2021
DOI: 10.1098/rstb.2020.0101
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Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles,Apalone spinifera

Abstract: Sex chromosome dosage compensation (SCDC) overcomes gene-dose imbalances that disturb transcriptional networks, as when ZW females or XY males are hemizygous for Z/X genes. Mounting data from non-model organisms reveal diverse SCDC mechanisms, yet their evolution remains obscure, because most informative lineages with variable sex chromosomes are unstudied. Here, we discovered SCDC in turtles and an unprecedented thermosensitive SCDC in eukaryotes. We contrasted RNA-seq expression of Z-genes, their autosomal o… Show more

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Cited by 26 publications
(29 citation statements)
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“…If these sex‐specific regulatory pathways are costly or are likely to break down with age, they might contribute to sex differences in aging. The recent report of environmentally sensitive dosage compensation in turtles with ZZ/ZW sex chromosomes, which is also age‐ and tissue‐dependent (Bista et al 2021 ), adds to the complexity of factors potentially affecting sex‐specific aging. Selecting species with similar genomic features that differ in sex chromosome regulation might provide insights into how these pathways impact genome instability and/or sex differences in aging.…”
Section: Opportunities For Research Into Sex Differences In Agingmentioning
confidence: 99%
“…If these sex‐specific regulatory pathways are costly or are likely to break down with age, they might contribute to sex differences in aging. The recent report of environmentally sensitive dosage compensation in turtles with ZZ/ZW sex chromosomes, which is also age‐ and tissue‐dependent (Bista et al 2021 ), adds to the complexity of factors potentially affecting sex‐specific aging. Selecting species with similar genomic features that differ in sex chromosome regulation might provide insights into how these pathways impact genome instability and/or sex differences in aging.…”
Section: Opportunities For Research Into Sex Differences In Agingmentioning
confidence: 99%
“…The third documented type of a gene dose regulatory mechanism is an incomplete compensation without balance, also referred to as incomplete or partial dosage compensation, where expression of sex-specific loci remains lower in the heterogametic sex relative to the homogametic sex [164]. Nevertheless, we should also keep in mind that the gene dose regulatory mechanisms can be tissue-and age-specific [165]. A complete (global) or nearly complete dosage compensation or at least dosage balance between sexes was often found in lineages with XX/XY sex determination.…”
Section: Is the Sex Chromosome Differentiationmentioning
confidence: 99%
“…Studies on the molecular basis of TSD often investigate the expression of gonadal genes throughout embryonic stages, particularly focusing on the TSP. Recent advents in sequencing techniques have revealed genes presumably involved in gonadal sex differentiation or sexually distinct transcription in TSD species [11][12][13][14][15][16] , which were further investigated in Alligator mississippiensis and T. scripta embryos using techniques, such as pharmacological treatments and genetic manipulations via viral infections, respectively 12,17,18 . These manipulations were used to evaluate whether the sex expected from a femaleor male-producing incubation temperature (FPT or MPT, respectively) could be reversed, assuming that gonadal sex was structurally undifferentiated at the time of these manipulations.…”
Section: Introductionmentioning
confidence: 99%