Thermovaccination – thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

Варфоломеев, С. Д.; Панин, А. Н.; Bykov, V. I.; Цыбенова, С. Б.; Журавель, С. В.; Ryabokon, Anna; Уткина, И. И.; Gavrilov, Pavel; Петриков, С. С.; Shogenova, L. V.; Chuchalin, Alexander

doi:10.1016/j.cbi.2020.109339

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…В последние десятилетия в комплексном лечении больных с респираторными патологиями хорошо себя зарекомендовала терапия медицинскими газами [12][13][14], в частности водородная терапияингаляция смесью кислорода и водорода. Имеются сообщения о влиянии АФВ на активность противовоспалительных медиаторов, сложилось предварительное впечатление о спаринг-эффекте водорода и при ингаляции кислородом [6].…”

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Changes in the proteomics of exhaled breath condensate under the influence of inhaled hydrogen in patients with post-COVID syndrome

Ryabokon

Zakharova

Indeykina

et al. 2023

Cardiovasc Ther Prev

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Aim. To study the effect of inhalation therapy with an active hydrogen (AH) on the protein composition of exhaled breath condensate (EBC) in patients with post-COVID syndrome (PCS).Material and methods. This randomized controlled parallel prospective study included 60 patients after coronavirus disease 2019 (COVID-19) with PCS during the recovery period and clinical manifestations of chronic fatigue syndrome who received standard therapy according to the protocol for managing patients with chronic fatigue syndrome (CFS). The patients were divided into 2 groups: group 1 (main) — 30 people who received standard therapy and AH inhalations (SUISONIA, Japan) for 10 days, and group 2 (control) — 30 medical workers who received only standard therapy. Patients in both groups were comparable in sex and mean age. All participants in the study were sampled with EBC on days 1 and 10. Samples were subjected to tryptic digestion and high-performance liquid chromatography combined with tandem mass spectrometry analysis using a nanoflow chromatograph (Dionex 3000) in tandem with a high-resolution time-of-flight mass spectrometer (timsTOF Pro).Results. A total of 478 proteins and 1350 peptides were identified using high resolution mass spectrometry. The number of proteins in samples after AH therapy, on average, is 12% more than before treatment. An analysis of the distribution of proteins in different groups of patients showed that only half of these proteins (112) are common for all groups of samples and are detected in EBC before, after, and regardless of hydrogen therapy. In addition to the qualitative difference in the EBC protein compositions in different groups, quantitative changes in the concentration of 36 proteins (mainly structural and protective) were also revealed, which together made it possible to reliably distinguish between subgroups before and after treatment. It is worth noting that among these proteins there are participants of blood coagulation (а-1-antitrypsin), chemokine- and cytokine-mediated inflammation, and a number of signaling pathways (cytoplasmic actin 2), response to oxidative stress (thioredoxin), glycolysis (glyceraldehyde-3- phosphate dehydrogenase), etc.Conclusion. The use of hydrogen therapy can contribute to the switching of a number of physiological processes, which may affect the success of recovery in PCS patients. In particular, the obtained results indicate the activation of aerobic synthesis of adenosine triphosphate in mitochondria by hydrogen therapy, which correlates well with the decrease in the blood lactate level detected by laboratory studies. At the same time, this therapy can inhibit pro-inflammatory activity, negatively affecting the coagulation and signaling pathways of integrins and apoptosis, and, in addition, activate protective pathways, tricarboxylic acid cycle, FAS signaling, and purine metabolism, which may be essential for effective recovery after COVID-19.

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Section: Discussionunclassified

Changes in the proteomics of exhaled breath condensate under the influence of inhaled hydrogen in patients with post-COVID syndrome

Ryabokon

Zakharova

Indeykina

et al. 2023

Cardiovasc Ther Prev

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Thermoheliox: effect on the functional hemodynamics of the human brain

Варфоломеев

Panin²,

Семенова

et al. 2022

Russ Chem Bull

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A kinetic study of the effect of thermoheliox (inhalation of a helium and oxygen mixture, 70 °C) on the functional hemodynamics of the human brain by functional magnetic resonance imaging was carried out. The dynamic responses of the BOLD signal were found to be biphasic. An empirical equation describing the first phase of the hemodynamic response to visual stimulus was proposed. It was shown that preliminary inhalation of thermoheliox stimulates the hemodynamic responses by slowing down the vasoconstriction.

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Molecular mechanism and regulation of neurovascular coupling in the human brain: The influence of thermoheliox

Варфоломеев

Panin²,

Семенова

et al. 2022

Chemical Physics Letters

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Thermovaccination – thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

Cited by 4 publications

References 8 publications

Changes in the proteomics of exhaled breath condensate under the influence of inhaled hydrogen in patients with post-COVID syndrome

Changes in the proteomics of exhaled breath condensate under the influence of inhaled hydrogen in patients with post-COVID syndrome

Thermoheliox: effect on the functional hemodynamics of the human brain

Molecular mechanism and regulation of neurovascular coupling in the human brain: The influence of thermoheliox

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