its wide and tunable LCST, which is in the range of 41-45 ºC in water [10,11] and can be adjusted by grafting HPC with a more hydrophobic side chain. Due to its excellent biological and physicochemical features, namely biodegradability [12], non-toxicity and polyfunctionality, together with thermoresponsivity, this polymer has become an attractive ingredient for many pharmaceutical applications and chemical manipulations [13].…”

Section: Introductionmentioning

confidence: 99%

“…We have previously reported the potential of selfassembling micellar nanoparticles using amphiphilic cholesteryl-modified HPC derivatives (HPC-Chol) with different modification ratios [11,25]. Introduction of cholesterol as a hydrophobic group can enhance the association behavior of HPC-Chol, and the stable activity of the hydrophobic drug can be enhanced by forming a hydrophobic core.…”

Section: Introductionmentioning

confidence: 99%

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Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

et al. 2014

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In this article, we report the synthesis of a novel amphiphilic hydroxypropyl cellulose-based polymer (HPC-PEG-Chol) that contained poly (ethylene glycol) and cholesterol-containing moieties with specific degrees of substitution. The resulting polymer was subsequently converted to a biotin conjugate (HPC-PEG-Chol-biotin), to develop a new potential cancer-targeted drug delivery system. The biotin conjugate was used to prepare micelles via the dialysis method. The polymeric micelles in aqueous solution presented a lower critical solution temperature (LCST) of 39.8 o C. The critical micelle concentration (CMC) values of the polymeric micelles at 25 and 45°C were evaluated to be about 0.32 and 0. 25 g/L, respectively. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses of the micelles revealed the spherical shapes of the micelles, with 84 nm mean diameters that increased with the increase of the temperature above LCST. The hydrophobic anticancer drug paclitaxel (PTX) was loaded in the micelles and the in vitro release behaviors of PTX were investigated at different temperatures. The release profile of PTX from the polymeric micelles revealed a thermosensitivity, since its release rate was higher at 41°C than at 37°C. Fluorescent microscopy analyses confirm that the PTX-loaded HPC-PEG-Cholbiotin is superior in cellular uptake, with very strong adsorption to both HeLa and MDA-MB-231 cancer cell lines. MTT assay in normal cells indicated that HPC-PEG-Chol-biotin micelles have great potential to be safely used in tumortargeting chemotherapy.

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“…We previously reported on selfassembling CHD nanoparticles having a core-shell structure [11,25]. Self-assembled CHD nanoparticles are composed of cholesterol-conjugated HPC backbone.…”

Section: Self-assembly and Micellar Properties Of Biotinylated Modifimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

et al. 2014

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“…Cellulose supramolecular materials are the most promising materials in this field and have been widely studied, especially the self-assembly characteristics of cellulose graft copolymers (Kang et al 2006;Li et al 2008;Liu et al 2012;Shen et al 2006;Vshivkov and Galyas 2011;Yang et al 2008;Yokota et al 2008;Zhao et al 2010). The responsiveness to the external environment Wan et al 2007;Yuan et al 2012) such as temperature (Phan et al 2011) and pH (Dou and Jiang 2007;Wang et al 2011), have led to applications across materials science (smart or adaptive materials, information-recording materials) and medicine (drug release carriers) (Bagheri and Shateri 2012;Dou and Jiang 2007;Tan et al 2010;Wang et al 2011). There are few reports on the use of cyclodextrin as a driving force for the environmental response of lignocellulose-based supramolecular assemblies.…”

Section: Introductionmentioning

confidence: 99%

The Study of Intermolecular Inclusion in Cellulose Physical Gels

Duan¹,

Jiang²,

Han³

et al. 2014

BioResources

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In this study, cellulose possessing β-cyclodextrin (β-CD) is employed as a host molecule, and cellulose possessing ferrocene (Fc) is used as a guest polymer. The properties due to the host-guest interactions are presented. The results show that β-CD-cellulose and Fc-cellulose can form inclusion complexes wherein hydrophobic interaction caused by β-CD-cellulose and Fc-cellulose significantly affect the performance of the cellulose gel. A physical gel based on cellulose that can autonomously heal between cut surfaces after 24 h was formed under mild conditions. Moreover, ferrocene redox status affects the hydrophobic interaction, such that the hydrophobic interaction can strengthen the gel strength and affect the self-healing property.

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“…Cellulose, the most abundant and renewable polysaccharide on earth, has been wildly used in the chemical and biological industries for its safe, biocompatible, hydrophilic and biodegradable natures [16][17][18]. It is noted that cellulose also has a neutral inherent taste as well as a regulatory effect on digestion.…”

Section: Introductionmentioning

confidence: 99%

An investigation of flavor encapsulation comprising of regenerated cellulose as core and carboxymethyl cellulose as wall

Tan

Dai

et al. 2013

Iran Polym J

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The potential application of flavor encapsulation comprising regenerated porous cellulose particles (RPC) as core and carboxymethyl cellulose (CMC) as wall was investigated using L-menthol as a model flavor. RPC was prepared by sol-gel transition method and characterized by Fourier-transform infrared (FTIR) spectra, scanning electron microscopy (SEM) and micromeritics instruments. The results revealed that the RPC showed the particle size about 300-500 lm as well as the specific surface area about 8.7 m 2 /g. Based on high adsorptive capability, RPC could encapsulate menthol well and offer high encapsulation yield. The menthol content of RPC-menthol complexes (RPCM) was measured by gas chromatogram (GC) and showed the maximum content of about 12 % menthol with the encapsulation efficiency of 70 %. Besides, RPC provided comparable flavor retention as microcrystalline cellulose during storage under relative humidity of 80 % at 25°C. CMC was then used to modify RPCM and the construction of RPCM-CMC was confirmed by FTIR and SEM. The studies showed that CMC wall on RPCM surface had no influence on the menthol content and encapsulation efficiency in encapsulation process, but provided a significant increase in menthol retention during storage depending on the content of CMC in RPCM-CMC. Moreover, the stability test at various temperatures showed that both RPCM and RPCM-CMC were stable at room temperature and released flavor at temperatures common in food processing. It was concluded that RPC and CMC modification shows great potential as flavor encapsulant.

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Thermosensitive nanosized micelles from cholesteryl-modified hydroxypropyl cellulose as a novel carrier of hydrophobic drugs

Cited by 20 publications

References 25 publications

Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

The Study of Intermolecular Inclusion in Cellulose Physical Gels

An investigation of flavor encapsulation comprising of regenerated cellulose as core and carboxymethyl cellulose as wall

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